Evaluation of the efficacy and safety of the 7% hypertonic solution with hyaluronic acid in patients with COVID-19 in the outpatient phase

Introduction. Since 2020, the pandemic caused by the SARS-CoV-2 virus poses a serious threat to health systems in many countries around the world. Finding inexpensive and affordable, effective and safe medications that can promote rapid recovery and reduce the risk of a severe course of COVID-19 is an important challenge for the health care system of any country. It has long been known that 7% hypertonic sodium chloride solution has nonspecific antiviral, antibacterial and antifungal properties. A 2020 study shows the effectiveness of hypertonic NaCl solutions in blocking SARS-CoV-2 replication in Vero cells. These data suggest that hypertonic solutions can be used as a prophylactic and alternative comprehensive treatment for patients with COVID-19.Aim. We study the efficacy and safety of hypertonic solution with hyaluronic acid in patients undergoing outpatient treatment with mild to moderate COVID-19.Materials and methods. We conducted an open prospective study of the use of hyaluronic acid (HA) solution 7% (Ingasalin® forte 7%) in outpatients with confirmed SARS-CoV-2 infection who had 1 or more risk factors for a severe course of the disease. Patients were divided into 2 groups of 30 patients each. The main group received, in addition to standard therapy (according to the interim guidelines in effect at the time of treatment, version 14 dated 12/27/21), inhalation of 7% HG with HA in the morning and evening for 10 days; patients in the control group received standard therapy according to the interim guidelines.Results and discussion. Patients of the study group who received hyaluronic acid solution 7%  had statistically significant decrease of dyspnea and normalization of saturation values already on the 5th day of therapy compared to patients of the control group. One patient in the study group was hospitalized, and 4 patients in the control group were hospitalized. There were no side effects associated with the administration of hyaluronic acid solution 7%. Also, there was no development of cough or its intensification against the background of inhalation in patients of the main group.Conclusion. It is reasonable to use hyaluronic acid solution 7% in outpatients with mild to moderate COVID-19 and with one or more risk factors of severe disease course as part of complex therapy

The IRIS Network of Excellence: Future Directions in Interactive Storytelling

International audienceThe IRIS Network of Excellence started its work in January 2009. In this paper we highlight some new research directions developing within the network: one is revisiting narrative formalisation through the use of Linear Logic and the other is challenging the conventional framework of basing Interactive Storytelling on computer graphics to explore the content-based recombination of video sequences

Спектры эффективной проницаемости и потерь в магнитных композитных пленках

The research was devoted to a studying of the spectra effective permeability and losses in the magnetic composite films at different ratios of concentrations of metal and dielectric. The effective permeability was determined from the ratio of capacitance of the capacitor with a film (magnetic metal-dielectric) and without film. The results the permeability spectra for films for different composition and concentration of metals and dielectrics showed that they had similar trend of behavior in generalИсследование посвящено изучению спектров эффективной проницаемости и потерь в магнитных композитных пленках при различных соотношениях концентраций металлической и диэлектри- ческой фаз. Эффективная проницаемость определяется из соотношения емкости конденсатора с пленкой (магнитный металл-диэлектрик) и без пленки. В результате спектры проницаемости для пленок различного состава и концентраций металлов и диэлектриков показали, что они в целом имеют подобные тенденции в поведени

Спектры эффективной проницаемости и потерь в магнитных композитных пленках

The research was devoted to a studying of the spectra effective permeability and losses in the magnetic composite films at different ratios of concentrations of metal and dielectric. The effective permeability was determined from the ratio of capacitance of the capacitor with a film (magnetic metal-dielectric) and without film. The results the permeability spectra for films for different composition and concentration of metals and dielectrics showed that they had similar trend of behavior in generalИсследование посвящено изучению спектров эффективной проницаемости и потерь в магнитных композитных пленках при различных соотношениях концентраций металлической и диэлектри- ческой фаз. Эффективная проницаемость определяется из соотношения емкости конденсатора с пленкой (магнитный металл-диэлектрик) и без пленки. В результате спектры проницаемости для пленок различного состава и концентраций металлов и диэлектриков показали, что они в целом имеют подобные тенденции в поведени

User-Defined Body Gestures for an Interactive Storytelling Scenario

Abstract. For improving full body interaction in an interactive storytelling scenario, we conducted a study to get a user-defined gesture set. 22 users performed 251 gestures while running through the story script with real interaction disabled, but with hints of what set of actions was currently requested by the application. We describe our interaction design process, starting with the conduction of the study, continuing with the analysis of the recorded data including the creation of gesture taxonomy and the selection of gesture candidates, and ending with the integration of the gestures in our application