Massey products in symplectic manifolds

The paper is devoted to study of Massey products in symplectic manifolds. Theory of generalized and classical Massey products and a general construction of symplectic manifolds with nontrivial Massey products of arbitrary large order are exposed. The construction uses the symplectic blow-up and is based on the author results, which describe conditions under which the blow-up of a symplectic manifold X along its submanifold Y inherits nontrivial Massey products from X ot Y. This gives a general construction of nonformal symplectic manifolds.Comment: LaTeX, 48 pages, 2 figure

A dynamic analysis of the incidence rate in adolescents of the Russian Federation and Novosibirsk Region

By means of calculation of the incidence mean value, the amplitude of oscillation and a dynamic analysis, we investigated data from official statistical collections of the Federal State Statistics Service (Public Health in Russia, Russian Statistical Yearbook). We assessed the incidence rate using medical aid appealability of adolescents (15-І7 years) in the Russian Federation and Novosibirsk region during the period from 2004 to 2013. A comparative dynamic analysis of general incidence of the adolescents of the Russian Federation and Novosibirsk region has shown that the medical referral level is higher in the Russian Federation by 33.8 % with an average increase by 3.4 % per year on average, especially for such types of diseases as digestive diseases, diseases of the endocrine system, diseases of the musculoskeletal system and connective tissue, circulatory system diseases, diseases of the eye and adnexa, diseases of the ear and mastoid process, nervous system diseases (44.1 %; 31.9 %; 26.0 %; 24.9 %; 23.8 %; 22.9 %; 21.3 %; 19.8 % respectively); the medical referral level of Novosibirsk region was higher by 30.2 % with an average increase by 3.0 % per year on average, infectious and parasitic pathology was higher by 43.0 % mainly. The differences in the levels of medical help and the structure of the main types of diseases that determine the nature of adolescent morbidity in the Russian Federation and Novosibirsk region, which predetermines the need to ensure appropriate coordination of medical activities and services

Haplotype analysis of APOE intragenic SNPs

BACKGROUND: APOE epsilon4 allele is most common genetic risk factor for Alzheimer\u27s disease (AD) and cognitive decline. However, it remains poorly understood why only some carriers of APOE epsilon4 develop AD and how ethnic variabilities in APOE locus contribute to AD risk. Here, to address the role of APOE haplotypes, we reassessed the diversity of APOE locus in major ethnic groups and in Alzheimer\u27s Disease Neuroimaging Initiative (ADNI) dataset on patients with AD, and subjects with mild cognitive impairment (MCI), and control non-demented individuals. RESULTS: We performed APOE gene haplotype analysis for a short block of five SNPs across the gene using the ADNI whole genome sequencing dataset. The compilation of ADNI data with 1000 Genomes identified the APOE epsilon4 linked haplotypes, which appeared to be distant for the Asian, African and European populations. The common European epsilon4-bearing haplotype is associated with AD but not with MCI, and the Africans lack this haplotype. Haplotypic inference revealed alleles that may confer protection against AD. By assessing the DNA methylation profile of the APOE haplotypes, we found that the AD-associated haplotype features elevated APOE CpG content, implying that this locus can also be regulated by genetic-epigenetic interactions. CONCLUSIONS: We showed that SNP frequency profiles within APOE locus are highly skewed to population-specific haplotypes, suggesting that the ancestral background within different sites at APOE gene may shape the disease phenotype. We propose that our results can be utilized for more specific risk assessment based on population descent of the individuals and on higher specificity of five site haplotypes associated with AD

Physicochemical aspects of recycling tree leaf litter in the south of Western Siberia by the Eisenia fetida (Savigny) vermiculture

The utility of the compost worm Eisenia fetida (Savigny) for recycling mixed leaf litter of the tree species characteristic of the forests in the south of Western Siberia and used in the landscaping in the city of Tomsk has been demonstrated. The tree species that are the major contributors to the leaf litter in the examined area include the genera Populus, Salix, and Betula. Two-fraction substrates for leaf litter vermicomposting and conventional composting (decomposition with and without earthworms) were prepared of the harvested and dried leaf litter. The feeding fraction consisted of leaf litter moistened with distilled water and the absorbing fraction, of alluvial river sand. The physicochemical properties of the studied leaf litter were weakly acidic pH of aqueous extracts, a very low content of nitrate nitrogen, and a relatively low K + concentration. The prevalent cation in the assayed leaf litter was Ca 2+ . The leaf litter was partially decomposed on the surface of sand substrates during 35-day incubation under humid conditions; accumulation of inorganic ions in the sand was one of the signs indicating this decomposition. Ca 2+ was also prevalent among these ions

Genetic environment of the blaKPC-2 gene in a Klebsiella pneumoniae isolate that may have been imported to Russia from Southeast Asia

The nucleotide sequence of a blaKPC-2-harboring plasmid (pKPCAPSS) from Klebsiella pneumoniae ST273 isolated in Saint Petersburg, Russia, from a patient with history of recent travel to Vietnam is presented. This 127,970-bp plasmid possessed both IncFII and IncR replicons. blaKPC-2 was localized on a hypothetical mobile element. This element was flanked by 38-bp inverted Tn3 repeats and included a Tn3-specific transposase gene, macrolide resistance operon (mphA-mrx-mphR), and a fragment of blaTEM with unique polymorphisms. © 2017 American Society for Microbiology. All Rights Reserved

The Blogosphere as a Specific Area of Digital Communication

This article examines the specifics of the blogosphere of the Russian-speaking segment of the Internet, as well as the changes that have occurred in this area after the ban of certain social platforms and their recognition as extremist on the territory of the Russian Federation. The study was carried out using a comparative method and is based on the analysis of the content of blogs in the social networks VKontakte, Dzen, Telegram, selected by a continuous sampling method for the period from February 2022 to October 2022. The blogosphere today is a dynamically and actively developing environment, and blogs are no longer just a channel for broadcasting relevant information, but also a social and communicative phenomenon existing at the intersection of journalism, marketing and political technologies.The recognition of some popular social networks as extremist on the territory of the Russian Federation has led to a reduction in the income of bloggers associated with a sharp decrease in the coverage of their accounts, as well as the departure of a number of major foreign advertisers from the Russian market. There was a transition of the main bloggers to alternative blogging platforms, as well as the search for suitable forms of content submission for them and attempts to increase the audience. These changes affected not only bloggers, but also the accounts of various state budget organizations operating within the framework of the electronic state presented on the Internet.Social networks today are turning from platforms for communication and file sharing into digital ecosystems that include many services. Bloggers develop their accounts, increasing the number of subscribers and building up a regular audience and become influencers — opinion leaders, which is actively used by businesses in influencer marketing. To optimize cooperation with media personalities who have their own blogs, representatives of companies turn to influencer agencies, which today provide a full range of digital services, from the idea to its final implementation. The growth of the older audience leads to the fact that the content is “maturing” — more and more serious topics are being raised, the requirements for the quality of content are increasing. The trends of personalization of content and fragmentation of the blog audience are also increasing

The Hilbert-Schmidt Theorem Formulation of the R-Matrix Theory

Using the Hilbert-Schmidt theorem, we reformulate the R-matrix theory in terms of a uniformly and absolutely convergent expansion. Term by term differentiation is possible with this expansion in the neighborhood of the surface. Methods for improving the convergence are discussed when the R-function series is truncated for practical applications.Comment: 16 pages, Late

Возможности диагностики редких видов соколов рода Falco по микроструктуре первостепенных маховых перьев

The paper reports on the original findings of scanning electron microscope comparison of the fine structure of primary remiges inFalco rusticolus, F. cherrug, F. peregrinus, and F. rusticolus х F. cherrug. The study identified a number of species-specific microstructural characteristics that show a high diagnostic potential for taxonomic identifications in forensic biology.Представлены результаты сравнительного электронно-микроскопического исследования строения первостепенных маховых перьев кречета (Falco rusticolus), балобана (F. cherrug), сапсана (F. peregrinus) и гибридной особи (F. rusticolus х F. cherrug). Выявлен ряд видоспецифических микроструктурных характеристик, что существенно расширяет потенциальные возможности пера для целей судебно-биологической экспертизы