MANAGEMENT DECISION-MAKING IN THE TRANSFORMATION OF HIGHER EDUCATION

The main directions of the transformation of higher education in the Russian Federation. Clarifications on the role of leadership in the management decision-making in higher education. The formation of a broad group of larger competitive at the national level, regional universities and their focus on quality training of specialists in demand on the regional labor market. Obtained problem management decision-making, strategy development and their relationship with the state policy in the sphere of higher education

MANAGEMENT DECISION-MAKING IN THE TRANSFORMATION OF HIGHER EDUCATION

The main directions of the transformation of higher education in the Russian Federation. Clarifications on the role of leadership in the management decision-making in higher education. The formation of a broad group of larger competitive at the national level, regional universities and their focus on quality training of specialists in demand on the regional labor market. Obtained problem management decision-making, strategy development and their relationship with the state policy in the sphere of higher education

«Ten Questions a Hundred Famous Russian People» as Format Student Television Broadcasting

The article is devoted to the problems of designing television broadcasting for students NWIM RANEPA by example implementation of the television project «Ten questions a hundred famous Russian people». This media product has its own unique. It is created from beginning to the end by the students themselves, studying in the field of training “Journalism” NWIM RANEPA. The authors of the article comprehensively analyzed all technological and creative aspects of this project. In their opinion, the project «Ten questions a hundred famous Russian people» became an experimental platform where the most brave decisions and approaches in studying autobiographies of famous people were tested, where students can engage in self-directed practice activities and mastering of various television specialties: cameraman, producer, TV presenter, editor, sound engineer, screenwriter, correspondent, editor. Therefore the project harmonically joined in the educational process to carry out educational and enlightening functions

The role of the state in the financing sources’ formation of industrial enterprises’ innovative activities

Currently, the external conditions for the functioning of industrial enterprises are formed in such a way that the achievement of their goals is seen impossible without the implementation of innovative activities. Due to the high cost of innovations, as well as the need to conduct these processes on an ongoing basis, industrial enterprises lack their own funds to finance innovation activities. The state is interested in the innovative development of industrial enterprises. This is one of the reasons why it participates in the formation of their funding sources. The article substantiates the need for state support, as well as analyzes the options for its provision by type of financing sources. For each type of sources, options for providing large-scale support, implying a large coverage area, as well as point-directed support, are also highlighted

RET Rearrangements in Lung Adenocarcinoma and Radiation

Background:RET rearrangement, a hallmark of radiation-induced thyroid cancer, has been reported to occur in 1% of lung adenocarcinoma patients. Patients with this rearrangement tend to be younger and never smokers, raising a possibility of other causes, such as radiation. We hypothesized that RET chromosomal rearrangement may represent a genetic mechanism of radiation-induced lung cancer.Methods:Two hundred forty-five consecutive primary lung adenocarcinomas without history of radiation and 38 lung adenocarcinoma patients with a history of therapeutic radiation for breast carcinoma or mediastinal Hodkgin lymphoma were tested for RET rearrangement by fluorescence in situ hybridization. Human lung adenocarcinoma cells (201T) were subjected to γ radiation and tested for RET gene fusions by reverse transcriptase-polymerase chain reaction and Southern blot hybridization.Results:We identified one case with RET rearrangement in the group without history of radiation (1 of 240; 0.4%) and two cases in the group with history of radiation (2 of 37; 5.4%; P=0.0436). Both these patients were women, who were former smokers with a history of breast carcinoma treated with surgery and radiation. Furthermore, we found that RET fusions could be directly induced in 201T human lung cells by exposure to 1 Gy of γ radiation. All fusions identified were between RET and KIF5B genes, and no RET fusions to CCDC6 or NCOA4 genes, characteristic for thyroid cancer, were identified in the irradiated lung cells.Conclusion:RET fusions may represent a genetic mechanism of radiation-induced lung adenocarcinoma

Escalation as a way to resolve conflicts and contradictions

The domestic and foreign practice of project conflict management and resolution is analysed. The concepts of “conflict” and “contradiction” are differentiated. The modern point of view on the essence of the conflict is revealed, suggesting that the conflict does not always have negative consequences. In some cases, it is necessary to increase the effectiveness of the project implementation, so sometimes managers are required to stimulate its development (escalation of the conflict). The specific features of the escalation of the conflict and its relevance in a particular conflict situation are determined. The psychological features of the conflict escalation are analysed, which are manifested in the reluctance of domestic leaders to take the problem higher because of the fear of not being able to cope with the management of the conflict. Strategies for managing project conflicts are highlighted, and a conceptual model for managing them is proposed

Expansion of anti-AFP Th1 and Tc1 responses in hepatocellular carcinoma occur in different stages of disease

Copyright @ 2010 Cancer Research UK. This work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/.Background: α-Fetoprotein (AFP) is a tumour-associated antigen in hepatocellular carcinoma (HCC) and is a target for immunotherapy. However, there is little information on the pattern of CD4 (Th1) and CD8 (Tc1) T-cell response to AFP in patients with HCC and their association with the clinical characteristics of patients. Methods: We therefore analysed CD4 and CD8 T-cell responses to a panel of AFP-derived peptides in a total of 31 HCC patients and 14 controls, using an intracellular cytokine assay for IFN-γ. Results: Anti-AFP Tc1 responses were detected in 28.5% of controls, as well as in 25% of HCC patients with Okuda I (early tumour stage) and in 31.6% of HCC patients with stage II or III (late tumour stages). An anti-AFP Th1 response was detected only in HCC patients (58.3% with Okuda stage I tumours and 15.8% with Okuda stage II or III tumours). Anti-AFP Th1 response was mainly detected in HCC patients who had normal or mildly elevated serum AFP concentrations (P=0.00188), whereas there was no significant difference between serum AFP concentrations in these patients and the presence of an anti-AFP Tc1 response. A Th1 response was detected in 44% of HCC patients with a Child–Pugh A score (early stage of cirrhosis), whereas this was detected in only 15% with a B or C score (late-stage cirrhosis). In contrast, a Tc1 response was detected in 17% of HCC patients with a Child–Pugh A score and in 46% with a B or C score. Conclusion: These results suggest that anti-AFP Th1 responses are more likely to be present in patients who are in an early stage of disease (for both tumour stage and liver cirrhosis), whereas anti-AFP Tc1 responses are more likely to be present in patients with late-stage liver cirrhosis. Therefore, these data provide valuable information for the design of vaccination strategies against HCC.Association for International Cancer Research and Polkemmet Fund, London Clinic

THE STUDY OF DIAGNOSTIC POTENTIAL OF MONOCLONAL ANTIBODIES SPECIFIC TO THE MEMBRANE PROTEIN OF CHOLERA AGENT IN ENZYME-LINKED IMMUNOASSAY

Objective of the study was to develop peroxidase conjugate on the base of monoclonal antibodies (MCA) H2F6 and to study the possibility of its application for the detection of tcp+ Vibrio cholerae O1/O139 strains using direct ELISA methods.Materials and methods. Utilized for the investigation was the hybrid H2F6 clone, which synthesized monoclonal antibodies specific to the outer membrane protein of cholera vibrio into culture medium.Results and conclusions. Peroxidase conjugate was designed on the base of MCA which allows for the detection of tcp+ V. cholerae O1 and O139 strains in direct solid-phase enzyme-linked immunosorbent assay and dot-ELISA. The preparation was tested on a group of strains of V. cholerae and heterologous microorganisms and showed specificity in relation to V. cholerae O1 and O139. Monoclonal peroxidase conjugate H2F6 can be used for the detection of epidemically significant V. cholerae O1/O139 strains by means of immune-enzyme methods

Электромагнитные поля компактных люминесцентных энергосберегающих ламп

The questions related to potential environmental and hygienic hazard, which may be caused by electromagnetic field of compact energy saving lamps, are considered. The results of measurements of electromagnetic fields in low frequency domain: spectral composition, intensity depending on distance for lamps of various types and power consumption are presented. It is shown that maximum value of electromagnetic field frequency of 50 Hz from the measured energy saving lamps does not exceed the maximum permissible levels.Рассматриваются вопросы, связанные с возможной эколого-гигиенической опасностью, которые могут представлять электромагнитные поля компактных энергосберегающих ламп. Приведенырезультаты измерений электромагнитных полей в низкочастотной области: спектрального состава, напряженности в зависимости от расстояния для ламп различных видов и потребляемой мощности. Показано, что максимальные величины напряженности электромагнитного поля частотой 50 Гц от измеренных энергосберегающих ламп не превышают предельно допустимых уровней

Non-alcoholic fatty liver disease and metabolic liver dysfunction in the new coronavirus infection COVID-19

Our study aimed to explore associated non-alcoholic fatty liver disease (NAFLD) and metabolic liver dysfunction influence on the severity of the new coronavirus infection COVID-19. Material and methods. The study design was a cross-sectional study. The research included 215 patients (39.50 % of men) aged 26–60 years who had undergone a new coronavirus infection COVID-19 at least two months ago. Participants were divided into three groups by severity of infection: mild (n = 99), moderate and severe (n = 116) by anamnesis. Hepatic steatosis index (HIS), body mass index (BMI), waist circumference, alanine aminotransferase and gamma-glutamyl transpeptidase activity, glucose and triglyceride content, systolic and diastolic pressure were calculated and abdominal ultrasound examination was done. Results. In the group with moderate and severe course of COVID-19, the proportion of patients diagnosed with NAFLDaccording to the HSI index was significantly higher compared to patients with mild coronavirus infection. Patients with mild COVID-19, who were diagnosed with NAFLD, had higher alanine aminotransferase and gamma-glutamyl transpeptidase activity, glucose and triglyceride content, BMI, systolic and diastolic pressure, waist circumference compared to patients without NAFLD. Similar differences persisted for patients with moderate and severe course. With the step-by-step exclusion of cardiometabolic parameters from the logistic regression model, the triglyceride content and BMI retained association with steatohepatosis according to ultrasound data, regardless of severity. When creating a similar model for the HSI index, significant correlation was shown for alanine aminotransferase activity in patients with mild COVID-19, for alanine aminotransferase activity and BMI – in patients with moderate and severe COVID-19. Conclusions. Patients with NAFLD have a more severe course of COVID-19. In addition, associations of the severity of COVID-19 with a combination of NAFLD and other cardiometabolic changes in the body, such as arterial hypertension, obesity, dyslipidemia, were revealed