6,608 research outputs found
Demonstration of the Zero-Crossing Phasemeter with a LISA Test-bed Interferometer
The Laser Interferometer Space Antenna (LISA) is being designed to detect and
study in detail gravitational waves from sources throughout the Universe such
as massive black hole binaries. The conceptual formulation of the LISA
space-borne gravitational wave detector is now well developed. The
interferometric measurements between the sciencecraft remain one of the most
important technological and scientific design areas for the mission.
Our work has concentrated on developing the interferometric technologies to
create a LISA-like optical signal and to measure the phase of that signal using
commercially available instruments. One of the most important goals of this
research is to demonstrate the LISA phase timing and phase reconstruction for a
LISA-like fringe signal, in the case of a high fringe rate and a low signal
level. We present current results of a test-bed interferometer designed to
produce an optical LISA-like fringe signal previously discussed in the
literature.Comment: find minor corrections in the CQG versio
A Demonstration of LISA Laser Communication
Over the past few years questions have been raised concerning the use of
laser communications links between sciencecraft to transmit phase information
crucial to the reduction of laser frequency noise in the LISA science
measurement. The concern is that applying medium frequency phase modulations to
the laser carrier could compromise the phase stability of the LISA fringe
signal. We have modified the table-top interferometer presented in a previous
article by applying phase modulations to the laser beams in order to evaluate
the effects of such modulations on the LISA science fringe signal. We have
demonstrated that the phase resolution of the science signal is not degraded by
the presence of medium frequency phase modulations.Comment: minor corrections found in the CQG versio
LISA Science Results in the Presence of Data Disturbances
Each spacecraft in the Laser Interferometer Space Antenna houses a proof mass
which follows a geodesic through spacetime. Disturbances which change the proof
mass position, momentum, and/or acceleration will appear in the LISA data
stream as additive quadratic functions. These data disturbances inhibit signal
extraction and must be removed. In this paper we discuss the identification and
fitting of monochromatic signals in the data set in the presence of data
disturbances. We also present a preliminary analysis of the extent of science
result limitations with respect to the frequency of data disturbances
Collective excitation of a Bose-Einstein condensate by modulation of the atomic scattering length
We excite the lowest-lying quadrupole mode of a Bose-Einstein condensate by
modulating the atomic scattering length via a Feshbach resonance. Excitation
occurs at various modulation frequencies, and resonances located at the natural
quadrupole frequency of the condensate and at the first harmonic are observed.
We also investigate the amplitude of the excited mode as a function of
modulation depth. Numerical simulations based on a variational calculation
agree with our experimental results and provide insight into the observed
behavior.Comment: Submitted to PR
Morphogenetic Mechanisms of Epithelial Tubulogenesis: MDCK Cell Polarity Is Transiently Rearranged without Loss of Cell–Cell Contact during Scatter Factor/Hepatocyte Growth Factor-Induced Tubulogenesis
AbstractMany organ systems are composed of networks of epithelial tubes. Recently, molecules that induce development of epithelial tubules and regulate sites of branching have been identified. However, little is known about the mechanisms regulating cell rearrangements that are necessary for tubule formation. In this study we have used a scatter factor/hepatocyte growth factor-induced model system of MDCK epithelial cell tubulogenesis to analyze the mechanisms of cell rearrangement during tubule development. We examined the dynamics of cell polarity and cell–cell junctions during tubule formation and present evidence for a multistep model of tubulogenesis in which cells rearrange without loss of cell–cell contacts and tubule lumens formde novo.A three-dimensional analysis of markers for apical and basolateral membrane subdomains shows that epithelial cell polarity is transiently lost and subsequently regained during tubulogenesis. Furthermore, components of cell–cell junctional complexes undergo profound rearrangements: E-cadherin is randomly distributed around the cell surface, desmoplakins I/II accumulate intracellularly, and the tight junction protein ZO-1 remains localized at sites of cell–cell contact. This suggests that differential regulation of cell–cell junctions is important for the formation of tubules. Therefore, during tubulogenesis, cell–cell adhesive contacts are differentially regulated while the polarity and specialization of plasma membrane subdomains reorganize, enabling cells to remain in contact as they rearrange into new structures
Dissipative Transport of a Bose-Einstein Condensate
We investigate the effects of impurities, either correlated disorder or a
single Gaussian defect, on the collective dipole motion of a Bose-Einstein
condensate of Li in an optical trap. We find that this motion is damped at
a rate dependent on the impurity strength, condensate center-of-mass velocity,
and interatomic interactions. Damping in the Thomas-Fermi regime depends
universally on the disordered potential strength scaled to the condensate
chemical potential and the condensate velocity scaled to the peak speed of
sound. The damping rate is comparatively small in the weakly interacting
regime, and the damping in this case is accompanied by strong condensate
fragmentation. \textit{In situ} and time-of-flight images of the atomic cloud
provide evidence that this fragmentation is driven by dark soliton formation.Comment: 14 pages, 20 figure
Circumnuclear Star Clusters in the Galaxy Merger NGC 6240, Observed with Keck Adaptive Optics and HST
We discuss images of the central ~10 kpc (in projection) of the galaxy merger
NGC 6240 at H and K' bands, taken with the NIRC2 narrow camera on Keck II using
natural guide star adaptive optics. We detect 28 star clusters in the NIRC2
images, of which only 7 can be seen in the similar-spatial-resolution, archival
WFPC2 Planetary Camera data at either B or I bands. Combining the NIRC2 narrow
camera pointings with wider NICMOS NIC2 images taken with the F110W, F160W, and
F222M filters, we identify a total of 32 clusters that are detected in at least
one of these 5 infrared (lambda > 1 micron) bandpasses. By comparing to
instantaneous burst, stellar population synthesis models (Bruzual & Charlot
2003), we estimate that most of the clusters are consistent with being ~15 Myr
old and have photometric masses ranging from 7E5 M_sun to 4E7 M_sun. The total
contribution to the star formation rate (SFR) from these clusters is
approximately 10 M_sun/year, or ~10% of the total SFR in the nuclear region. We
use these newly discovered clusters to estimate the extinction toward NGC
6240's double nuclei, and find values of A_V as high as 14 magnitudes along
some sightlines, with an average extinction of A_V~7 mag toward sightlines
within ~3 arcsec of the double nuclei.Comment: 37 pages, 9 figures; Accepted for publication by Ap
Antibody-Based Ticagrelor Reversal Agent in Healthy Volunteers.
BACKGROUND: Ticagrelor is an oral P2Y12 inhibitor that is used with aspirin to reduce the risk of ischemic events among patients with acute coronary syndromes or previous myocardial infarction. Spontaneous major bleeding and bleeding associated with urgent invasive procedures are concerns with ticagrelor, as with other antiplatelet drugs. The antiplatelet effects of ticagrelor cannot be reversed with platelet transfusion. A rapid-acting reversal agent would be useful.
METHODS: In this randomized, double-blind, placebo-controlled, phase 1 trial, we evaluated intravenous PB2452, a monoclonal antibody fragment that binds ticagrelor with high affinity, as a ticagrelor reversal agent. We assessed platelet function in healthy volunteers before and after 48 hours of ticagrelor pretreatment and again after the administration of PB2452 or placebo. Platelet function was assessed with the use of light transmission aggregometry, a point-of-care P2Y12 platelet-reactivity test, and a vasodilator-stimulated phosphoprotein assay.
RESULTS: Of the 64 volunteers who underwent randomization, 48 were assigned to receive PB2452 and 16 to receive placebo. After 48 hours of ticagrelor pretreatment, platelet aggregation was suppressed by approximately 80%. PB2452 administered as an initial intravenous bolus followed by a prolonged infusion (8, 12, or 16 hours) was associated with a significantly greater increase in platelet function than placebo, as measured by multiple assays. Ticagrelor reversal occurred within 5 minutes after the initiation of PB2452 and was sustained for more than 20 hours (P\u3c0.001 after Bonferroni adjustment across all time points for all assays). There was no evidence of a rebound in platelet activity after drug cessation. Adverse events related to the trial drug were limited mainly to issues involving the infusion site.
CONCLUSIONS: In healthy volunteers, the administration of PB2452, a specific reversal agent for ticagrelor, provided immediate and sustained reversal of the antiplatelet effects of ticagrelor, as measured by multiple assays. (Funded by PhaseBio Pharmaceuticals; ClinicalTrials.gov number, NCT03492385.)
Thermal gradient-induced forces on geodetic reference masses for LISA
The low frequency sensitivity of space-borne gravitational wave observatories
will depend critically on the geodetic purity of the trajectories of orbiting
test masses. Fluctuations in the temperature difference across the enclosure
surrounding the free-falling test mass can produce noisy forces through several
processes, including the radiometric effect, radiation pressure, and
outgassing. We present here a detailed experimental investigation of thermal
gradient-induced forces for the LISA gravitational wave mission and the LISA
Pathfinder, employing high resolution torsion pendulum measurements of the
torque on a LISA-like test mass suspended inside a prototype of the LISA
gravitational reference sensor that will surround the test mass in orbit. The
measurement campaign, accompanied by numerical simulations of the radiometric
and radiation pressure effects, allows a more accurate and representative
characterization of thermal-gradient forces in the specific geometry and
environment relevant to LISA free-fall. The pressure dependence of the measured
torques allows clear identification of the radiometric effect, in quantitative
agreement with the model developed. In the limit of zero gas pressure, the
measurements are most likely dominated by outgassing, but at a low level that
does not threaten the LISA sensitivity goals.Comment: 21 pages, 16 figures, submitted to Physical Review
Finite temperature phase transition for disordered weakly interacting bosons in one dimension
It is commonly accepted that there are no phase transitions in
one-dimensional (1D) systems at a finite temperature, because long-range
correlations are destroyed by thermal fluctuations. Here we demonstrate that
the 1D gas of short-range interacting bosons in the presence of disorder can
undergo a finite temperature phase transition between two distinct states:
fluid and insulator. None of these states has long-range spatial correlations,
but this is a true albeit non-conventional phase transition because transport
properties are singular at the transition point. In the fluid phase the mass
transport is possible, whereas in the insulator phase it is completely blocked
even at finite temperatures. We thus reveal how the interaction between
disordered bosons influences their Anderson localization. This key question,
first raised for electrons in solids, is now crucial for the studies of atomic
bosons where recent experiments have demonstrated Anderson localization in
expanding very dilute quasi-1D clouds.Comment: 8 pages, 5 figure
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