300 research outputs found
Some universal limits for nonhomogeneous birth and death processes
In this paper we consider nonhomogeneous birth and death processes (BDP) with periodic rates. Two important parameters are studied, which are helpful to describe a nonhomogeneous BDP X = X(t), tβ₯ 0: the limiting mean value (namely, the mean length of the queue at a given time t) and the double mean (i.e. the mean length of the queue for the whole duration of the BDP). We find conditions of existence of the means and determine bounds for their values, involving also the truncated BDP XN. Finally we present some examples where these bounds are used in order to approximate the double mean
Designing a Model of Professional Development of the Future Teacher-defectologist in the Context of Informatization of Education
Π ΡΡΠ°ΡΡΠ΅ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½ΠΎ ΠΎΠΏΠΈΡΠ°Π½ΠΈΠ΅ Π°Π²ΡΠΎΡΡΠΊΠΎΠΉ ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠ³ΠΎ ΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½ΠΈΡ Π±ΡΠ΄ΡΡΠ΅Π³ΠΎ ΠΏΠ΅Π΄Π°Π³ΠΎΠ³Π°-Π΄Π΅ΡΠ΅ΠΊΡΠΎΠ»ΠΎΠ³Π° Π² ΡΡΠ»ΠΎΠ²ΠΈΡΡ
ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠ·Π°ΡΠΈΠΈ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°Π½ΠΈΡ, ΠΊΠΎΡΠΎΡΠ°Ρ ΠΎΠΏΡΠ΅Π΄Π΅Π»ΡΠ΅Ρ ΠΎΡΠΈΠ΅Π½ΡΠΈΡΡ Π΅Π³ΠΎ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎ-Π»ΠΈΡΠ½ΠΎΡΡΠ½ΠΎΠ³ΠΎ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π½Π° ΡΡΠ°ΠΏΠ΅ ΠΎΠ±ΡΡΠ΅Π½ΠΈΡ Π² Π²ΡΠ·Π΅.The article presents a de-scription of the model of professional development of the future teacher-defectologist under the conditions of informatization of education, which determines the guidelines for their professional and personal development at the stage of university education
Bridging The Gap Between Academia and Practice: A case study for collaborative digital design to fabrication workflow for interlocking kit-of-parts
The implementation of digital design workflows is an opportunity to facilitate the knowledge exchange between the industry and research, required in the face of the climate emergency. This paper presents outcomes of a series of digital design to fabrication workshops, resulting in three-party collaboration between an international architectural design firm, a university, and a global food producer. The paper presents an initial step towards an integrated material system based on an abundantly available industrial by-product of sugar manufacturing. The idea of topological interlocking has been used as a concept to define components-based system for the novel material, tested in a scaled prototype with university students
Environmental monitoring of natural waters in Krasnodar and Stavropol Territories
The environmental monitoring of natural waters in Krasnodar (Uspensky and Novokubansky districts) and Stavropol (Kochubeyevsky District) Territories was conducted. In the course of study, various elements and compounds harmful to animals and humans, which exceed maximum permissible concentrations, were identified
ΠΠ°ΡΡΡΠ΅Π½ΠΈΡ Π² ΡΠΈΡΡΠ΅ΠΌΠ΅ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ° ΠΏΠΎΡΠ»Π΅ ΠΏΠ΅ΡΠ΅Π½Π΅ΡΠ΅Π½Π½ΠΎΠΉ Π½ΠΎΠ²ΠΎΠΉ ΠΊΠΎΡΠΎΠ½Π°Π²ΠΈΡΡΡΠ½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ COVID-19
During the pandemic, a large number of works devoted to COVID infection have appeared, which have made it possible to understand the pathogenetic features of the disease and to accumulate significant clinical experience. However, the question remains about the degree of participation of humoral and cellular (primarily T-cell) immunity in the mechanisms of immune defense and resistance to COVID-19, the individual features of the immune response in different subjects. Post-COVID syndrome is currently a separate diagnosis included in the ICD-10 International Classification of Diseases, but the long-term effects of the SARS-CoV-2 on the immune system are not yet well established. At the same time, a long-term increased activity of the immune system can contribute to the development of autoimmune reactions. The review of the literature presents the results of studies, mainly devoted to immune system disorders after COVID infection. The changes in subpopulations of T-lymphocytes, B-lymphocytes, their functional properties, the complement system and other factors of humoral immunity, as well as the production of a number of cytokines are described. Data on immune disorders in post-COVID syndrome and during the convalescence period are presented in detail. Since COVID-19 is an infection that has a significant impact on the hematopoietic system and hemostasis, special attention is paid to the category of subjects with an increased risk of severe complications. Among the latter are elderly patients, persons suffering from diabetes mellitus, oncological and oncohematological patients, in particular, with hematopoietic and lymphoid tissue neoplasia, such as chronic lymphocytic leukemia, lymphoma, multiple myeloma. The review pays special attention to the peculiarities of the course of COVID-19 and the response of the immune system to vaccination in patients with oncohematological diseases. Deciphering the significance of individual links of cellular and humoral immunity in patients who have undergone COVID-19 is an important issue in creating effective vaccines and improving therapeutic methods.ΠΠ° Π²ΡΠ΅ΠΌΡ ΠΏΠ°Π½Π΄Π΅ΠΌΠΈΠΈ ΠΏΠΎΡΠ²ΠΈΠ»ΠΎΡΡ Π±ΠΎΠ»ΡΡΠΎΠ΅ ΡΠΈΡΠ»ΠΎ ΡΠ°Π±ΠΎΡ, ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π½ΡΡ
COVID-ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ, ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ²ΡΠΈΡ
Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ Π³Π»ΡΠ±ΠΎΠΊΠΎ ΠΏΠΎΠ½ΡΡΡ ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅ΡΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΡΠ΅ΡΠ΅Π½ΠΈΡ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡ, Π½Π°ΠΊΠΎΠΏΠΈΡΡ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΡΠΉ ΠΊΠ»ΠΈΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΉ ΠΎΠΏΡΡ. ΠΠ΄Π½Π°ΠΊΠΎ ΠΎΡΡΠ°ΡΡΡΡ ΠΎΡΠΊΡΡΡΡΠΌ Π²ΠΎΠΏΡΠΎΡ ΠΎ ΡΡΠ΅ΠΏΠ΅Π½ΠΈ ΡΡΠ°ΡΡΠΈΡ Π³ΡΠΌΠΎΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈ ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ (ΠΏΡΠ΅ΠΆΠ΄Π΅ Π²ΡΠ΅Π³ΠΎ, Π’-ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ Π·Π²Π΅Π½Π°) ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ° Π² ΠΌΠ΅Ρ
Π°Π½ΠΈΠ·ΠΌΠ°Ρ
ΠΈΠΌΠΌΡΠ½Π½ΠΎΠΉ Π·Π°ΡΠΈΡΡ ΠΈ Π½Π΅Π²ΠΎΡΠΏΡΠΈΠΈΠΌΡΠΈΠ²ΠΎΡΡΠΈ ΠΊ ΠΈΠ½ΡΠΈΡΠΈΡΠΎΠ²Π°Π½ΠΈΡ Π²ΠΈΡΡΡΠΎΠΌ, ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΡΡ
ΠΈΠΌΠΌΡΠ½Π½ΠΎΠ³ΠΎ ΠΎΡΠ²Π΅ΡΠ° ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΡ
Π»ΠΈΡ. ΠΠΎΡΡΠΊΠΎΠ²ΠΈΠ΄Π½ΡΠΉ ΡΠΈΠ½Π΄ΡΠΎΠΌ Π² Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠ°ΠΌΠΎΡΡΠΎΡΡΠ΅Π»ΡΠ½ΡΠΌ Π΄ΠΈΠ°Π³Π½ΠΎΠ·ΠΎΠΌ ΠΈ Π²ΠΊΠ»ΡΡΠ΅Π½ Π² ΠΠ΅ΠΆΠ΄ΡΠ½Π°ΡΠΎΠ΄Π½ΡΡ ΠΊΠ»Π°ΡΡΠΈΡΠΈΠΊΠ°ΡΠΈΡ Π±ΠΎΠ»Π΅Π·Π½Π΅ΠΉ ΠΠΠ-10, Π½ΠΎ ΠΎΡΠ΄Π°Π»Π΅Π½Π½ΡΠ΅ ΠΏΠΎΡΠ»Π΅Π΄ΡΡΠ²ΠΈΡ Π²ΠΎΠ·Π΄Π΅ΠΉΡΡΠ²ΠΈΡ Π²ΠΈΡΡΡΠ° SARS-CoV-2 Π½Π° ΠΈΠΌΠΌΡΠ½Π½ΡΡ ΡΠΈΡΡΠ΅ΠΌΡ Π΅ΡΠ΅ Π½Π΅Π΄ΠΎΡΡΠ°ΡΠΎΡΠ½ΠΎ Ρ
ΠΎΡΠΎΡΠΎ ΡΡΡΠ°Π½ΠΎΠ²Π»Π΅Π½Ρ. ΠΡΠΈ ΡΡΠΎΠΌ Π΄Π»ΠΈΡΠ΅Π»ΡΠ½ΠΎ ΠΏΠΎΠ΄Π΄Π΅ΡΠΆΠΈΠ²Π°Π΅ΠΌΠ°Ρ ΠΏΠΎΠ²ΡΡΠ΅Π½Π½Π°Ρ Π°ΠΊΡΠΈΠ²Π½ΠΎΡΡΡ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ ΠΌΠΎΠΆΠ΅Ρ ΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΠΎΠ²Π°ΡΡ ΡΠ°Π·Π²ΠΈΡΠΈΡ Π°ΡΡΠΎΠΈΠΌΠΌΡΠ½Π½ΡΡ
ΡΠ΅Π°ΠΊΡΠΈΠΉ ΠΈ ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ. Π ΠΎΠ±Π·ΠΎΡΠ΅ Π»ΠΈΡΠ΅ΡΠ°ΡΡΡΡ ΠΏΡΠΈΠ²ΠΎΠ΄ΡΡΡΡ ΡΠ΅Π·ΡΠ»ΡΡΠ°ΡΡ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΠΉ, Π³Π»Π°Π²Π½ΡΠΌ ΠΎΠ±ΡΠ°Π·ΠΎΠΌ, ΠΏΠΎΡΠ²ΡΡΠ΅Π½Π½ΡΡ
ΠΏΡΠΎΠ±Π»Π΅ΠΌΠ°ΠΌ Π½Π°ΡΡΡΠ΅Π½ΠΈΠΉ Π² ΡΠΈΡΡΠ΅ΠΌΠ΅ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ° ΠΏΠΎΡΠ»Π΅ ΠΏΠ΅ΡΠ΅Π½Π΅ΡΠ΅Π½Π½ΠΎΠΉ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠΈ COVID. ΠΠΏΠΈΡΠ°Π½Ρ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ Π² ΡΡΠ±ΠΏΠΎΠΏΡΠ»ΡΡΠΈΡΡ
Π’-Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ², Π-Π»ΠΈΠΌΡΠΎΡΠΈΡΠΎΠ², ΠΈΡ
ΡΡΠ½ΠΊΡΠΈΠΎΠ½Π°Π»ΡΠ½ΡΡ
ΡΠ²ΠΎΠΉΡΡΠ², ΡΠΈΡΡΠ΅ΠΌΡ ΠΊΠΎΠΌΠΏΠ»Π΅ΠΌΠ΅Π½ΡΠ° ΠΈ Π΄ΡΡΠ³ΠΈΡ
ΡΠ°ΠΊΡΠΎΡΠΎΠ² Π³ΡΠΌΠΎΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ°, Π° ΡΠ°ΠΊΠΆΠ΅ ΠΏΡΠΎΠ΄ΡΠΊΡΠΈΠΈ ΡΡΠ΄Π° ΠΊΠ»ΡΡΠ΅Π²ΡΡ
ΡΠΈΡΠΎΠΊΠΈΠ½ΠΎΠ². ΠΠΎΠ΄ΡΠΎΠ±Π½ΠΎ ΠΏΡΠ΅Π΄ΡΡΠ°Π²Π»Π΅Π½Ρ Π΄Π°Π½Π½ΡΠ΅ ΠΎΠ± ΠΈΠΌΠΌΡΠ½ΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΡ
Π½Π°ΡΡΡΠ΅Π½ΠΈΡΡ
ΠΏΡΠΈ ΠΏΠΎΡΡΠΊΠΎΠ²ΠΈΠ΄Π½ΠΎΠΌ ΡΠΈΠ½Π΄ΡΠΎΠΌΠ΅ ΠΈ Π² ΠΏΠ΅ΡΠΈΠΎΠ΄Π΅ ΡΠ΅ΠΊΠΎΠ½Π²Π°Π»Π΅ΡΡΠ΅Π½ΡΠΈΠΈ. Π’Π°ΠΊ ΠΊΠ°ΠΊ COVID-19 ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΈΠ½ΡΠ΅ΠΊΡΠΈΠ΅ΠΉ, ΠΎΠΊΠ°Π·ΡΠ²Π°ΡΡΠ΅ΠΉ Π·Π½Π°ΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠ΅ Π²Π»ΠΈΡΠ½ΠΈΠ΅ Π½Π° ΠΊΡΠΎΠ²Π΅ΡΠ²ΠΎΡΠ½ΡΡ ΡΠΈΡΡΠ΅ΠΌΡ ΠΈ Π³Π΅ΠΌΠΎΡΡΠ°Π·, ΡΠΎ ΠΎΡΠΎΠ±ΠΎΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΡΠ΄Π΅Π»ΡΠ΅ΡΡΡ ΠΊΠ°ΡΠ΅Π³ΠΎΡΠΈΠΈ Π»ΠΈΡ Ρ ΠΏΠΎΠ²ΡΡΠ΅Π½Π½ΡΠΌ ΡΠΈΡΠΊΠΎΠΌ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΡΠΆΠ΅Π»ΡΡ
ΠΎΡΠ»ΠΎΠΆΠ½Π΅Π½ΠΈΠΉ. Π ΡΠΈΡΠ»Π΅ ΠΏΠΎΡΠ»Π΅Π΄Π½ΠΈΡ
β ΠΏΠΎΠΆΠΈΠ»ΡΠ΅ Π±ΠΎΠ»ΡΠ½ΡΠ΅, ΠΏΠ°ΡΠΈΠ΅Π½ΡΡ, ΡΡΡΠ°Π΄Π°ΡΡΠΈΠ΅ ΡΠ°Ρ
Π°ΡΠ½ΡΠΌ Π΄ΠΈΠ°Π±Π΅ΡΠΎΠΌ, ΠΎΠ½ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ ΠΈ ΠΎΠ½ΠΊΠΎΠ³Π΅ΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ, Π² ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΠΈ ΠΎΠΏΡΡ
ΠΎΠ»Π΅Π²ΡΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ ΠΊΡΠΎΠ²Π΅ΡΠ²ΠΎΡΠ½ΠΎΠΉ ΠΈ Π»ΠΈΠΌΡΠΎΠΈΠ΄Π½ΠΎΠΉ ΡΠΊΠ°Π½Π΅ΠΉ, ΡΠ°ΠΊΠΈΠΌΠΈ ΠΊΠ°ΠΊ Ρ
ΡΠΎΠ½ΠΈΡΠ΅ΡΠΊΠΈΠΉ Π»ΠΈΠΌΡΠΎΠ»Π΅ΠΉΠΊΠΎΠ·, Π»ΠΈΠΌΡΠΎΠΌΠ°, ΠΌΠ½ΠΎΠΆΠ΅ΡΡΠ²Π΅Π½Π½Π°Ρ ΠΌΠΈΠ΅Π»ΠΎΠΌΠ°. Π ΠΎΠ±Π·ΠΎΡΠ΅ ΡΠ΄Π΅Π»Π΅Π½ΠΎ ΠΎΡΠ΄Π΅Π»ΡΠ½ΠΎΠ΅ Π²Π½ΠΈΠΌΠ°Π½ΠΈΠ΅ ΠΎΡΠΎΠ±Π΅Π½Π½ΠΎΡΡΡΠΌ ΡΠ΅ΡΠ΅Π½ΠΈΡ COVID-19 ΠΈ ΡΠ΅Π°ΠΊΡΠΈΠΈ ΠΈΠΌΠΌΡΠ½Π½ΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ Π½Π° Π²Π°ΠΊΡΠΈΠ½Π°ΡΠΈΡ Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ² Ρ ΠΎΠ½ΠΊΠΎΠ³Π΅ΠΌΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠΌΠΈ Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΡΠΌΠΈ. Π Π°ΡΡΠΈΡΡΠΎΠ²ΠΊΠ° Π·Π½Π°ΡΠΈΠΌΠΎΡΡΠΈ ΠΎΡΠ΄Π΅Π»ΡΠ½ΡΡ
Π·Π²Π΅Π½ΡΠ΅Π² ΠΊΠ»Π΅ΡΠΎΡΠ½ΠΎΠ³ΠΎ ΠΈ Π³ΡΠΌΠΎΡΠ°Π»ΡΠ½ΠΎΠ³ΠΎ ΠΈΠΌΠΌΡΠ½ΠΈΡΠ΅ΡΠ° Ρ ΠΏΠ°ΡΠΈΠ΅Π½ΡΠΎΠ², ΠΏΠ΅ΡΠ΅Π½Π΅ΡΡΠΈΡ
COVID-19, ΡΠ²Π»ΡΠ΅ΡΡΡ Π²Π°ΠΆΠ½ΡΠΌ Π²ΠΎΠΏΡΠΎΡΠΎΠΌ ΠΏΡΠΈ ΡΠΎΠ·Π΄Π°Π½ΠΈΠΈ ΡΡΡΠ΅ΠΊΡΠΈΠ²Π½ΡΡ
Π²Π°ΠΊΡΠΈΠ½ ΠΈ ΡΠΎΠ²Π΅ΡΡΠ΅Π½ΡΡΠ²ΠΎΠ²Π°Π½ΠΈΠΈ ΠΌΠ΅ΡΠΎΠ΄ΠΎΠ² ΡΠ΅ΡΠ°ΠΏΠΈΠΈ
Information-educational environment of a university as a resource for professional training of a teacher-defectologist
Π ΡΡΠ°ΡΡΠ΅ ΡΠ°ΡΡΠΌΠ°ΡΡΠΈΠ²Π°ΡΡΡΡ ΡΠ΅ΡΡΡΡΡ ΠΈ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΈΠ½ΡΠΎΡΠΌΠ°ΡΠΈΠΎΠ½Π½ΠΎΠΉ ΠΎΠ±ΡΠ°Π·ΠΎΠ²Π°ΡΠ΅Π»ΡΠ½ΠΎΠΉ ΡΡΠ΅Π΄Ρ Π² ΠΏΡΠΎΡΠ΅ΡΡΠ΅ ΠΏΡΠΎΡΠ΅ΡΡΠΈΠΎΠ½Π°Π»ΡΠ½ΠΎΠΉ ΠΏΠΎΠ΄Π³ΠΎΡΠΎΠ²ΠΊΠΈ ΠΏΠ΅Π΄Π°Π³ΠΎΠ³Π°-Π΄Π΅ΡΠ΅ΠΊΡΠΎΠ»ΠΎΠ³Π°.The purpose of the research was to study the resources and opportunities of the digital educational environment in the process of professional training of a teacher-defectologist
Clinical and morphological features of salmonellosis in cows and calves affected by heat stress
Exposure to abnormally high temperatures in the Middle Urals has ledtochronic heat stress in cattle. Despitethe measures taken toprotect thedairy herdfrom overheating (fans, irrigationwith coolwater, livestocksunshades), the heatstressunderminedtheimmunityofanimals, thus, leadingtoan excessiverisein Salmonella population in the gastrointestinal tract, increasedin test in alpermeability, and could also bethecause of increasedvirulence of such serotypes asΒ β Salmonella choleraesuis, that are not typical for cattle. The simultaneous presenceof twopathogensof Salmonella entericasubsp. entericaspecies: i.e.Β Salmonella enteritidis and Salmonella choleraesuisΒ β causeda number of clinical and morphological changesin adultcows. In cows, the infection manifested itself by persistent diarrhea with mucus, reduced milkproduction and intoxication. In calves, the disease was accompanied by septic signs, severein toxication, hyperthermia (40.5β41.0Β Β°C), severed ehydration (morethan 7%) and death. Histopathological examination of bovineparenchymal organs revealed changes typical for salmonellos is pathological process: specific salmonella granulomas were foundin parenchymalorgans (liver, spleen). Some pathological processestypical for sepsiswere foundin other parenchymalorgans (kidneys, heart). The nature of pathological changes in dicates that there is as epticprocess that spreads both hematogenically and lymphogenically, and the structure of granulomas most likely indicates that such apathogen as Salmonelacholeraesuis circulates in cattle
Impact of transfusion of blood components on the recipient immune system
Transfusions of blood provide essential therapeutic measures in a number of pathological conditions. However, when carrying out blood component therapy, it is important to consider probability of post-transfusion complications. Most of them are immune-mediated side effects. The unfavorable consequences of blood transfusions can manifest at long-range time periods, and pathogenesis of these phenomena may be associated not only with the presence of alloantibodies. They may be caused by alloimmunization to HLA antigens, leukocyte factors, including cytokines, products of leukocyte degranulation, as well as storage-related erythrocyte damage (Β«storage lesionΒ»), immunomodulatory properties of extracellular vesicles or microparticles derived from blood components, and other factors. Despite significant number of publications on this issue, a lot of unresolved issues still remain, concerning transfusion-related effects of blood components on the immune system of recipients. The review article provides the results of current studies in this area. We present and discuss the results of current studies and the features of transfusion-mediated immunomodulation (TRIM) revealed over recent years, when transfusing different blood components. The role of plasma factors, microparticles, platelets and erythrocytes, HLA sensitization and microchimerism in the development of TRIM is highlighted, the data on occurrence and clinical features of TRIM in perioperative period are presented. A separate section of the review provides information about recent clinical studies, devoted to the issues of TRIM in different clinical cohorts, including newborns, patients with malignant neoplasms, immunocompromised patients after heart and vascular surgery. The data on TRIM incidence in the patients with exhausted immune system due to previous disease or treatment, severe comorbidity, extensive surgical thoracic/abdominal intervention and artificial circulation are also in scope. As based on the studies performed, the role of distinct measures, e.g., washing of erythrocyte concentrates, leukodepletion, and gamma irradiation are discussed in view of potential TRIM prevention. The results of published research do not allow us to draw definite conclusions about the effects of blood component transfusion on the immune system of recipients with respect to differences between the studied groups of patients, characteristics of the studied disorders and clinical situations, diversity of hemocomponents, as well as varying standards of transfusion therapy adopted in different countries. However, the systematic literature review may provide some guidance in transfusion-mediated immune modulation
The cellular location of proteolytic enzymes of Bacillus intermedius
The activities of proteinases in the culture fluid and cellular fractions of Bacillus intermedius 3-19 grown under various conditions were studied. Thiol-dependent serine proteinase was the prevalent enzyme in the total pool of extracellular proteinases (70%); its catalytically active form was also detected in the cell membrane and, during active enzyme production, in the cell wall. Another enzyme, glutamyl endopeptidase (10% of the total pool), was detected in the cell membrane; it was also found in the cell wall and cytoplasm during active enzyme secretion into the growth medium. The production of these enzymes was maximal on medium containing inorganic phosphate and gelatin and decreased 2- to 4-fold on medium with glucose and lactate. The level of activity of extracellular enzymes correlated with that of corresponding membrane-bound proteins. The addition of CoCl2 (2 mM) into the medium caused an essential increase in extracellular glutamyl endopeptidase activity and promoted the release of the membrane-bound enzyme into the culture fluid. Proteolytic activity towards casein was also detected in the cytoplasm. The proteinases localized in the cytoplasm were shown to differ in their properties from those secreted. Β© 2000 MAIK "Nauka/Interperiodica"
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