The morphology and application of stem cells in digestive system surgery

Background: Stem cells constitute a group of cells which possess the ability to self-renew as well as the capacity to differentiate into a vast number of different cells within the human organism. Moreover, stem cells are able to undergo a potentially unlimited number of divisions and this characteristic is clinically essential. Specific fields of its application include treatment of diseases mainly in the field of haematology, orthopaedics, surgery, dentistry, and neurology. Materials and methods: In the following work, the current knowledge concerning mechanisms of stem cell treatment in different parts of the digestive system with its diseases as well as adjacent therapy for surgery has been revised. Results: Stem cells therapy may be used in the treatment of various diseases of different parts of the digestive system. This also applies to the end part of the digestive tract (proctological diseases) because stem cells can be used to treat fistulas. Liposuction allows more recovery of mesenchymal stem cells, compared to previous bone marrow harvesting methods. Despite the application of stem cells in the treatment of different diseases used for many years so far, the therapeutic use for the regeneration of the gastrointestinal tract is still rare and unfamiliar. Conclusions: Regenerative medicine seems to be a promising tool in medical research, especially when insulated cells and designed biomaterials are taken into consideration. Major points of discussion include types of stem cells, their origin or differentiation for the treatment of many diseases

Immunological aspects of the tumor microenvironment and epithelial-mesenchymal transition in gastric carcinogenesis

Infection with Helicobacter pylori, a Gram-negative, microaerophilic pathogen often results in gastric cancer in a subset of affected individuals. This explains why H. pylori is the only bacterium classified as a class I carcinogen by the World Health Organization. Several studies have pinpointed mechanisms by which H. pylori alters signaling pathways in the host cell to cause diseases. In this article, the authors have reviewed 234 studies conducted over a span of 18 years (2002–2020). The studies investigated the various mechanisms associated with gastric cancer induction. For the past 1.5 years, researchers have discovered new mechanisms contributing to gastric cancer linked to H. pylori etiology. Alongside alteration of the host signaling pathways using oncogenic CagA pathways, H. pylori induce DNA damage in the host and alter the methylation of DNA as a means of perturbing downstream signaling. Also, with H. pylori, several pathways in the host cell are activated, resulting in epithelial-to-mesenchymal transition (EMT), together with the induction of cell proliferation and survival. Studies have shown that H. pylori enhances gastric carcinogenesis via a multifactorial approach. What is intriguing is that most of the targeted mechanisms and pathways appear common with various forms of cancer

Mechanisms of the Epithelial-Mesenchymal Transition and Tumor Microenvironment in Helicobacter pylori-Induced Gastric Cancer

Helicobacter pylori (H. pylori) is one of the most common human pathogens, affecting half of the world's population. Approximately 20% of the infected patients develop gastric ulcers or neoplastic changes in the gastric stroma. An infection also leads to the progression of epithelial-mesenchymal transition within gastric tissue, increasing the probability of gastric cancer development. This paper aims to review the role of H. pylori and its virulence factors in epithelial-mesenchymal transition associated with malignant transformation within the gastric stroma. The reviewed factors included: CagA (cytotoxin-associated gene A) along with induction of cancer stem-cell properties and interaction with YAP (Yes-associated protein pathway), tumor necrosis factor α-inducing protein, Lpp20 lipoprotein, Afadin protein, penicillin-binding protein 1A, microRNA-29a-3p, programmed cell death protein 4, lysosomal-associated protein transmembrane 4β, cancer-associated fibroblasts, heparin-binding epidermal growth factor (HB-EGF), matrix metalloproteinase-7 (MMP-7), and cancer stem cells (CSCs). The review summarizes the most recent findings, providing insight into potential molecular targets and new treatment strategies for gastric cancer

Ocena poziomu wiedzy osób dorosłych na temat resuscytacji krążeniowo : oddechowej (RKO) i użycia automatycznego defibrylatora zewnętrznego (AED) w miejscach publicznych

Wstęp. Wraz z rozwojem cywilizacji, wzrastającym tempem życia, rośnie liczba wypadków i chorób, zwłaszcza chorób układu krążenia. W Polsce średnia liczba zgonów około wypadkowych jest trzy razy wyższa niż średnia europejska. Wiedza na temat pierwszej pomocy jest bardzo ważna wśród społeczeństwa, które stanowi mocny filar niesienia pierwszej pomocy poszkodowanym w nagłych sytuacjach, które są stanami zagrożenia zdrowia i życia. Cel pracy. Celem pracy była ocena i porównanie wiedzy mieszkańców Kielc i Krakowa z zakresu pierwszej pomocy oraz obsługi i zastosowania Automatycznego Defibrylatora Zewnętrznego (AED). Materiał i metody. Grupę badawczą stanowiło 160 osób, z czego 80 osób było z Krakowa, w tym 45 kobiet i 35 mężczyzn i 80 osób z Kielc, w tym 45 kobiet i 35 mężczyzn. Wszyscy re-spondenci byli pełnoletni. W badaniach posłużono się metodą sondażu diagnostycznego bezpośredniego, losowego wykorzys-tując do tego celu narzędzie badawcze w postaci anonimowego kwestionariusza ankiety, opracowanego na bazie Wytycznych Resuscytacji Krążeniowo- Oddechowej 2005 (RKO). Wyniki. Mieszkańcy Krakowa wykazują lepszy poziom wiedzy, aczkolwiek znajomość i obsługa . Respondenci z Krakowa częściej i chętniej uczestniczą w szkoleniach z zakresu BLS-AED i pierwszej pomocy niż respondencki z Kielc. Wnioski. Poziom wiedzy z zakresu udzielania pierwszej pomocy, a przede wszystkim w zakresie resuscytacji krążeniowo - oddechowej i użycia AED przez społeczeństwo z Krakowa i Kielc jest niezadawalający. Istnieje pilna potrzeba wprowadzenia komplementarnego systemu nauczania zagadnień pierwszej pomocy opartego na międzynarodowych standardach, który zagwarantuje odpowiednią jakość edukacji oraz kształtowanie pozytywnych postaw niesienia pomocy, począwszy od wczesnego etapu edukacji szkolnej.Introduction: The number of accidents and diseases, especially cardio-vascular, is increasing along with the develop-ment of civilization and a growing pace of life. In Poland, the average number of accident fatalities is three times higher than the European average. The knowledge of first aid is very im-portant for society, which is a strong pillar of first aid to victims in emergency situations that are dangerous to health and life. The aim of the study: The aim of the study was to assess the knowledge of CPR and first aid in the event of sudden respiratory arrest and cardiac arrest (SCA) and the operation and use of the Automated External Defibrillator (AED). Material and methods: The study group consisted of 160 people, among whom 80 were from Kraków, including 45 women and 35 men and 80 people were from Kielce, including 45 women and 35 men. All the respondents were adults. The method of diagnostic survey was applied in the study. The research instrument was an anonymous survey questionnaire created on the basis of the Car-dio-Pulmonary Resuscitation Guidelines 2005 (CPR). Results: Residents of Kraków have better knowledge of first aid, however the knowledge and operation of the AED among both residents of Kraków and Kielce is inadequate. Respondents from Kraków more often and more willingly participate in BLS-AED and first aid training than respondents from Kielce. Conclusions: The level of knowledge of first aid and especially of Cardio-Pulmonary Resuscitation and the application of the AED is unsatisfactory among residents of Kraków and Kielce. There is an urgent need for a complementary system of first aid instruction which would be based on international standards, and which would ensure an appropriate quality of education and develop a proper attitude among people, starting with the earliest stage of school education

Noncommutative Spheres and Instantons

We report on some recent work on deformation of spaces, notably deformation of spheres, describing two classes of examples. The first class of examples consists of noncommutative manifolds associated with the so called $\theta$-deformations which were introduced out of a simple analysis in terms of cycles in the $(b,B)$-complex of cyclic homology. These examples have non-trivial global features and can be endowed with a structure of noncommutative manifolds, in terms of a spectral triple (\ca, \ch, D). In particular, noncommutative spheres $S^{N}_{\theta}$ are isospectral deformations of usual spherical geometries. For the corresponding spectral triple (\cinf(S^{N}_\theta), \ch, D), both the Hilbert space of spinors \ch= L^2(S^{N},\cs) and the Dirac operator $D$ are the usual ones on the commutative $N$-dimensional sphere $S^{N}$ and only the algebra and its action on $\ch$ are deformed. The second class of examples is made of the so called quantum spheres $S^{N}_q$ which are homogeneous spaces of quantum orthogonal and quantum unitary groups. For these spheres, there is a complete description of $K$-theory, in terms of nontrivial self-adjoint idempotents (projections) and unitaries, and of the $K$-homology, in term of nontrivial Fredholm modules, as well as of the corresponding Chern characters in cyclic homology and cohomology.Comment: Minor changes, list of references expanded and updated. These notes are based on invited lectures given at the ``International Workshop on Quantum Field Theory and Noncommutative Geometry'', November 26-30 2002, Tohoku University, Sendai, Japan. To be published in the workshop proceedings by Springer-Verlag as Lecture Notes in Physic

BRST invariant Lagrangian of spontaneously broken gauge theories in noncommutative geometry

The quantization of spontaneously broken gauge theories in noncommutative geometry(NCG) has been sought for some time, because quantization is crucial for making the NCG approach a reliable and physically acceptable theory. Lee, Hwang and Ne'eman recently succeeded in realizing the BRST quantization of gauge theories in NCG in the matrix derivative approach proposed by Coquereaux et al. The present author has proposed a characteristic formulation to reconstruct a gauge theory in NCG on the discrete space $M_4\times Z_{_N}$. Since this formulation is a generalization of the differential geometry on the ordinary manifold to that on the discrete manifold, it is more familiar than other approaches. In this paper, we show that within our formulation we can obtain the BRST invariant Lagrangian in the same way as Lee, Hwang and Ne'eman and apply it to the SU(2)$\times$U(1) gauge theory.Comment: RevTeX, page

Medical radioisotopes produced using the alpha particle beam from the Warsaw Heavy Ion Cyclotron

The internal alpha particle beam of the heavy ion cyclotron operated by the Heavy Ion Laboratory (HIL) of the University of Warsaw has a maximum energy of 32 MeV and currently an intensity of up to 1 p A. This beam is used by the HIL-University of Silesia collaboration for the production of research quantities of 211At, 72Se/72As and 43;44Sc radioisotopes. The produced activities are transported to the Institute of Nuclear Chemistry and Technology inWarsaw where research on therapeutic and imaging radiopharmaceuticals based on these radioisotopes is pursued

Noncommutative Geometry of Finite Groups

A finite set can be supplied with a group structure which can then be used to select (classes of) differential calculi on it via the notions of left-, right- and bicovariance. A corresponding framework has been developed by Woronowicz, more generally for Hopf algebras including quantum groups. A differential calculus is regarded as the most basic structure needed for the introduction of further geometric notions like linear connections and, moreover, for the formulation of field theories and dynamics on finite sets. Associated with each bicovariant first order differential calculus on a finite group is a braid operator which plays an important role for the construction of distinguished geometric structures. For a covariant calculus, there are notions of invariance for linear connections and tensors. All these concepts are explored for finite groups and illustrated with examples. Some results are formulated more generally for arbitrary associative (Hopf) algebras. In particular, the problem of extension of a connection on a bimodule (over an associative algebra) to tensor products is investigated, leading to the class of `extensible connections'. It is shown that invariance properties of an extensible connection on a bimodule over a Hopf algebra are carried over to the extension. Furthermore, an invariance property of a connection is also shared by a `dual connection' which exists on the dual bimodule (as defined in this work).Comment: 34 pages, Late