Unincorporated, Unprotected: Religion in an Established State

In the summer of 2004, the group American Veterans Standing for God and Country ( American Veterans ) began a cross-country pilgrimage to carry a 5,200-pound statue of the Ten Commandments to Washington D.C. The infamous statue cost Roy Moore his job as Chief Justice of the Alabama Supreme Court when he refused to remove it from the lobby of the state courthouse in 2002. American Veterans took up Moore\u27s cause, however, and in October they brought the Commandments statue to a Christian rally in Washington, D.C. The group then planned to ask Congress to display the statue permanently in the Capitol Building. The president of American Veterans also joined Moore in a campaign to enact legislation that would prohibit the Supreme Court from reviewing cases involving any government official\u27s acknowledgement of God as the sovereign source of law, liberty, or government. As Moore explained in his recent book, elected and appointed government officials have the right and obligation to acknowledge God as the foundation of American government

The cosmic snap parameter in f(R) gravity

We derive the expression for the snap parameter in f(R) gravity. We use the Palatini variational principle to obtain the field equations and regard the Einstein conformal frame as physical. We predict the present-day value of the snap parameter for the particular case f(R)=R-const/R, which is the simplest f(R) model explaining the current acceleration of the universe.Comment: 9 pages; published versio

Acceleration of the universe in the Einstein frame of a metric-affine f(R) gravity

We show that inflation and current cosmic acceleration can be generated by a metric-affine f(R) gravity formulated in the Einstein conformal frame, if the gravitational Lagrangian L(R) contains both positive and negative powers of the curvature scalar R. In this frame, we give the equations for the expansion of the homogeneous and isotropic matter-dominated universe in the case L(R)=R+{R^3}/{\beta^2}-{\alpha^2}/{3R}, where \alpha and \beta are constants. We also show that gravitational effects of matter in such a universe at very late stages of its expansion are weakened by a factor that tends to 3/4, and the energy density of matter \epsilon scales the same way as in the \Lambda-CDM model only when \kappa*\epsilon<<\alpha.Comment: 12 pages; published versio

Consistent modified gravity: dark energy, acceleration and the absence of cosmic doomsday

We discuss the modified gravity which includes negative and positive powers of the curvature and which provides the gravitational dark energy. It is shown that in GR plus the term containing negative power of the curvature the cosmic speed-up may be achieved, while the effective phantom phase (with $w$ less than -1) follows when such term contains the fractional positive power of the curvature. The minimal coupling with matter makes the situation more interesting: even 1/R theory coupled with the usual ideal fliud may describe the (effective phantom) dark energy. The account of $R^2$ term (consistent modified gravity) may help to escape of cosmic doomsday.Comment: LaTeX file, 9 pages, based on the talk given by S.D. Odintsov (Int. Conference Mathematical Methods in Physics, Rio de Janeiro, Augest, 2004), to appear in CQG, Letter

Cosmological perturbations in Palatini modified gravity

Two approaches to the study of cosmological density perturbations in modified theories of Palatini gravity have recently been discussed. These utilise, respectively, a generalisation of Birkhoff's theorem and a direct linearization of the gravitational field equations. In this paper these approaches are compared and contrasted. The general form of the gravitational lagrangian for which the two frameworks yield identical results in the long-wavelength limit is derived. This class of models includes the case where the lagrangian is a power-law of the Ricci curvature scalar. The evolution of density perturbations in theories of the type $f(R)=R-c /R^ b$ is investigated numerically. It is found that the results obtained by the two methods are in good agreement on sufficiently large scales when the values of the parameters (b,c) are consistent with current observational constraints. However, this agreement becomes progressively poorer for models that differ significantly from the standard concordance model and as smaller scales are considered

The HERMIT in the machine: a plugin for the interactive transformation of GHC core language programs

The importance of reasoning about and refactoring programs is a central tenet of functional programming. Yet our compilers and development toolchains only provide rudimentary support for these tasks. This paper introduces a programmatic and compiler-centric interface that facilitates refactoring and equational reasoning. To develop our ideas, we have implemented HERMIT, a toolkit enabling informal but systematic transformation of Haskell programs from inside the Glasgow Haskell Compiler’s optimization pipeline. With HERMIT, users can experiment with optimizations and equational reasoning, while the tedious heavy lifting of performing the actual transformations is done for them. HERMIT provides a transformation API that can be used to build higher-level rewrite tools. One use-case is prototyping new optimizations as clients of this API before being committed to the GHC toolchain. We describe a HERMIT application - a read-eval-print shell for performing transformations using HERMIT. We also demonstrate using this shell to prototype an optimization on a specific example, and report our initial experiences and remaining challenges

One-loop f(R) gravity in de Sitter universe

Motivated by the dark energy issue, the one-loop quantization approach for a family of relativistic cosmological theories is discussed in some detail. Specifically, general $f(R)$ gravity at the one-loop level in a de Sitter universe is investigated, extending a similar program developed for the case of pure Einstein gravity. Using generalized zeta regularization, the one-loop effective action is explicitly obtained off-shell, what allows to study in detail the possibility of (de)stabilization of the de Sitter background by quantum effects. The one-loop effective action maybe useful also for the study of constant curvature black hole nucleation rate and it provides the plausible way of resolving the cosmological constant problem.Comment: 25 pages, Latex file. Discussion enlarged, new references added. Version accepted in JCA

Genome-Scale Identification Method Applied to Find Cryptic Aminoglycoside Resistance Genes in Pseudomonas aeruginosa

BACKGROUND:The ability of bacteria to rapidly evolve resistance to antibiotics is a critical public health problem. Resistance leads to increased disease severity and death rates, as well as imposes pressure towards the discovery and development of new antibiotic therapies. Improving understanding of the evolution and genetic basis of resistance is a fundamental goal in the field of microbiology. RESULTS:We have applied a new genomic method, Scalar Analysis of Library Enrichments (SCALEs), to identify genomic regions that, given increased copy number, may lead to aminoglycoside resistance in Pseudomonas aeruginosa at the genome scale. We report the result of selections on highly representative genomic libraries for three different aminoglycoside antibiotics (amikacin, gentamicin, and tobramycin). At the genome-scale, we show significant (p<0.05) overlap in genes identified for each aminoglycoside evaluated. Among the genomic segments identified, we confirmed increased resistance associated with an increased copy number of several genomic regions, including the ORF of PA5471, recently implicated in MexXY efflux pump related aminoglycoside resistance, PA4943-PA4946 (encoding a probable GTP-binding protein, a predicted host factor I protein, a delta 2-isopentenylpyrophosphate transferase, and DNA mismatch repair protein mutL), PA0960-PA0963 (encoding hypothetical proteins, a probable cold shock protein, a probable DNA-binding stress protein, and aspartyl-tRNA synthetase), a segment of PA4967 (encoding a topoisomerase IV subunit B), as well as a chimeric clone containing two inserts including the ORFs PA0547 and PA2326 (encoding a probable transcriptional regulator and a probable hypothetical protein, respectively). CONCLUSIONS:The studies reported here demonstrate the application of new a genomic method, SCALEs, which can be used to improve understanding of the evolution of antibiotic resistance in P. aeruginosa. In our demonstration studies, we identified a significant number of genomic regions that increased resistance to multiple aminoglycosides. We identified genetic regions that include open reading frames that encode for products from many functional categories, including genes related to O-antigen synthesis, DNA repair, and transcriptional and translational processes

The phase space view of f(R) gravity

We study the geometry of the phase space of spatially flat Friedmann-Lemaitre-Robertson-Walker models in f(R) gravity, for a general form of the function f(R). The equilibrium points (de Sitter spaces) and their stability are discussed, and a comparison is made with the phase space of the equivalent scalar-tensor theory. New effective Lagrangians and Hamiltonians are also presented.Comment: 14 pages, 2 figures, published in Classical and Quantum Gravity; references adde

Antimicrobial resistance (AMR) nanomachines: mechanisms for fluoroquinolone and glycopeptide recognition, efflux and/or deactivation

In this review, we discuss mechanisms of resistance identified in bacterial agents Staphylococcus aureus and the enterococci towards two priority classes of antibiotics—the fluoroquinolones and the glycopeptides. Members of both classes interact with a number of components in the cells of these bacteria, so the cellular targets are also considered. Fluoroquinolone resistance mechanisms include efflux pumps (MepA, NorA, NorB, NorC, MdeA, LmrS or SdrM in S. aureus and EfmA or EfrAB in the enterococci) for removal of fluoroquinolone from the intracellular environment of bacterial cells and/or protection of the gyrase and topoisomerase IV target sites in Enterococcus faecalis by Qnr-like proteins. Expression of efflux systems is regulated by GntR-like (S. aureus NorG), MarR-like (MgrA, MepR) regulators or a two-component signal transduction system (TCS) (S. aureus ArlSR). Resistance to the glycopeptide antibiotic teicoplanin occurs via efflux regulated by the TcaR regulator in S. aureus. Resistance to vancomycin occurs through modification of the D-Ala-D-Ala target in the cell wall peptidoglycan and removal of high affinity precursors, or by target protection via cell wall thickening. Of the six Van resistance types (VanA-E, VanG), the VanA resistance type is considered in this review, including its regulation by the VanSR TCS. We describe the recent application of biophysical approaches such as the hydrodynamic technique of analytical ultracentrifugation and circular dichroism spectroscopy to identify the possible molecular effector of the VanS receptor that activates expression of the Van resistance genes; both approaches demonstrated that vancomycin interacts with VanS, suggesting that vancomycin itself (or vancomycin with an accessory factor) may be an effector of vancomycin resistance. With 16 and 19 proteins or protein complexes involved in fluoroquinolone and glycopeptide resistances, respectively, and the complexities of bacterial sensing mechanisms that trigger and regulate a wide variety of possible resistance mechanisms, we propose that these antimicrobial resistance mechanisms might be considered complex ‘nanomachines’ that drive survival of bacterial cells in antibiotic environments