136 research outputs found
Evaluation of striped bass stocks in Virginia, monitoring and tagging studies, 2010-2014 Progress report, 1 September 2013 - 31 August 2014
This report presents the results of striped bass (Morone saxatilis) tagging and monitoring activities in Virginia during the period 1 September 2013 through 31 August 2014. It includes an assessment of the biological characteristics of striped bass taken from the 2014 spring spawning run, estimates of annual survival and fishing mortality based on annual spring tagging, and the results of the study that documents the prevalence of mycobacterial infections of striped bass in Chesapeake Bay. Also included is information on gear selectivity of recreational anglers for striped bass and on impacts of dermal mycobacteriosis on striped bass. The information contained in this report is required by the Atlantic States Marine Fisheries Commission and is used to implement a coordinated management plan for striped bass in Virginia, and along the eastern seaboard
Evaluation of striped bass stocks in Virginia, monitoring and tagging studies, 2010-2014 : Progress report, 1 September 2010 - 31 August 2011
This report presents the results of striped bass (Morone saxatilis) tagging and monitoring activities in Virginia during the period 1 September 2010 through 31 August 2011. It includes an assessment of the biological characteristics of striped bass taken from the 2011 spring spawning run, estimates of annual survival and fishing mortality based on annual spring tagging, and the results of the study that documents the prevalence of mycobacterial infections of striped bass in Chesapeake Bay. The information contained in this report is required by the Atlantic States Marine Fisheries Commission and is used to implement a coordinated management plan for striped bass in Virginia, and along the eastern seaboard
Evaluation of Striped Bass Stocks in Virginia: Monitoring and Tagging Studies, 2010-2014 Annual Report 1 September 2009 - 31 August 2010
This report presents the results of striped bass (Morone saxatilis) tagging and monitoring activities in Virginia during the period 1 September 2009 through 31 August 2010. It includes an assessment of the biological characteristics of striped bass taken from the 2010 spring spawning run, estimates of annual survival and fishing mortality based on annual spring tagging, and the results of the study that documents the prevalence of mycobacterial infections of striped bass in Chesapeake Bay. The information contained in this report is required by the Atlantic States Marine Fisheries Commission and is used to implement a coordinated management plan for striped bass in Virginia, and along the eastern seaboard
Evaluation of Striped Bass Stocks in Virginia: Monitoring and Tagging Studies, 2015-2019 Progress Report 1 September 2014 - 31 August 2015
This report presents the results of striped bass (Morone saxatilis) tagging and monitoring activities in Virginia during the period 1 September 2014 through 31 August 2015. It includes an assessment of the biological characteristics of striped bass taken from the 2015 spring spawning run and estimates of annual survival and fishing mortality based on annual spring tagging. Also included is information on gear selectivity of recreational anglers for striped bass. The information contained in this report is required by the Atlantic States Marine Fisheries Commission and is used to implement a coordinated management plan for striped bass in Virginia, and along the eastern seaboard
Evaluation of Striped Bass Stocks in Virginia: Monitoring and Tagging Studies, 2015-2019 : Progress Report 1 September 2015 - 31 August 2016
This report presents the results of striped bass (Morone saxatilis) tagging and monitoring activities in Virginia during the period 1 September 2015 through 31 August 2016. It includes an assessment of the biological characteristics of striped bass taken from the 2016 spring spawning run, estimates of annual survival and fishing mortality based on annual spring tagging, and the results of the study that documents the prevalence of mycobacterial infections of striped bass in Chesapeake Bay. Also included is an investigation on the potential use of close-kin analyses to determine the size of the spawning stock in the Rappahannock River. The information contained in this report is required by the Atlantic States Marine Fisheries Commission and is used to implement a coordinated management plan for striped bass in Virginia, and along the eastern seaboard
Evaluation of striped bass stocks in Virginia : monitoring and tagging studies, 2004-2008 - Annual Report 1 September 2006 - 31 August 2007
This report presents the results of striped bass (Morone saxatilis) tagging and monitoring activities in Virginia during the period 1 September 2006 through 31 August 2007. It includes an assessment of the biological characteristics of striped bass taken from the 2007 spring spawning run, estimates of annual survival and fishing mortality based on annual spring tagging, and the preliminary results of the fall 2006 study that documents the prevalence of mycobacterial infections of striped bass in Chesapeake Bay. The information contained in this report is required by the Atlantic States Marine Fisheries Commission and is used to implement a coordinated management plan for striped bass in Virginia, and along the eastern seaboard
Evaluation of striped bass stocks in Virginia, monitoring and tagging studies, 2005-2009 Annual report, 1 September 2008 - 31 August 2009
This report presents the results of striped bass (Morone saxatilis) tagging and monitoring activities in Virginia during the period 1 September 2008 through 31 August 2009. It includes an assessment of the biological characteristics of striped bass taken from the 2009 spring spawning run, estimates of annual survival and fishing mortality based on annual spring tagging, and the results of the study that documents the prevalence of mycobacterial infections of striped bass in Chesapeake Bay. The information contained in this report is required by the Atlantic States Marine Fisheries Commission and is used to implement a coordinated management plan for striped bass in Virginia, and along the eastern seaboard
Evaluation of striped bass stocks in Virginia, monitoring and tagging studies, 2004-2008 Annual report, 1 September 2007 - 31 September 2008
This report presents the results of striped bass (Morone saxatilis) tagging and monitoring activities in Virginia during the period 1 September 2007 through 31 August 2008. It includes an assessment of the biological characteristics of striped bass taken from the 2008 spring spawning run, estimates of annual survival and fishing mortality based on annual spring tagging, and the results of the study that documents the prevalence of mycobacterial infections of striped bass in Chesapeake Bay. The information contained in this report is required by the Atlantic States Marine Fisheries Commission and is used to implement a coordinated management plan for striped bass in Virginia, and along the eastern seaboar
Evaluation of Striped Bass Stocks in Virginia: Monitoring and Tagging Studies, 2015-2019 Progress Report 1 September 2016 - 31 November 2017
This report presents the results of striped bass (Morone saxatilis) tagging and monitoring activities in Virginia during the period 1 September 2016 through 31 August 2017. It includes an assessment of the biological characteristics of striped bass taken from the 2017 spring spawning run and estimates of annual survival and fishing mortality based on annual spring tagging. Also included is an investigation on the potential use of close-kin analyses to determine the size of the spawning stock in the Rappahannock River and an evaluation of mortality rates associated with the bacterial dermal disease mycobacteriosis in relation to water temperatures and dissolved oxygen. The information contained in this report is required by the Atlantic States Marine Fisheries Commission and is used to implement a coordinated management plan for striped bass in Virginia, and along the eastern seaboard
Oncolytic HSV Vectors and Anti-Tumor Immunity
The therapeutic promise of oncolytic viruses (OVs) rests on their ability to both selectively kill tumor cells and induce anti-tumor immunity. The potential of tumors to be recognized and eliminated by an effective anti-tumor immune response has been spurred on by the discovery that immune checkpoint inhibition can overcome tumor-specific cytotoxic T cell (CTL) exhaustion and provide durable responses in multiple tumor indications. OV-mediated tumor destruction is now recognized as a powerful means to assist in the development of anti-tumor immunity for two important reasons: (i) OVs, through the elicitation of an anti-viral response and the production of type I interferon, are potent stimulators of inflammation and can be armed with transgenes to further enhance anti-tumor immune responses; and (ii) lytic activity can promote the release of tumor-associated antigens (TAAs) and tumor neoantigens that function as in situ tumor-specific vaccines to elicit adaptive immunity. Oncolytic herpes simplex viruses (oHSVs) are among the most widely studied OVs for the treatment of solid malignancies, and Amgen's oHSV Imlygic® for the treatment of melanoma is the only OV approved in major markets. Here we describe important biological features of HSV that make it an attractive OV, clinical experience with HSV-based vectors, and strategies to increase applicability to cancer treatment
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