1,023 research outputs found
Proper Motions of H-alpha filaments in the Supernova Remnant RCW 86
We present a proper motion study of the eastern shock-region of the supernova
remnant RCW 86 (MSH 14-63, G315.4-2.3), based on optical observations carried
out with VLT/FORS2 in 2007 and 2010. For both the northeastern and southeastern
regions, we measure an average proper motion of H-alpha filaments of 0.10 +/-
0.02 arcsec/yr, corresponding to 1200 +/- 200 km/s at 2.5kpc. There is
substantial variation in the derived proper motions, indicating shock
velocities ranging from just below 700 km/s to above 2200 km/s.
The optical proper motion is lower than the previously measured X-ray proper
motion of northeastern region. The new measurements are consistent with the
previously measured proton temperature of 2.3 +/- 0.3 keV, assuming no
cosmic-ray acceleration. However, within the uncertainties, moderately
efficient (< 27 per cent) shock acceleration is still possible. The combination
of optical proper motion and proton temperature rule out the possibility that
RCW 86 has a distance less than 1.5kpc.
The similarity of the proper motions in the northeast and southeast is
peculiar, given the different densities and X-ray emission properties of the
regions. The northeastern region has lower densities and the X-ray emission is
synchrotron dominated, suggesting that the shock velocities should be higher
than in the southeastern, thermal X-ray dominated, region. A possible solution
is that the H-alpha emitting filaments are biased toward denser regions, with
lower shock velocities. Alternatively, in the northeast the shock velocity may
have decreased rapidly during the past 200yr, and the X-ray synchrotron
emission is an afterglow from a period when the shock velocity was higher.Comment: Accepted for publication in MNRA
Recent advances in the molecular understanding of glioblastoma
Glioblastoma is the most common and most aggressive primary brain tumor. Despite maximum treatment, patients only have a median survival time of 15 months, because of the tumor’s resistance to current therapeutic approaches. Thus far, methylation of the O6-methylguanine-DNA methyltransferase (MGMT) promoter has been the only confirmed molecular predictive factor in glioblastoma. Novel “genome-wide” techniques have identified additional important molecular alterations as mutations in isocitrate dehydrogenase 1 (IDH1) and its prognostic importance. This review summarizes findings and techniques of genetic, epigenetic, transcriptional, and proteomic studies of glioblastoma. It provides the clinician with an up-to-date overview of current identified molecular alterations that should ultimately lead to new therapeutic targets and more individualized treatment approaches in glioblastoma
Measuring the cosmic ray acceleration efficiency of a supernova remnant
Cosmic rays are the most energetic particles arriving at earth. Although most
of them are thought to be accelerated by supernova remnants, the details of the
acceleration process and its efficiency are not well determined. Here we show
that the pressure induced by cosmic rays exceeds the thermal pressure behind
the northeast shock of the supernova remnant RCW 86, where the X-ray emission
is dominated by synchrotron radiation from ultra-relativistic electrons. We
determined the cosmic-ray content from the thermal Doppler broadening measured
with optical spectroscopy, combined with a proper-motion study in X- rays. The
measured post-shock proton temperature in combination with the shock velocity
does not agree with standard shock heating, implying that >50% of the
post-shock pressure is produced by cosmic rays.Comment: Published in Science express, 10 pages, 5 figures and 2 table
Bispectral Index Changes during Acute Brainstem TIA/Ischemia
We describe a 76-year-old patient who suffered a brainstem TIA just before being anesthetised for cardiac surgery. The TIA was registered on BIS and resulted in a drop in BIS to a value of 60. When consciousness returned spontaneously, the BIS increased to 85. The relative use of the BIS during an operation is discussed. We believe that the lack of input from the brainstem to the frontal cortex resulted in the reduced cortical electrical activity as registered with the BIS
The Radial Structure of the Cygnus Loop Supernova Remnant --- Possible evidence of a cavity explosion ---
We observed the North-East (NE) Limb toward the center region of the Cygnus
Loop with the ASCA Observatory. We found a radial variation of electron
temperature (kTe) and ionization timescale (log(\tau)) whereas no variation
could be found for the abundances of heavy elements. In this paper, we
re-analyzed the same data set and new observations with the latest calibration
files. Then we constructed the precise spatial variations of kTe, log(\tau),
and abundances of O, Ne, Mg, Si, and Fe over the field of view (FOV). We found
a spatial variation not only in kTe and in log(\tau) but also in most of heavy
elements. As described in Miyata et al. (1994), values of kTe increase and
those of log(\tau) decrease toward the inner region. We found that the
abundance of heavy elements increases toward the inner region. The radial
profiles of O, Ne, and Fe show clear jump structures at a radius of 0.9 Rs,
where Rs is the shock radius. Outside of 0.9 Rs, abundances of all elements are
constant. On the contrary, inside of 0.9 Rs, abundances of these elements are
20--30 % larger than those obtained outside of 0.9 Rs. The radial profile of
kTe also shows the jump structure at 0.9 Rs. This means that the hot and metal
rich plasma fills the volume inside of 0.9 Rs. We concluded that this jump
structure was the possible evidence for the pre-existing cavity produced by the
precursor. If the ejecta fills inside of 0.9 Rs, the total mass of the ejecta
was roughly 4\Msun. We then estimated the main-sequence mass to be roughly
15\Msun, which supports the massive star in origin of the Cygnus Loop supernova
remnant and the existence of a pre-existing cavity.Comment: 37 pages, 14 figures. Accepted for publication of Ap
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Needs and opportunities in mineral evolution research
Progress in understanding mineral evolution, Earth’s changing near-surface mineralogy through time, depends on the availability of detailed information on mineral localities of known ages and geologic settings. A comprehensive database including this information, employing the mindat.org web site as a platform, is now being implemented. This resource will incorporate software to correlate a range of mineral occurrences and properties vs. time, and it will thus facilitate studies of the chang- ing diversity, distribution, associations, and characteristics of individual minerals as well as mineral groups. The Mineral Evolution Database thus holds the prospect of revealing mineralogical records of important geophysical, geochemical, and biological events in Earth history.Organismic and Evolutionary Biolog
Evaluation of pulmonary arterial hypertension: invasive or noninvasive?
Vascular Biology and Interventio
Cosmic ray diffusion near the Bohm limit in the Cassiopeia A supernova remnant
Supernova remnants (SNRs) are believed to be the primary location of the
acceleration of Galactic cosmic rays, via diffusive shock (Fermi) acceleration.
Despite considerable theoretical work the precise details are still unknown, in
part because of the difficulty in directly observing nucleons that are
accelerated to TeV energies in, and affect the structure of, the SNR shocks.
However, for the last ten years, X-ray observatories ASCA, and more recently
Chandra, XMM-Newton, and Suzaku have made it possible to image the synchrotron
emission at keV energies produced by cosmic-ray electrons accelerated in the
SNR shocks. In this article, we describe a spatially-resolved spectroscopic
analysis of Chandra observations of the Galactic SNR Cassiopeia A to map the
cutoff frequencies of electrons accelerated in the forward shock. We set upper
limits on the electron diffusion coefficient and find locations where particles
appear to be accelerated nearly as fast as theoretically possible (the Bohm
limit).Comment: 18 pages, 5 figures. Accepted for publication in Nature Physics (DOI
below), final version available week of August 28, 2006 at
http://www.nature.com/nphy
Non-Invasive Visualization of the Cardiac Venous System in Coronary Artery Disease Patients Using 64-Slice Computed Tomography
ObjectivesThis study was designed to evaluate the value of 64-slice computed tomography (CT) to visualize the cardiac veins and evaluate the relation between variations in venous anatomy and history of infarction.BackgroundCardiac resynchronization therapy (CRT) is an attractive treatment for selected heart failure patients. Knowledge of venous anatomy may help in identifying candidates for successful left ventricular lead implantation.MethodsThe 64-slice CT of 100 individuals (age 61 ± 11 years, 68% men) was studied. Subjects were divided into 3 groups: 28 control patients, 38 patients with significant coronary artery disease (CAD), and 34 patients with a history of infarction. Presence of the following coronary sinus (CS) tributaries was evaluated: posterior interventricular vein (PIV), posterior vein of the left ventricle, and left marginal vein (LMV). Vessel diameters were also measured.ResultsCoronary sinus and PIV were identified in all individuals. Posterior vein of the left ventricle was observed in 96% of control patients, 84% of CAD patients, and 82% of infarction patients. In patients with a history of infarction, a LMV was significantly less observed as compared with control patients and CAD patients (27% vs. 71% and 61%, respectively, p < 0.001). None of the patients with lateral infarction and only 22% of patients with anterior infarction had a LMV. Regarding quantitative data, no significant differences were observed between the groups.ConclusionsNon-invasive evaluation of cardiac veins with 64-slice CT is feasible. There is considerable variation in venous anatomy. Patients with a history of infarction were less likely to have a LMV, which may hamper optimal left ventricular lead positioning in CRT implantation
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