New Axial Interactions at a TeV

We consider a heavy fourth family with masses lying in the symmetry breaking channel of a new strong gauge interaction. This interaction generates a heavy quark axial-type operator, whose effects can be enhanced through multiple insertions. In terms of the strength of this operator we can express new negative contributions to the S and T parameters and the shifts of the Z couplings to the third family. In particular we find that the new contribution to T is strongly constrained by the experimental constraints on the Z coupling to the tau.Comment: 14 pages, 1 figure, PRD versio

Supersymmetry and Stationary Solutions in Dilaton-Axion Gravity

New stationary solutions of $4$-dimensional dilaton-axion gravity are presented, which correspond to the charged Taub-NUT and Israel-Wilson-Perjes (IWP) solutions of Einstein-Maxwell theory. The charged axion-dilaton Taub-NUT solutions are shown to have a number of interesting properties: i) manifest $SL(2,R)$ symmetry, ii) an infinite throat in an extremal limit, iii) the throat limit coincides with an exact CFT construction. The IWP solutions are shown to admit supersymmetric Killing spinors, when embedded in $d=4,N=4$ supergravity. This poses a problem for the interpretation of supersymmetric rotating solutions as physical ground states. In the context of $10$-dimensional geometry, we show that dimensionally lifted versions of the IWP solutions are dual to certain gravitational waves in string theory.Comment: 23 pages (latex), SU-ITP-94-12, UMHEP-407, QMW-PH-94-1

Creation of ultracold molecules from a Fermi gas of atoms

Since the realization of Bose-Einstein condensates (BEC) in atomic gases an experimental challenge has been the production of molecular gases in the quantum regime. A promising approach is to create the molecular gas directly from an ultracold atomic gas; for example, atoms in a BEC have been coupled to electronic ground-state molecules through photoassociation as well as through a magnetic-field Feshbach resonance. The availability of atomic Fermi gases provides the exciting prospect of coupling fermionic atoms to bosonic molecules, and thus altering the quantum statistics of the system. This Fermi-Bose coupling is closely related to the pairing mechanism for a novel fermionic superfluid proposed to occur near a Feshbach resonance. Here we report the creation and quantitative characterization of exotic, ultracold $^{40}$K$_2$ molecules. Starting with a quantum degenerate Fermi gas of atoms at T < 150 nanoKelvin we scan over a Feshbach resonance to adiabatically create over a quarter million trapped molecules, which we can convert back to atoms by reversing the scan. The small binding energy of the molecules is controlled by detuning from the Feshbach resonance and can be varied over a wide range. We directly detect these weakly bound molecules through rf photodissociation spectra that probe the molecular wavefunction and yield binding energies that are consistent with theory

Structural and biochemical characterization of the exopolysaccharide deacetylase Agd3 required for Aspergillus fumigatus biofilm formation

The exopolysaccharide galactosaminogalactan (GAG) is an important virulence factor of the fungal pathogen Aspergillus fumigatus. Deletion of a gene encoding a putative deacetylase, Agd3, leads to defects in GAG deacetylation, biofilm formation, and virulence. Here, we show that Agd3 deacetylates GAG in a metal-dependent manner, and is the founding member of carbohydrate esterase family CE18. The active site is formed by four catalytic motifs that are essential for activity. The structure of Agd3 includes an elongated substrate-binding cleft formed by a carbohydrate binding module (CBM) that is the founding member of CBM family 87. Agd3 homologues are encoded in previously unidentified putative bacterial exopolysaccharide biosynthetic operons and in other fungal genomes. The exopolysaccharide galactosaminogalactan (GAG) is an important virulence factor of the fungal pathogen Aspergillus fumigatus. Here, the authors study an A. fumigatus enzyme that deacetylates GAG in a metal-dependent manner and constitutes a founding member of a new carbohydrate esterase family.Bio-organic Synthesi

The Higgs resonance in vector boson scattering

A heavy Higgs resonance is described in a representation-independent way which is valid for the whole energy range of 2 -> 2 scattering processes, including the asymptotic behavior at low and high energies. The low-energy theorems which follow from to the custodial SU_2 symmetry of the Higgs sector restrict the possible parameterizations of the lineshape that are consistent in perturbation theory. Matching conditions are specified which are necessary and sufficient to relate the parameters arising in different expansions. The construction is performed explicitly up to next-to-leading order.Comment: 25 pages, revtex, uses epsf, amssym

Lipocalin-7 Is a Matricellular Regulator of Angiogenesis

Matricellular proteins are extracellular regulators of cellular adhesion, signaling and performing a variety of physiological behaviors such as proliferation, migration and differentiation. Within vascular microenvironments, matricellular proteins exert both positive and negative regulatory cues to vascular endothelium. The relative balance of these matricellular cues is believed to be critical for vascular homeostasis, angiogenesis activation or angiogenesis resolution. However, our knowledge of matricellular proteins within vascular microenvironments and the mechanisms by which these proteins impact vascular function remain largely undefined. The matricellular protein lipocalin-7 (LCN7) is found throughout vascular microenvironments, and circumstantial evidence suggests that LCN7 may be an important regulator of angiogenesis. Therefore, we hypothesized that LCN7 may be an important regulator of vascular function.To test this hypothesis, we examined the effect of LCN7 overexpression, recombinant protein and gene knockdown in a series of in vitro and in vivo models of angiogenesis. We found that overexpression of LCN7 in MB114 and SVEC murine endothelial cell lines or administration of highly purified recombinant LCN7 protein increased endothelial cell invasion. Similarly, LCN7 increased angiogenic sprouting from quiescent endothelial cell monolayers and ex vivo aortic rings. Moreover, LCN7 increased endothelial cell sensitivity to TGF-β but did not affect sensitivity to other pro-angiogenic growth factors including bFGF and VEGF. Finally, morpholino based knockdown of LCN7 in zebrafish embryos specifically inhibited angiogenic sprouting but did not affect vasculogenesis within injected embryos.No functional analysis has previously been performed to elucidate the function of LCN7 in vascular or other cellular processes. Collectively, our results show for the first time that LCN7 is an important pro-angiogenic matricellular protein of vascular microenvironments

Strongly Interacting Vector Bosons at TeV e+-e- Linear Colliders

In the absence of light Higgs bosons, the W and Z bosons become strongly interacting particles at energies of about 1 TeV. If the longitudinal W,Z components are generated by Goldstone modes associated with spontaneous symmetry breaking in a new strong interaction theory, the quasi-elastic W,Z scattering amplitudes can be predicted as a systematic chiral expansion in the energy. We study the potential of TeV e+e- and e-e- linear colliders in investigating these scattering processes. We estimate the accuracy with which the coefficients of the chiral expansion can be measured in a multi-parameter analysis. The measurements will provide us with a quantitative test of the dynamics underlying the W,Z interactions.Comment: 40 pages, LaTeX2e, uses feynmp.sty [included]. Improvements in text, minor typos correcte

FERTILISATION STRATEGIES ACROSS EUROPE: CURRENT SITUATION, POTENTIAL AND LIMITS FOR A HARMONISED APPROACH

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