Public survey instruments for business administration using social network analysis and big data

Purpose: The subject matter of this research is closely intertwined with the scientific discussion about the necessity of developing and implementing practice-oriented means of measuring social well-being taking into account the intensity of contacts between individuals. The aim of the research is to test the toolkit for analyzing social networks and to develop a research algorithm to identify sources of consolidation of public opinion and key agents of influence. The research methodology is based on postulates of sociology, graph theory, social network analysis and cluster analysis. Design/Methodology/Approach: The basis for the empirical research was provided by the data representing the reflection of social media users on the existing image of Russia and its activities in the Arctic, chosen as a model case. Findings: The algorithm allows to estimate the density and intensity of connections between actors, to trace the main channels of formation of public opinion and key agents of influence, to identify implicit patterns and trends, to relate information flows and events with current information causes and news stories for the subsequent formation of a "cleansed" image of the object under study and the key actors with whom this object is associated. Practical Implications: The work contributes to filling the existing gap in the scientific literature, caused by insufficient elaboration of the issues of applying the social network analysis to solve sociological problems. Originality/Value: The work contributes to filling the existing gap in the scientific literature formed as a result of insufficient development of practical issues of using analysis of social networks to solve sociological problems.peer-reviewe

E-learning as a modern resource of education

E-learning is becoming increasingly popular today. It is being widely implemented not only in educational institutions but in business and industrial enterprises demanding the fastest and the cheapest means of information exchange and communication. This article is dedicated to eliciting of the background factors of successful implementation and favourable environment to develop e-learning programs. It analyses the e-learning teaching process and methods practiced in several countries, including Russia, and empathizes the major issues and problems the national systems of education have had to face recentl

Late Antiquity: the regional specific nature of intellectual tradition

The primary purpose of the study is to investigate the specifics of the intellectual tradition prevailing in some regions of the Late Antique world. For the purpose of a comprehensive review of the problem, the authors focus on wellknown intellectuals of the 5th-6th centuries, representing Gaul (Ausonius, Sidonius, Ennodius et al.), Alexandria (John Philoponus, Hypatia, Sinesius of Cyrene et al.), Africa (Fulgentius, Priscian, Corippus), Isauria (Candidus Isaurus

Indicators of the cytokine system in practically healthy women of different ages and interrelation with the emotional state

Numerous studies show the role of the cytokine network in the pathogenesis of anxiety and depression. However, at present, studies of the correlation between the levels of pro-inflammatory and antiinflammatory cytokines and the level of emotional stress are rather few. The aim of the study was to analyze the serum levels of pro-inflammatory and anti-inflammatory cytokines and the emotional state in apparently healthy women depending on age. Serum levels were tested IL-1β, IL-6, IL-17, IFNγ, IL-10 and IL-4 in 100 apparently healthy women, who were divided into 3 groups depending on age (WHO): 18-44 (young age) 30 people, 45-59 (middle age) 40 people, 60-74 (old age) 30 people (sandwich variant of enzyme-linked immunosorbent assay, pg/mL). To assess the emotional component of health, all the subjects passed the questionnaire SF-36 “Assessment of the quality of life”. Statistical processing of the obtained data was carried out using the analytical software IBM SPSS Statistics, 22.0. In practically healthy women, an increase in the values of IL-1β and IL-6 was found in the elderly group (p < 0.05), while no differences were found between the groups of young and middle age. The level of IFNγ in all age groups of women did not differ significantly. At the same time, in the elderly group, the levels of IFNγ in 40% ranged from 1.04 to 8.76 pg/mL, and in 60% of women – from 24.85 to 28.5 pg/mL. IL-17 was also high (p < 0.05-0.01) in the group of women aged 60-74. In the anti-inflammatory link, the opposite picture was observed, for example, in young and middle-aged women, the levels of IL-10 and IL-4 were higher than in the elderly group. Thus, the analysis made it possible to state that the parameters of the cytokine profile and emotional state in women are associated with age

Случай регресса витилиго у пациента с псориазом и псориатическим артритом, получавшего терапию адалимумабом

The article discusses the common pathogenetic pathways of autoimmune skin diseases – psoriasis and vitiligo. Currently proposed treatments for vitiligo do not significantly reduce or completely restore skin pigmentation. The use of adalimumab for 6 years in a patient suffering from psoriasis, psoriatic arthritis (PsA), vitiligo and autoimmune thyroiditis made it possible to control the activity of psoriasis and PsA, and also contributed to the regression of depigmentation foci. The use of biologic disease-modifying antirheumatic drug therapy in this group of patients in order to achieve repigmentation may be promising. В статье рассматриваются общие звенья патогенеза аутоиммунных заболеваний кожи – псориаза и витилиго. Предлагаемые в настоящее время методы лечения витилиго не позволяют добиться значительного уменьшения или полного восстановления пигментации кожи. Применение адалимумаба в течение 6 лет у пациента, страдающего псориазом, псориатическим артритом (ПсА), витилиго и аутоиммунным тиреоидитом, позволило контролировать активность псориаза и ПсА, а также способствовало регрессу очагов депигментации.Использования генно-инженерной биологической терапии у данной группы пациентов с целью достижения репигментации может быть перспективным

QTL АНАЛИЗ МОРФОЛОГИЧЕСКИХ ПРИЗНАКОВ КАЧЕСТВА У BRASSICA RAPA L.

Using of the DH–lines of two mapping populations of Brassica rapa L, the morpho–biological investigation and mapping of QTLs determined some morphological traits of quality in greenhouse's condition have been done. The linkage groups of QTLs of the following quantitative traits have been identified and localized: length, width, color, hairiness, and surface of lamina, as well as petiole length and width caused of nutritive value of B. rapa plants. The molecular markers genetically linked with mapped QTLs were revealed. The percent of phenotypic variability determined by the identified chromosome loci was calculated.С использованием линий двойных гаплоидов двух картирующих популяций Brassica rapa L. проведено морфобиологическое изучение и картирование QTL (quantitative trait loci), определяющих проявление ряда морфологических признаков качества в условиях теплицы. Идентифицированы и локализованы на группах сцепления QTL таких признаков качества, как длина, ширина, окраска, опушенность, характер поверхности листовой пластинки, а также длина и ширина черешка, обуславливающих питательную ценность данного вида растений. Выявлены молекулярные маркеры, генетически сцепленные с картированными QTL, и установлен процент фенотипической изменчивости, определяемый идентифицированными локусами хромосом

Evaluation of the influence of Inosine pranobex on the matrix protein system in patients with chronic viral cervicitis

The reproductive potential of both women and men is declining every year. Many factors contribute to the violation of the reproductive function – chemical, physical, mechanical, psychogenic, however, biological factors have the most pronounced effect on reproduction. Chronic viral cervicitis can be not only the cause of infertility and reproductive losses, but also the development of intraepithelial dysplasia, as well as cervical cancer. PVI, as a monoinfection, is quite rare along with HPV. Other UGIs (urogenital infections) act as common routes of transmission and entry gates. The most common association with PVI is herpesvirus infection. An increase in MMP, both systemically and at the local level, may indicate a violation of cell modeling processes, which contributes to the development of autoimmune inflammation with further destruction of the tissues of the reproductive tract. Activation of MMP promotes the release of HSV from the nerve ganglia and reactivation of the infection. Therapy for HPV and HVI (herpes virus infections) are debatable. There is no single standard of treatment, but there are a number of drugs that have antiviral and immunomodulatory effects. Currently, there are no studies on the dynamics of the effect of HPV and HSV infection on the state of MMPs and TIMPs during Inosine pranobex therapy. Objective: to evaluate changes in matrix metalloproteinases 2 and 9 and their tissue inhibitors types 1 and 2 in patients with human papillomavirus and herpes infections after Inosine pranobex therapy. 6 patients with papillomavirus and herpetic infections were examined and treated with drugs containing the active ingredient Inosine pranobex. The levels of MMP-2, MMP-9 and TIMP-1, TIMP-2 in blood serum were determined using specific reagents from R&D Diagnostics Inc. (USA). The dynamics of indicators in the blood serum of patients with PVI showed a decrease in the level of MMP-2, MMP-9, TIMP-1 with a simultaneous increase in TIMP-2 relative to the values before therapy. In patients with PVI and HVI, Inosine pranobex therapy showed a decrease in MMP-2 and MMP-9 levels, no changes in the content of TIMP-1, but an increase in the serum content of TIMP-2. Prior to the use of therapy, an increase in the ratio in the main groups in comparison with the control group was found, however, the largest increase was found in the group with the association of infections. After therapy, positive dynamics was established in the main groups. Thus, the ratio in group I decreased and became equal to the control values. In the II group of patients, the ratio, despite the decrease, remained higher than the control values and higher in comparison with the I group of women

Quantum Entanglement in Nitrosyl Iron Complexes

Recent magnetic susceptibility measurements for polycrystalline samples of binuclear nitrosyl iron complexes [Fe_2(C_3H_3N_2S)_2(NO)_4] (I) and [Fe_2(SC_3H_5N_2)_2(NO)_4] (II), suggest that quantum-mechanical entanglement of the spin degrees of freedom exists in these compounds. Entanglement E exists below the temperature T_E that we have estimated for complexes I and II to be 80-90 and 110-120 K, respectively. Using an expression of entanglement in terms of magnetic susceptibility for a Heisenberg dimer, we find the temperature dependence of the entanglement for complex II. Having arisen at the temperature T_E, the entanglement increases monotonically with decreasing temperature and reaches 90-95% in this complex at T=25 K, when the subordinate effects are still small.Comment: 8 page

СРЕДНЕМИОЦЕНОВЫЕ ПОСЛЕДОВАТЕЛЬНОСТИ ВЫСОКО- И УМЕРЕННО-MG ВУЛКАНИЧЕСКИХ ПОРОД НА ВИТИМСКОМ ПЛОСКОГОРЬЕ, ЮГ СИБИРИ: ВОЗДЕЙСТВИЕ ПОДЛИТОСФЕРНОГО КОНВЕКТИРУЮЩЕГО МАТЕРИАЛА НА ЛИТОСФЕРУ

A comparative study of major elements, trace elements, and isotopes in high- and moderate-Mg volcanic sequences of 16–14 and 14–13 Ma, respectively, has been performed in the Bereya volcanic center. In the former (small volume) sequence, contaminated by crustal material basalts and trachybasalts of K–Na series were followed by uncontaminated basanites and basalts of transitional (K–Na–K) compositions and afterwards by picrobasalts and ba­salts of K series. From pressure estimates using equation [Scarrow, Cox, 1995], high-Mg magma originated at the deep range of 115–150 km. In the latter (high-volume) sequence, basalts and basaltic andesites of transitional (Na–K–Na) compositions and basalts of Na series were overlain by basalts and trachybasalts of K–Na series. First, there was a strong melting of its shallow garnet-free part with coeval weak melting of more deep garnet-bearing portion, then only a deep garnet-bearing portion of the lithospheric mantle melted. It is suggested that the sequential formation of high- and moderate-Mg melts reflected the mid-Miocene thermal impact of the lithosphere by hot material from the Transbaikalian low-velocity domain, which had the potential temperature Tp as high as 1510 °С. This thermal impact triggered the rifting in the lithosphere of the Baikal Rift System.В восточной части Витимского плоскогорья, в Береинском вулканическом центре, выполнено сравнительное изучение вариаций петрогенных оксидов, микроэлементов и изотопов в последовательностях высоко- и умеренно-Mg вулканитов, извергавшихся, соответственно, 16–14 и 14–13 млн лет назад. В первой (малообъемной) последовательности определена смена контаминированных коровым материалом базальтов–трахибазальтов K–Na-серии неконтаминированными высоко-Mg базанитами–базальтами переходного (K–Na–K) состава и пикробазальтами–базальтами K-серии. По оценкам давлений с использованием уравнения [Scarrow, Cox, 1995], высоко-Mg магмы выплавлялись в глубинном интервале 115–150 км. Во второй (крупнообъемной) последовательности выявлена смена базальтов–андезибазальтов переходного (Na–K–Na) состава и базальтов Na-серии базальтами–трахибазальтами K–Na-серии. Сначала произошло сильное плавление малоглубинной безгранатовой части литосферной мантии (или с небольшим содержанием граната) с одновременным слабым плавлением более глубинного субстрата, обогащенного гранатом, а затем продолжал слабо плавиться только ее более глубинный субстрат. Предполагается, что последовательное образование высоко- и умеренно-Mg выплавок отразило среднемиоценовое термальное воздействие на литосферу горячего материала Забайкальского низкоскоростного домена, обладавшего высокой потенциальной температурой (до 1510 °С). Это термальное воздействие вызвало рифтогенез в литосфере Байкальской рифтовой системы

Protecting Mice from H7 Avian Influenza Virus by Immunisation with a Recombinant Adenovirus Encoding Influenza A Virus Conserved Antigens

Influenza is a highly contagious disease that causes annual epidemics and occasional pandemics. Birds are believed to be the source of newly emerging pandemic strains, including highly pathogenic avian influenza viruses of the subtype H7. The aim of the study: to evaluate the ability of the recombinant human adenovirus, serotype 5, which expresses genes of influenza A highly conserved antigens (ion channel M2 and nucleoprotein NP), to provide protection to laboratory mice against infection with a lethal dose of avian influenza virus, subtype H7. To achieve this goal, it was necessary to adapt influenza A virus, subtype H7 for reproduction in the lungs of mice, to characterise it, and to use it for evaluation of the protective properties of the recombinant adenovirus. Materials and methods: avian influenza virus A/Chicken/NJ/294508-12/2004 (H7N2) was adapted for reproduction in the lungs of mice by repeated passages. The adapted strain was sequenced and assessed using hemagglutination test, EID50 and LD50 for laboratory mice. BALB/c mice were immunised once with Ad5-tet-M2NP adenovirus intranasally, and 21 days after the immunisation they were infected with a lethal dose (5 LD50) of influenza virus A/Chicken/NJ/294508-12/2004 (H7N2) in order to assess the protective properties of the recombinant adenovirus. The level of viral shedding from the lungs of the infected mice was evaluated by titration of the lung homogenates in MDCK cell culture on days 3 and 6 after infection. The level of specific antibodies to H7 avian influenza virus was determined by indirect enzyme immunoassay. Results: the use of Ad5-tet-M2NP adenovirus for immunisation of the mice ensured 100% survival of the animals that had disease symptoms (weight loss) after their infection with the lethal dose (5 LD50) of H7 avian influenza virus. The study demonstrated a high post-vaccination level of humoral immune response to H7 avian influenza virus. The virus titer decreased significantly by day 6 in the lungs of mice that had been immunised with Ad5-tet-M2NP compared to the control group. Conclusion: the Ad5-tetM2NP recombinant adenovirus can be used to create a candidate pandemic influenza vaccine that would protect against avian influenza viruses, subtype H7, in particular