562 research outputs found
Safety and pharmacological efficiency (influence on muscular dysfunction) of new derivatives of chromon-3-aldehyde
Objective: to estimate the safety of application of new derivatives of chromon-3-aldehyde and the possibility of its application for correction of muscular dysfunction. Materials and methods: the experiment was performed on 120 mice-males of the Balb/c line. Research objects - halogenated derivatives of chromon-3-aldehyde under codes of X3AF and X3ACl. The safety assessment of its application included the determination ofits single dose toxicity with calculation of LD50 using the Finni method. Further, the influence of derivatives on the development of muscular dysfunction using the myostimmulation test after its preventive introduction was studied. Results: the conducted research showed that new halogenated derivatives of chromon-3-aldehyde under codes of X3AF and X3ACl possessed an optimum profile of safety and wereable to alleviate the manifestations of muscle dysfunction. At the same time the substanceX3AF surpassed the substance X3ACl and comparison drug «Mildronat» in the size of pharmacological action. Conclusions: the low toxicity and high pharmacological efficiency of new halogenated derivatives of chromon-3-aldehyde makes these compounds the perspective o
Quantum Criticality via Magnetic Branes
Holographic methods are used to investigate the low temperature limit,
including quantum critical behavior, of strongly coupled 4-dimensional gauge
theories in the presence of an external magnetic field, and finite charge
density. In addition to the metric, the dual gravity theory contains a Maxwell
field with Chern-Simons coupling. In the absence of charge, the magnetic field
induces an RG flow to an infrared AdS geometry, which is
dual to a 2-dimensional CFT representing strongly interacting fermions in the
lowest Landau level. Two asymptotic Virasoro algebras and one chiral Kac-Moody
algebra arise as {\sl emergent symmetries} in the IR. Including a nonzero
charge density reveals a quantum critical point when the magnetic field reaches
a critical value whose scale is set by the charge density. The critical theory
is probed by the study of long-distance correlation functions of the boundary
stress tensor and current. All quantities of major physical interest in this
system, such as critical exponents and scaling functions, can be computed
analytically. We also study an asymptotically AdS system whose magnetic
field induced quantum critical point is governed by a IR Lifshitz geometry,
holographically dual to a D=2+1 field theory. The behavior of these holographic
theories shares important similarities with that of real world quantum critical
systems obtained by tuning a magnetic field, and may be relevant to materials
such as Strontium Ruthenates.Comment: To appear in Lect. Notes Phys. "Strongly interacting matter in
magnetic fields" (Springer), edited by D. Kharzeev, K. Landsteiner, A.
Schmitt, H.-U. Ye
Finite temperature phase transition for disordered weakly interacting bosons in one dimension
It is commonly accepted that there are no phase transitions in
one-dimensional (1D) systems at a finite temperature, because long-range
correlations are destroyed by thermal fluctuations. Here we demonstrate that
the 1D gas of short-range interacting bosons in the presence of disorder can
undergo a finite temperature phase transition between two distinct states:
fluid and insulator. None of these states has long-range spatial correlations,
but this is a true albeit non-conventional phase transition because transport
properties are singular at the transition point. In the fluid phase the mass
transport is possible, whereas in the insulator phase it is completely blocked
even at finite temperatures. We thus reveal how the interaction between
disordered bosons influences their Anderson localization. This key question,
first raised for electrons in solids, is now crucial for the studies of atomic
bosons where recent experiments have demonstrated Anderson localization in
expanding very dilute quasi-1D clouds.Comment: 8 pages, 5 figure
Cymantrene–Triazole "Click" Products: Structural Characterization and Electrochemical Properties
We report the first known examples of triazole-derivatized cymantrene complexes (η5-[4-substituted triazol-1-yl]cyclopentadienyl)tricarbonylmanganese(I), obtained via a “click” chemical synthesis, bearing a phenyl, 3-aminophenyl, or 4-aminophenyl moiety at the 4-position of the triazole ring. Structural characterization data using multinuclear NMR, UV–vis, ATR-IR, and mass spectrometric methods are provided, as well as crystallographic data for (η5-[4-phenyltriazol-1-yl]cyclopentadienyl)tricarbonylmanganese(I) and (η5-[4-(3-aminophenyl)triazol-1-yl]cyclopentadienyl)tricarbonylmanganese(I). Cyclic voltammetric characterization of the redox behavior of each of the three cymantrene–triazole complexes is presented together with digital simulations, in situ infrared spectroelectrochemistry, and DFT calculations to extract the associated kinetic and thermodynamic parameters. The trypanocidal activity of each cymantrene–triazole complex is also examined, and these complexes are found to be more active than cymantrene alone
Quantum melting of incommensurate domain walls in two dimensions
Quantum fluctuations of periodic domain-wall arrays in two-dimensional
incommensurate states at zero temperature are investigated using the elastic
theory in the vicinity of the commensurate-incommensurate transition point.
Both stripe and honeycomb structures of domain walls with short-range
interactions are considered. It is revealed that the stripes melt and become a
stripe liquid in a large-wall-spacing (low-density) region due to dislocations
created by quantum fluctuations. This quantum melting transition is of second
order and characterized by the three-dimensional XY universality class.
Zero-point energies of the stripe and honeycomb structures are calculated. As a
consequence of these results, phase diagrams of the domain-wall solid and
liquid phases in adsorbed atoms on graphite are discussed for various
domain-wall masses. Quantum melting of stripes in the presence of long-range
interactions that fall off as power laws is also studied. These results are
applied to incommensurate domain walls in two-dimensional adsorbed atoms on
substrates and in doped antiferromagnets, e.g. cuprates and nickelates.Comment: 11 pages, 5 figure
Photoemission "experiments" on holographic superconductors
We study the effects of a superconducting condensate on holographic Fermi
surfaces. With a suitable coupling between the fermion and the condensate,
there are stable quasiparticles with a gap. We find some similarities with the
phenomenology of the cuprates: in systems whose normal state is a non-Fermi
liquid with no stable quasiparticles, a stable quasiparticle peak appears in
the condensed phase.Comment: 14 pages, 13 figures; v2: typos corrected and some clarification
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Strongly coupled quantum criticality with a Fermi surface in two dimensions: fractionalization of spin and charge collective modes
We describe two dimensional models with a metallic Fermi surface which
display quantum phase transitions controlled by strongly interacting critical
field theories below their upper critical dimension. The primary examples
involve transitions with a topological order parameter associated with
dislocations in collinear spin density wave ("stripe") correlations: the
gapping of the order parameter fluctuations leads to a fractionalization of
spin and charge collective modes, and this transition has been proposed as a
candidate for the cuprates near optimal doping. The coupling between the order
parameter and long-wavelength volume and shape deformations of the Fermi
surface is analyzed by the renormalization group, and a runaway flow to a
non-perturbative regime is found in most cases. A phenomenological scaling
analysis of simple observable properties of possible second order quantum
critical points is presented, with results quite similar to those near quantum
spin glass transitions and to phenomenological forms proposed by Schroeder et
al. (cond-mat/0011002).Comment: 16 pages, 4 figures; (v2) additional clarifying remark
An Electrochemical Study of Frustrated Lewis Pairs: A Metal-free Route to Hydrogen Oxidation
[Image: see text] Frustrated Lewis pairs have found many applications in the heterolytic activation of H(2) and subsequent hydrogenation of small molecules through delivery of the resulting proton and hydride equivalents. Herein, we describe how H(2) can be preactivated using classical frustrated Lewis pair chemistry and combined with in situ nonaqueous electrochemical oxidation of the resulting borohydride. Our approach allows hydrogen to be cleanly converted into two protons and two electrons in situ, and reduces the potential (the required energetic driving force) for nonaqueous H(2) oxidation by 610 mV (117.7 kJ mol(–1)). This significant energy reduction opens routes to the development of nonaqueous hydrogen energy technology
Probing a Complex of Cytochromecand Cardiolipin by Magnetic Circular Dichroism Spectroscopy: Implications for the Initial Events in Apoptosis
Oxidation of cardiolipin (CL) by its complex with cytochrome c (cyt c) plays a crucial role in triggering apoptosis. Through a combination of magnetic circular dichroism spectroscopy and potentiometric titrations, we show that both the ferric and ferrous forms of the heme group of a CL:cyt c complex exist as multiple conformers at a physiologically relevant pH of 7.4. For the ferric state, these conformers are His/Lys- and His/OH–-ligated. The ferrous state is predominantly high-spin and, most likely, His/–. Interconversion of the ferric and ferrous conformers is described by a single midpoint potential of -80 ± 9 mV vs SHE. These results suggest that CL oxidation in mitochondria could occur by the reaction of molecular oxygen with the ferrous CL:cyt c complex in addition to the well-described reaction of peroxides with the ferric form
Spontaneous breaking of four-fold rotational symmetry in two-dimensional electronic systems explained as a continuous topological transition
The Fermi liquid approach is applied to the problem of spontaneous violation
of the four-fold rotational point-group symmetry () in strongly correlated
two-dimensional electronic systems on a square lattice. The symmetry breaking
is traced to the existence of a topological phase transition. This continuous
transition is triggered when the Fermi line, driven by the quasiparticle
interactions, reaches the van Hove saddle points, where the group velocity
vanishes and the density of states becomes singular. An unconventional Fermi
liquid emerges beyond the implicated quantum critical point.Comment: 6 pages, 4 figure
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