Boletín oficial de la provincia de León: Boletín oficial de la provincia de León: Número 244 - 1963 octubre 29 (29/10/1963)

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2011-201

Boletín oficial de la provincia de León: Boletín oficial de la provincia de León: Número 244 - 1963 octubre 29 (29/10/1963)

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2011-201

Donor human milk protects against bronchopulmonary dysplasia: A systematic review and meta-analysis

Bronchopulmonary dysplasia (BPD) is the most common complication after preterm birth. Pasteurized donor human milk (DHM) has increasingly become the standard of care for very preterm infants over the use of preterm formula (PF) if the mother\u2019s own milk (MOM) is unavailable. Studies have reported beneficial effects of DHM on BPD. We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) and observational studies on the effects of DHM on BPD and other respiratory outcomes. Eighteen studies met the inclusion criteria. Meta-analysis of RCTs could not demonstrate that supplementation of MOM with DHM reduced BPD when compared to PF (three studies, risk ratio (RR) 0.89, 95% confidence interval (CI) 0.60-1.32). However, meta-analysis of observational studies showed that DHM supplementation reduced BPD (8 studies, RR 0.78, 95% CI 0.67-0.90). An exclusive human milk diet reduced the risk of BPD, compared to a diet with PF and/or bovine milk-based fortifier (three studies, RR 0.80, 95% CI 0.68-0.95). Feeding raw MOM, compared to feeding pasteurized MOM, protected against BPD (two studies, RR 0.77, 95% CI 0.62-0.96). In conclusion, our data suggest that DHM protects against BPD in very preterm infants

Seismic response to evolving injection at the Rotokawa geothermal field, New Zealand

Catalogs of microseismicity are routinely compiled at geothermal reservoirs and provide valuable insights into reservoir structure and fluid movement. Hypocentral locations are typically used to infer the orientations of structures and constrain the extent of the permeable reservoir. However, frequency-magnitude distributions may contain additional, and underused, information about the distribution of pressure. Here, we present a four-year catalog of seismicity for the Rotokawa geothermal field in the central Taupō Volcanic Zone, New Zealand starting two years after the commissioning of the 140 MWe Nga Awa Purua power station. Using waveform-correlation-based signal detection we double the size of the previous earthquake catalog, refine the location and orientation of two reservoir faults and identify a new structure. We find the rate of seismicity to be insensitive to major changes in injection strategy during the study period, including the injectivity decline and shift of injection away from the dominant injector, RK24. We also map the spatial distribution of the earthquake frequency-magnitude distribution, or b-value, and show that it increases from ∼1.0 to ∼1.5 with increasing depth below the reservoir. As has been proposed at other reservoirs, we infer that these spatial variations reflect the distribution of pressure in the reservoir, where areas of high b-value correspond to areas of high pore-fluid pressure and a broad distribution of activated fractures. This analysis is not routinely conducted by geothermal operators but shows promise for using earthquake b-value as an additional tool for reservoir monitoring and management

Floristic Inventory of The Proposed Site for Tarsier Tourism Center in Villa Aurora, Bilar, Bohol, Philippines

The study assessed the present vegetation composition of the Proposed Site for the Tarsier Tourism Center (PTTC) at Villa Aurora, Bilar, Bohol and performed a comparative analysis with the existing Tarsier Sanctuary (TS) at Canapnapan, Corella, Bohol. The basis for comparison was the computed importance values, species richness, species dominance, and percent distribution of plants according to self-defined DBH classes. Results showed that both sites had very high species richness and evenness values. Common overstorey and understorey plant species found in both areas were katagpo (Psychotria sp.), sagimsim (Syzygium brevistylum [C. B. Rob]Merr.) and bagauak (Clerodendrum minahassae Teijsm. & Binn.). Apart from sagimsim (Syzygium brevistylum [C.B.Rob.] Merr.), selaginella (Selaginella cuppresina Lin.), and lunas (Lunasia amara Blanco) were also common in the ground vegetation of both areas. Percent distribution of trees according to self-defined DBH classes revealed that PTTC had 87.55% of the total recorded plants with DBH measurements of 20 cm. Percent distribution of trees on these DBH ranges (especially on DBH class >20 cm) indicated the presence of medium and large trees. The largest DBH measured in the PTTC was 70 cm while in TS was only 22 cm. The proposed 10-ha site in Villa Aurora, Bilar, is suited to be utilized as Tarsier Tourism Center. In case the proposed project is to be pursued, enclosure similar to what has been constructed in Canapnapan, Corella, Bohol, Philippines should also be established to prevent stray animals from predating the captive tarsiers.Keywords: floristic inventory, Philippine tarsier, Bohol, primate conservation, tourism. Inventarisasi flora dari Situs Usulan untuk Sentra Wisata Tarsier di Villa Aurora, Bilar, Bohol, FilipinaAbstractPenelitian ini ditujukan untuk melakukan penilaian komposisi vegetasi dari Usulan Lokasi Pusat Wisata Tarsius (ULPWT) di Villa Aurora, Bilar, Bohol dan melakukan analisis perbandingan antara Tarsier Sanctuary (TS) yang ada di Canapnapan, Corella, Bohol. Dasar perbandingan yang digunakan yaitu dengan menghitung nilai penting, kekayaan spesies, dominansi spesies, dan prosentase distribusi dari tumbuhan berdasarkan kelas diameter yang telah ditentukan. Hasil penelitian menunjukkan bahwa kedua tempat memiliki kekayaan spesies dan nilai evenness/ kemerataan yang sangat tinggi. Spesies tumbuhan yang umum ditemukan di overstorey dan understorey di kedua area adalah katagpo (Psychotria sp.), sagimsim (Syzygium brevistylum [C. B. Rob]Merr.), dan bagauak (Clerodendrum minahassae Teijsm. & Binn.). Selain itu, sagimsim (Syzygium brevistylum [C.B.Rob.] Merr.), selaginella (Selaginella cuppresina Lin.), dan lunas (Lunasia amara Blanco) juga umum ditemukan di lantai hutan di kedua tempat. Prosentase distribusi dari tumbuhan berdasarkan kelas diameter yang telah ditentukan menunjukkan bahwa ULPWT memiliki 87.55% dari keseluruhan tumbuhan yang tercatat dengan ukuran diameter 20 cm. Prosentase distribusi dari pohon pada kisaran ini (khususnya pada diameter >20 cm) menunjukkan adanya kehadiran pohon berukuran medium dan besar. Diameter terbesar yang terukur di ULPWT adalah 70 cm sementara di TS hanya sebesar 22 cm. Lokasi seluas 10 ha di Villa Aurora, Bilar, sesuai untuk digunakan sebagai Pusat Wisata Tarsius. Apabila akan didirikan, maka kandang yang dibangun diharapkan mirip dengan yang telah dibangun di Canapnapan, Corella, Bohol, Pilipina, agar mencegah pemangsaan oleh satwa yang lepas.

Detection of chromothripsis-like patterns with a custom array platform for chronic lymphocytic leukemia

This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License.-- et al.Chronic lymphocytic leukemia (CLL) is a common disease with highly variable clinical course. Several recurrent chromosomal alterations are associated with prognosis and may guide risk-adapted therapy. We have developed a targeted genome-wide array to provide a robust tool for ascertaining abnormalities in CLL and to overcome limitations of the 4-marker fluorescence in situ hybridization (FISH). DNA from 180 CLL patients were hybridized to the qChip®Hemo array with a high density of probes covering commonly altered loci in CLL (11q22-q23, 13q14, and 17p13), nine focal regions (2p15-p16.1, 2p24.3, 2q13, 2q36.3-q37.1, 3p21.31, 8q24.21, 9p21.3, 10q24.32, and 18q21.32-q21.33) and two larger regions (6q14.1-q22.31 and 7q31.33-q33). Overall, 86% of the cases presented copy number alterations (CNA) by array. There was a high concordance of array findings with FISH (84% sensitivity, 100% specificity); all discrepancies corresponded to subclonal alterations detected only by FISH. A chromothripsis-like pattern was detected in eight cases. Three showed concomitant shattered 5p with gain of TERT along with isochromosome 17q. Presence of 11q loss was associated with shorter time to first treatment (P=0.003), whereas 17p loss, increased genomic complexity, and chromothripsis were associated with shorter overall survival (P<0.001, P=0.001, and P=0.02, respectively). In conclusion, we have validated a targeted array for the diagnosis of CLL that accurately detects, in a single experiment, all relevant CNAs, genomic complexity, chromothripsis, copy number neutral loss of heterozygosity, and CNAs not covered by the FISH panel. This test may be used as a practical tool to stratify CLL patients for routine diagnostics or clinical trials.Supported by: Fondo de Investigaciones Sanitarias, Instituto de Salud Carlos III (ISCIII), Grant numbers: PI11/01177, PI14/00571; Worldwide Cancer Research; Grant number: 12-0142; Marato de TV3; Grant number: TV3-Cancer/2013410; Generalitat de Catalunya Suport Grups de Recerca; Grant number: 2013-SGR-378; Red Tematica de Investigacion Cooperativa en Cancer (RTICC), Grant numbers: RD12/0036/0036, RD12/0036/0023, RD12/0036/0004, RD12/0036/0069; Subprograma Juan de la Cierva, Grant number: JCI-2011-10232; Miguel Servet Contract, Grant number: CP13/00159; the Spanish Ministry of Science and Innovation (MICINN) through the ISCIII —International Cancer Genome Consortium for Chronic Lymphocytic Leukemia (ICGC-CLL Genome Project); Institucio Catalana de Recerca i Estudis Avançats” (ICREA) of the Generalitat de Catalunya; European Regional Development Fund “Una manera de fer Europa”; Alexander von Humboldt Post-doctoral Fellowship.Peer Reviewe

Boletín oficial de la provincia de León: Num. 24 (23/08/1895)

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2011-201

Boletín oficial de la provincia de León: Num. 24 (23/08/1895)

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2011-201

Boletín oficial de la provincia de León: Num. 24 (23/08/1895)

Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2011-201