2,299 research outputs found
Strand plasticity governs fatigue in colloidal gels
Repeated loading of a solid leads to microstructural damage that ultimately
results in catastrophic material failure. While posing a major threat to the
stability of virtually all materials, the microscopic origins of fatigue,
especially for soft solids, remain elusive. Here we explore fatigue in
colloidal gels as prototypical inhomogeneous soft solids by combining
experiments and computer simulations. Our results reveal how mechanical loading
leads to irreversible strand stretching, which builds slack into the network
that softens the solid at small strains and causes strain hardening at larger
deformations. We thus find that microscopic plasticity governs fatigue at much
larger scales. This gives rise to a new picture of fatigue in soft thermal
solids and calls for new theoretical descriptions of soft gel mechanics in
which local plasticity is taken into account.Comment: 5 pages, 4 figure
An audio FIR-DAC in a BCD process for high power Class-D amplifiers
A 322 coefficient semi-digital FIR-DAC using a 1-bit PWM input signal was designed and implemented in a high voltage, audio power bipolar CMOS DMOS (BCD) process. This facilitates digital input signals for an analog class-D amplifier in BCD. The FIR-DAC performance depends on the ISI-resistant nature of this PWM-signal. An impulse response with only positive coefficients was chosen, because of its resistance to deadzone and mismatch. With a DAC current of 0.5 mA, the dynamic range is 111 dB (A-weighted), with SINAD = 103 dB (A-weighted). The current consumption is 1mA for the analog part and 4.8 mA for the digital part. The power consumption is 29 mW at V/sub dd/ = 5 V and the chip area is 2 mm/sup 2/ including the reference diode that can be shared by more channels
Quorum sensing as a mechanism to harness the wisdom of the crowds
Bacteria release and sense small molecules called autoinducers in a process known as quorum sensing. The prevailing interpretation of quorum sensing is that by sensing autoinducer concentrations, bacteria estimate population density to regulate the expression of functions that are only beneficial when carried out by a sufficiently large number of cells. However, a major challenge to this interpretation is that the concentration of autoinducers strongly depends on the environment, often rendering autoinducer-based estimates of cell density unreliable. Here we propose an alternative interpretation of quorum sensing, where bacteria, by releasing and sensing autoinducers, harness social interactions to sense the environment as a collective. Using a computational model we show that this functionality can explain the evolution of quorum sensing and arises from individuals improving their estimation accuracy by pooling many imperfect estimates – analogous to the ‘wisdom of the crowds’ in decision theory. Importantly, our model reconciles the observed dependence of quorum sensing on both population density and the environment and explains why several quorum sensing systems regulate the production of private goods.</p
Helicobacter Genotyping and Detection in Peroperative Lavage Fluid in Patients with Perforated Peptic Ulcer
Introduction and Objectives Certain Helicobacter pylori genotypes are associated with peptic ulcer disease; however, little is known about associations between the H. pylori genotype and perforated peptic ulcer (PPU). The primary aim of this study was to evaluate which genotypes are present in patients with PPU and which genotype is dominant in this population. The secondary aim was to study the possibility of determining the H. pylori status in a way other than by biopsy.
Materials and Methods Serum samples, gastric tissue biopsies, lavage fluid, and fluid from the nasogastric tube were collec
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