80 research outputs found
Decay of Quantum Accelerator Modes
Experimentally observable Quantum Accelerator Modes are used as a test case
for the study of some general aspects of quantum decay from classical stable
islands immersed in a chaotic sea. The modes are shown to correspond to
metastable states, analogous to the Wannier-Stark resonances. Different regimes
of tunneling, marked by different quantitative dependence of the lifetimes on
1/hbar, are identified, depending on the resolution of KAM substructures that
is achieved on the scale of hbar. The theory of Resonance Assisted Tunneling
introduced by Brodier, Schlagheck, and Ullmo [9], is revisited, and found to
well describe decay whenever applicable.Comment: 16 pages, 11 encapsulated postscript figures (figures with a better
resolution are available upon request to the authors); added reference for
section
Classes of fast and specific search mechanisms for proteins on DNA
Problems of search and recognition appear over different scales in biological
systems. In this review we focus on the challenges posed by interactions
between proteins, in particular transcription factors, and DNA and possible
mechanisms which allow for a fast and selective target location. Initially we
argue that DNA-binding proteins can be classified, broadly, into three distinct
classes which we illustrate using experimental data. Each class calls for a
different search process and we discuss the possible application of different
search mechanisms proposed over the years to each class. The main thrust of
this review is a new mechanism which is based on barrier discrimination. We
introduce the model and analyze in detail its consequences. It is shown that
this mechanism applies to all classes of transcription factors and can lead to
a fast and specific search. Moreover, it is shown that the mechanism has
interesting transient features which allow for stability at the target despite
rapid binding and unbinding of the transcription factor from the target.Comment: 65 pages, 23 figure
Classical R-Matrices and the Feigin-Odesskii Algebra via Hamiltonian and Poisson Reductions
We present a formula for a classical -matrix of an integrable system
obtained by Hamiltonian reduction of some free field theories using pure gauge
symmetries. The framework of the reduction is restricted only by the assumption
that the respective gauge transformations are Lie group ones. Our formula is in
terms of Dirac brackets, and some new observations on these brackets are made.
We apply our method to derive a classical -matrix for the elliptic
Calogero-Moser system with spin starting from the Higgs bundle over an elliptic
curve with marked points. In the paper we also derive a classical
Feigin-Odesskii algebra by a Poisson reduction of some modification of the
Higgs bundle over an elliptic curve. This allows us to include integrable
lattice models in a Hitchin type construction.Comment: 27 pages LaTe
Molecular motors robustly drive active gels to a critically connected state
Living systems often exhibit internal driving: active, molecular processes
drive nonequilibrium phenomena such as metabolism or migration. Active gels
constitute a fascinating class of internally driven matter, where molecular
motors exert localized stresses inside polymer networks. There is evidence that
network crosslinking is required to allow motors to induce macroscopic
contraction. Yet a quantitative understanding of how network connectivity
enables contraction is lacking. Here we show experimentally that myosin motors
contract crosslinked actin polymer networks to clusters with a scale-free size
distribution. This critical behavior occurs over an unexpectedly broad range of
crosslink concentrations. To understand this robustness, we develop a
quantitative model of contractile networks that takes into account network
restructuring: motors reduce connectivity by forcing crosslinks to unbind.
Paradoxically, to coordinate global contractions, motor activity should be low.
Otherwise, motors drive initially well-connected networks to a critical state
where ruptures form across the entire network.Comment: Main text: 21 pages, 5 figures. Supplementary Information: 13 pages,
8 figure
Strain-controlled criticality governs the nonlinear mechanics of fibre networks
Disordered fibrous networks are ubiquitous in nature as major structural
components of living cells and tissues. The mechanical stability of networks
generally depends on the degree of connectivity: only when the average number
of connections between nodes exceeds the isostatic threshold are networks
stable (Maxwell, J. C., Philosophical Magazine 27, 294 (1864)). Upon increasing
the connectivity through this point, such networks undergo a mechanical phase
transition from a floppy to a rigid phase. However, even sub-isostatic networks
become rigid when subjected to sufficiently large deformations. To study this
strain-controlled transition, we perform a combination of computational
modeling of fibre networks and experiments on networks of type I collagen
fibers, which are crucial for the integrity of biological tissues. We show
theoretically that the development of rigidity is characterized by a
strain-controlled continuous phase transition with signatures of criticality.
Our experiments demonstrate mechanical properties consistent with our model,
including the predicted critical exponents. We show that the nonlinear
mechanics of collagen networks can be quantitatively captured by the
predictions of scaling theory for the strain-controlled critical behavior over
a wide range of network concentrations and strains up to failure of the
material
Arnol'd Tongues and Quantum Accelerator Modes
The stable periodic orbits of an area-preserving map on the 2-torus, which is
formally a variant of the Standard Map, have been shown to explain the quantum
accelerator modes that were discovered in experiments with laser-cooled atoms.
We show that their parametric dependence exhibits Arnol'd-like tongues and
perform a perturbative analysis of such structures. We thus explain the
arithmetical organisation of the accelerator modes and discuss experimental
implications thereof.Comment: 20 pages, 6 encapsulated postscript figure
Optimal diffusive search:nonequilibrium resetting versus equilibrium dynamics
We study first-passage time problems for a diffusive particle with stochastic
resetting with a finite rate . The optimal search time is compared
quantitatively with that of an effective equilibrium Langevin process with the
same stationary distribution. It is shown that the intermittent, nonequilibrium
strategy with non-vanishing resetting rate is more efficient than the
equilibrium dynamics. Our results are extended to multiparticle systems where a
team of independent searchers, initially uniformly distributed with a given
density, looks for a single immobile target. Both the average and the typical
survival probability of the target are smaller in the case of nonequilibrium
dynamics.Comment: 15 pages, 2 figures, submitted to Journal of Physics A: Mathematical
and Theoretica
Search reliability and search efficiency of combined LĂ©vyâBrownian motion: long relocations mingled with thorough local exploration
A combined dynamics consisting of Brownian motion and Levy flights is exhibited by a variety of biological systems performing search processes. Assessing the search reliability of ever locating the target and the search efficiency of doing so economically of such dynamics thus poses an important problem. Here we model this dynamics by a one-dimensional fractional Fokker-Planck equation combining unbiased Brownian motion and Levy flights. By solving this equation both analytically and numerically we show that the superposition of recurrent Brownian motion and Levy flights with stable exponent α<1, by itself implying zero probability of hitting a point on a line, lead to transient motion with finite probability of hitting any point on the line. We present results for the exact dependence of the values of both the search reliability and the search efficiency on the distance between the starting and target positions as well as the choice of the scaling exponent α of the Levy flight component
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