The Cell-Nucleus as a Possible Source of Cathodally Migrating Serum Creatine-Kinase

Journal URL: http://www.clinchem.org

Serum creatine kinase B subunit levels in neurogenic atrophies

This study is an attempt to determine the creatine kinase B (CK-B) subunit levels in neurogenic atrophies. A group of 69 patients was studied and the results were compared with those in a group of 32 patients with muscle disease. The results showed that the CK-B levels are considerably higher in patients with amyotrophic lateral sclerosis (P<0.001) and peroneal muscular atrophy (P<0.001). Further studies in the various subgroups of neurogenic atrophies showed that, regardless of the nosological entity, the CK-B activity is considerably higher: (1) in the "widespread" as opposed to "limited" forms (P<0.001); (2) in the "chronic" than in the "acute" neurogenic atrophies (P<0.001); and (3) in the "active" as opposed to "residual" forms (P<0.02). It is suggested that the increase of CK-B in neurogenic atrophies is a strong indication of an active regeneration process in the denervated muscle. © 1985 Springer-Verlag

Macro-Creatine Kinase-BB: Observations on 6 Patients

Peer Reviewe