The effects of education on homophobic attitudes in college students

The purpose of this study was to investigate whether attitudes towards homosexuals could be modified by education from a biological or moral/religious perspective. Sixty-eight male and fifty-seven female volunteers from a mid-sized Catholic liberal arts university were randomly assigned to two groups. The first group viewed a video discussing homosexuality from a biological perspective. The second group viewed a video discussing homosexuality from a moral/religious perspective. The subject\u27s attitudes towards homosexuality were measured with a modified version of Smith\u27s Homophobic Scale (Lumby, 1976) immediately after viewing the video. A two-way (video x gender) ANOVA revealed significant main effects of video for three items on the questionnaire. Subjects viewing the biological video were less likely to be homophobic than subjects viewing the moral religious video on one of the questions. Significant main effects for gender revealed that males were more likely than females to be homophobic on most of the items

Analysis of a bridge failure due to fire using computational fluid dynamics and finite element models

Bridge fires are a major concern because of the consequences that these kind of events have and because they are a real threat. However, bridge fire response is under researched and not covered in the codes. This paper studies the capabilities of numerical models to predict the fire response of a bridge and provides modeling guidelines useful for improving bridge design. To reach this goal, a numerical analysis of the fire of the I-65 overpass in Birmingham, Alabama, USA in 2002 is carried out. The analyses are based on computational fluid dynamics (CFD) for creating the fire model, and finite element (FE) software for obtaining the thermo-mechanical response of the bridge. The models are validated with parametric studies that consider heat release rate of the spilled fuel, discretization of the fire temperature in the transition from CFD to FE modeling, and boundary conditions. The validated model is used in a study to evaluate the influence of fire scenario (CFD versus standard fires), and live load. Results show that numerical models are able to simulate the response of the bridge and can be used as a basis for a performance-based approach for the design of bridges under fire. Additionally, it is found that applying the Eurocode standard and hydrocarbon fires along the full length of the bridge does not adequately represent a real bridge fire response for medium-long span bridges such as this case study. The study also shows that live loads essentially do not influence the response of the bridge. (C) 2014 Elsevier Ltd. All rights reserved.Funding for this research has been provided by the Spanish Ministry of Science and Innovation (research project BIA 2011-27104) and the Universitat Politecnica de Valencia (Research and Development Support Program PAID-06-11). Funding has also been provided to Dr. Maria Garlock by the National Science Foundation (NSF) under award number CMMI-1068252. The authors are grateful to R. King from the Federal Highway Administration of the USA, J. Black and T. Colquett from the Alabama Department of Transportation, J. Glassman from Princeton University, J.V. Aguado from Ecole Centrale de Nantes and to J. Hidalgo from the University of Edinburgh for all the information and support provided. All opinions expressed in this paper are the authors' and do not necessarily reflect the policies and views of the sponsors.Alós Moya, J.; Paya-Zaforteza, I.; Garlock, ME.; Loma-Ossorio, E.; Schiffner, D.; Hospitaler Pérez, A. (2014). Analysis of a bridge failure due to fire using computational fluid dynamics and finite element models. Engineering Structures. 68:96-110. https://doi.org/10.1016/j.engstruct.2014.02.022S961106

Anonymity and Rewards in Peer Rating Systems

When peers rate each other, they may choose to rate inaccurately in order to boost their own reputation or unfairly lower another’s. This could be successfully mitigated by having a reputation server incentivise accurate ratings with a reward. However, assigning rewards becomes a challenge when ratings are anonymous, since the reputation server cannot tell which peers to reward for rating accurately. To address this, we propose an anonymous peer rating system in which users can be rewarded for accurate ratings, and we formally define its model and security requirements. In our system ratings are rewarded in batches, so that users claiming their rewards only reveal they authored one in this batch of ratings. To ensure the anonymity set of rewarded users is not reduced, we also split the reputation server into two entities, the Rewarder, who knows which ratings are rewarded, and the Reputation Holder, who knows which users were rewarded. We give a provably secure construction satisfying all the security properties required. For our construction we use a modification of a Direct Anonymous Attestation scheme to ensure that peers can prove their own reputation when rating others, and that multiple feedback on the same subject can be detected. We then use Linkable Ring Signatures to enable peers to be rewarded for their accurate ratings, while still ensuring that ratings are anonymous. Our work results in a system which allows for accurate ratings to be rewarded, whilst still providing anonymity of ratings with respect to the central entities managing the system

CIS-based registration of quality of life in a single source approach

Background: Documenting quality of life (QoL) in routine medical care and using it both for treatment and for clinical research is not common, although such information is absolutely valuable for physicians and patients alike. We therefore aimed at developing an efficient method to integrate quality of life information into the clinical information system (CIS) and thus make it available for clinical care and secondary use. Methods: We piloted our method in three different medical departments, using five different QoL questionnaires. In this setting we used structured interviews and onsite observations to perform workflow and form analyses. The forms and pertinent data reports were implemented using the integrated tools of the local CIS. A web-based application for mobile devices was developed based on XML schemata to facilitate data import into the CIS. Data exports of the CIS were analysed with statistical software to perform an analysis of data quality. Results: The quality of life questionnaires are now regularly documented by patients and physicians. The resulting data is available in the Electronic Health Record (EHR) and can be used for treatment purposes and communication as well as research functionalities. The completion of questionnaires by the patients themselves using a mobile device (iPad) and the import of the respective data into the CIS forms were successfully tested in a pilot installation. The quality of data is rendered high by the use of automatic score calculations as well as the automatic creation of forms for follow-up documentation. The QoL data was exported to research databases for use in scientific analysis. Conclusion: The CIS-based QoL is technically feasible, clinically accepted and provides an excellent quality of data for medical treatment and clinical research. Our approach with a commercial CIS and the web-based application is transferable to other sites

How valid are current diagnostic criteria for dental erosion?

In principle, there is agreement about the clinical diagnostic criteria for dental erosion, basically defined as cupping and grooving of the occlusal/incisal surfaces, shallow defects on smooth surfaces located coronal from the enamel–cementum junction with an intact cervical enamel rim and restorations rising above the adjacent tooth surface. This lesion characteristic was established from clinical experience and from observations in a small group of subjects with known exposure to acids rather than from systematic research. Their prevalence is higher in risk groups for dental erosion compared to subjects not particularly exposed to acids, but analytical epidemiological studies on random or cluster samples often fail to find a relation between occurrence or severity of lesions and any aetiological factor. Besides other aspects, this finding might be due to lack of validity with respect to diagnostic criteria. In particular, cupping and grooving might be an effect of abrasion as well as of erosion and their value for the specific diagnosis of erosion must be doubted. Knowledge about the validity of current diagnostic criteria of different forms of tooth wear is incomplete, therefore further research is needed

Large-scale, prospective, observational studies in patients with psoriasis and psoriatic arthritis: A systematic and critical review

<p>Abstract</p> <p>Background</p> <p>Observational studies, if conducted appropriately, play an important role in the decision-making process providing invaluable information on effectiveness, patient-reported outcomes and costs in a real-world environment. We conducted a systematic review of large-scale, prospective, cohort studies with the aim of (a) summarising design characteristics, the interventions or aspects of the disease studied and the outcomes measured and (b) investigating methodological quality.</p> <p>Methods</p> <p>We included prospective, cohort studies which included at least 100 adults with psoriasis or psoriatic arthritis. Studies were identified through searches in electronic databases (Pubmed, Medline, Cochrane library, Centre for Reviews and Dissemination). Information on study characteristics were extracted and tabulated and quality assessment, using a checklist of 18 questions, was conducted.</p> <p>Results</p> <p>Thirty five papers covering 16 cohorts met the inclusion criteria. There were ten treatment-related studies, only two of which provided a comparison between treatments, and six non-treatment studies which examined a number of characteristics of the disease including mortality, morbidity, cost of illness and health-related quality of life. All studies included a clinical outcome measure and 11 included patient-reported outcomes, however only two studies reported information on patient utilities and two on costs. The quality of the assessed studies varied widely. Studies did well on a number of quality assessment questions including having clear objectives, documenting selection criteria, providing a representative sample, defining interventions/characteristics under study, defining and using appropriate outcomes, describing results clearly and using appropriate statistical tests. The quality assessment criteria least adhered to involved questions regarding sample size calculations, describing potential selection bias, defining and adjusting for confounders and losses to follow-up, and defining and describing a comparison group.</p> <p>Conclusion</p> <p>The review highlights the need for well designed prospective observational studies on the effectiveness, patient-reported outcomes and economic impact of treatment regimes for patients with psoriasis and psoriatic arthritis in a real-world environment.</p

HIV-1 superinfection results in broad polyclonal neutralizing antibodies

<div><p>HIV-1 vaccines designed to date have failed to elicit neutralizing antibodies (Nabs) that are capable of protecting against globally diverse HIV-1 subtypes. One relevant setting to study the development of a strong, cross-reactive Nab response is HIV-1 superinfection (SI), defined as sequential infections from different source partners. SI has previously been shown to lead to a broader and more potent Nab response when compared to single infection, but it is unclear whether SI also impacts epitope specificity and if the epitopes targeted after SI differ from those targeted after single infection. Here the post-SI Nab responses were examined from 21 Kenyan women collectively exposed to subtypes A, C, and D and superinfected after a median time of ~1.07 years following initial infection. Plasma samples chosen for analysis were collected at a median time point ~2.72 years post-SI. Because previous studies of singly infected populations with broad and potent Nab responses have shown that the majority of their neutralizing activity can be mapped to 4 main epitopes on the HIV-1 Envelope, we focused on these targets, which include the CD4-binding site, a V1/V2 glycan, the N332 supersite in V3, and the membrane proximal external region of gp41. Using standard epitope mapping techniques that were applied to the previous cohorts, the present study demonstrates that SI did not induce a dominant Nab response to any one of these epitopes in the 21 women. Computational sera delineation analyses also suggested that 20 of the 21 superinfected women’s Nab responses could not be ascribed a single specificity with high confidence. These data are consistent with a model in which SI with diverse subtypes promotes the development of a broad polyclonal Nab response, and thus would provide support for vaccine designs using multivalent HIV immunogens to elicit a diverse repertoire of Nabs.</p></div