The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillation

Background— The molecular mechanism of increased background inward rectifier current (IK1) in atrial fibrillation (AF) is not fully understood. We tested whether constitutively active acetylcholine (ACh)-activated IK,ACh contributes to enhanced basal conductance in chronic AF (cAF). Methods and Results— Whole-cell and single-channel currents were measured with standard voltage-clamp techniques in atrial myocytes from patients with sinus rhythm (SR) and cAF. The selective IK,ACh blocker tertiapin was used for inhibition of IK,ACh. Whole-cell basal current was larger in cAF than in SR, whereas carbachol (CCh)-activated IK,ACh was lower in cAF than in SR. Tertiapin (0.1 to 100 nmol/L) reduced IK,ACh in a concentration-dependent manner with greater potency in cAF than in SR (−logIC50: 9.1 versus 8.2; P<0.05). Basal current contained a tertiapin-sensitive component that was larger in cAF than in SR (tertiapin [10 nmol/L]-sensitive current at −100 mV: cAF, −6.7±1.2 pA/pF, n=16/5 [myocytes/patients] versus SR, −1.7±0.5 pA/pF, n=24/8), suggesting contribution of constitutively active IK,ACh to basal current. In single-channel recordings, constitutively active IK,ACh was prominent in cAF but not in SR (channel open probability: cAF, 5.4±0.7%, n=19/9 versus SR, 0.1±0.05%, n=16/9; P<0.05). Moreover, IK1 channel open probability was higher in cAF than in SR (13.4±0.4%, n=19/9 versus 11.4±0.7%, n=16/9; P<0.05) without changes in other channel characteristics. Conclusions— Our results demonstrate that larger basal inward rectifier K+ current in cAF consists of increased IK1 activity and constitutively active IK,ACh. Blockade of IK,ACh may represent a new therapeutic target in AF

Smart Antennas Made Practical: The SPIDA Way

Smart antennas are a specific type of directional antenna able to dynamically control the gain as a function of direction. This contrasts with more traditional directional antennas, where the dynamic ability is missing, and with omni-directional antennas, which are designed to have equal gain in all directions

Ultrasonic studies of the magnetic phase transition in MnSi

Measurements of the sound velocities in a single crystal of MnSi were performed in the temperature range 4-150 K. Elastic constants, controlling propagation of longitudinal waves reveal significant softening at a temperature of about 29.6 K and small discontinuities at $\sim$28.8 K, which corresponds to the magnetic phase transition in MnSi. In contrast the shear elastic moduli do not show any softening at all, reacting only to the small volume deformation caused by the magneto-volume effect. The current ultrasonic study exposes an important fact that the magnetic phase transition in MnSi, occurring at 28.8 K, is just a minor feature of the global transformation marked by the rounded maxima or minima of heat capacity, thermal expansion coefficient, sound velocities and absorption, and the temperature derivative of resistivity.Comment: 4 pages, 4 figure

Children's Planning Performance in the Zoo Map Task (BADS-C) : Is It Driven by General Cognitive Ability, Executive Functioning, or Prospection?

Preparation of this article was partially funded by the Swiss National Science Foundation (SNSF; 100014_152841) and the Natural Sciences and Engineering Council of Canada (NSERC; RGPIN-2015-03774).Peer reviewedPostprin

Line narrowing and spectral hole burning in single mode Nd³⁺- fibre lasers

Line-narrowing in the output spectrum of an Nd-doped silica-fiber laser with spectrally flat reflectors is interpreted to indicate substantial homogenous contribution to the 1.09µm fluorescent linewidth. Using a fiber Bragg-reflector, frequency-stable operation with 100GHz bandwidth is obtained, dominated by power broadening and spectral hole burning

Surface resonance of the (2×1) reconstructed lanthanum hexaboride (001)-cleavage plane : a combined STM and DFT study

We performed a combined study of the (001)-cleavage plane of lanthanum hexaboride (LaB6) using scanning tunneling microscopy and density-functional theory (DFT). Experimentally, we found a (2×1) reconstructed surface on a local scale. The reconstruction is only short-range ordered and tends to order perpendicularly to step edges. At larger distances from surface steps, the reconstruction evolves to a labyrinthlike pattern. These findings are supported by low-energy electron diffraction experiments. Slab calculations within the framework of DFT show that the atomic structure consists of parallel lanthanum chains on top of boron octahedra. Scanning tunneling spectroscopy shows a prominent spectral feature at −0.6eV. Using DFT, we identify this structure as a surface resonance of the (2×1) reconstructed LaB6 (100) surface which is dominated by boron dangling bond states and lanthanum d states

JUMPING STRATEGIES IN A VOLLEYBALL AND A BALLET SPECIFIC JUMP

INTRODUCTION The performance of a maximal vertical jump fram a static preparatory position (SQJ) or starting with a counter movement (CMJ) implies transformation of rotation about the hip, knee and ankle joints to a maximal translatory movement. Different strategies have been proposed for this transformation. Previously both sequential and simullaneous strategies have been proposed as optimal for maximal vertical jumping (1 & 2). The purpose of this study was to analyze ]umping strategies in a sport and dance specific maximal vertical jump. The hypothesis was that the technical demands of the Jumps would preset the strategy. Six male subjects participated in the study three professional ballet dancers and three elite volleyball players. In the ballet specific jump (BSJ) the legs were outward rotated, one foot was placed in front of and close to the other foot and the upper body kept upright. Three elite volleyball players performed the jump used for the smash (VSJ) including a three step preliminary run up and a farcefull arm swing. Afterwards all six subjects performed SQJ and CMJ. The ]umps were recorded on high speed film (500Hz) combined with registrations trom an AMTI force platform and EMG recordings from the major lower extremity muscles Net joint moments and joint work ware calculated by inverse dynamics. The strategy of the jumps was determined on the basis of angular kinematics and the pattern of nel joint moments of the two dominant joints RESULTS For BSJ the jumping height (h) was 0.22O.28m.The war!< contribution from the knee and ankle joint were 50-70% and 47-63% of the total work respectively while the work at the hip joint showed a negative contribution of 13-17% caused by a net hip flexor moment. Because of the specific ballet position the hip extension took place in the frontal plane and mgluteus maximus could not contribute to the extension. The concentric activity in mrectus femoris could partly explain the hip flexor moment. The knee and ankle joint initiated the extension phase simultaneously and the net joint moments peaked also simultaneously Therefore, the strategy could be defined as simultaneous. For VSJ h was 0.310.45m. The work contribution fram the knee and hip joints were 22-60% and 35-62% of the total work respectively. The hip joint began the extension phase before the body center of mass had reached its lowest position (sn The knee extension began 40-100ms after s.j. The peaks of the net joint moments of the hip and knee showed a similar pattern. Accordingly, the strategy could be defined as sequentiaL The sequential joint extension could partly be explained by the forcefull armswing pressing down and giving negative momentum in the downward phase and by this delaying the knee extension. In SQJ and CMJ h was 0.22-0.36m and 0.33-0AOm. The work contribution from the knee was 64.5%(SE 5.9) and 76.0% (SE 9.2) and from the hip 18.8% (SE 5.8) and 133% (SE 8.7). One ballet dancer and one volleyball player performed SQJ and CMJ with a simultaneous strategy while the otller four subjects used a sequential strategy. CONCLUSION In a maximal vertical jump fram ballet and from volleyball the technical demands preset the jumping strategy. When the subjects were asked to perform SQJ and CMJ the choice of strategy seemed individual and not connected to the training background. REFERENCES (1) Hudson, J.L. (1986). Med Sci. Sports Exerc, 18,242-251 (2) Babbert, M.F. & van lngen Schenau, G.J. (1986). J Biomechanics, 21, 249•26

Shear modulus of the hadron-quark mixed phase

Robust arguments predict that a hadron-quark mixed phase may exist in the cores of some "neutron" stars. Such a phase forms a crystalline lattice with a shear modulus higher than that of the crust due to the high density and charge separation, even allowing for the effects of charge screening. This may lead to strong continuous gravitational-wave emission from rapidly rotating neutron stars and gravitational-wave bursts associated with magnetar flares and pulsar glitches. We present the first detailed calculation of the shear modulus of the mixed phase. We describe the quark phase using the bag model plus first-order quantum chromodynamics corrections and the hadronic phase using relativistic mean-field models with parameters allowed by the most massive pulsar. Most of the calculation involves treating the "pasta phases" of the lattice via dimensional continuation, and we give a general method for computing dimensionally continued lattice sums including the Debye model of charge screening. We compute all the shear components of the elastic modulus tensor and angle average them to obtain the effective (scalar) shear modulus for the case where the mixed phase is a polycrystal. We include the contributions from changing the cell size, which are necessary for the stability of the lower-dimensional portions of the lattice. Stability also requires a minimum surface tension, generally tens of MeV/fm^2 depending on the equation of state. We find that the shear modulus can be a few times 10^33 erg/cm^3, two orders of magnitude higher than the first estimate, over a significant fraction of the maximum mass stable star for certain parameter choices.Comment: 22 pages, 12 figures, version accepted by Phys. Rev. D, with the corrections to the shear modulus computation and Table I given in the erratu