22,025 research outputs found
A Preliminary List of the Elateridea of Iowa
The Elateridae, or click beetles as they are commonly called, constitute a comparatively large family. Leng\u27s catalog lists over 600 species for North America, north of Mexico. While a few of our adult Elaterids reach the length of nearly two inches, the majority of our common species would range around l/2 inch in length, and occasionally species are not over 1/10 inch long. They are elongate in form, tapering more or less at each end, thus somewhat resembling the Buprestidae but are more loosely jointed between the thorax and abdomen. Many are dull brown or blackish in color, and are covered with a fine pubescence. They are found beneath bark, logs, stones, at the roots and on the foliage of various plants. The elasticity of the Elateridae gives the members of this family the power to leap into the air when placed on their backs. The actual movement is directly due to these facts: first, the prosternum is prolonged into a spine which extends into a groove in the mesosternum; and second, there is a loose articulation between the prothorax and the mesothorax so that the former can freely move up and down. As a preparation for the leap, the beetle bends its body so as to bring the prosternal spine nearly out of the groove in the mesosternum. Then by relaxing the muscles, the body straightens and allows the prosternal spine to be forcefully plunged back into the groove. This violent blow given to the mesothorax causes the base of the elytra to strike the supporting surface with force; thus the insect is hurled upward for several inches. The purpose of this interesting movement seems to be twofold: protection from enemies and to turn the beetle back on its feet
Cluster PEACE observations of electron pressure tensor divergence in the magnetotail
Cluster crossed the magnetotail neutral sheet on four occasions between 16: 38 and 16: 43 UT on 08/17/2003. The four-spacecraft capabilities of Cluster are used to determine spatial gradients from the magnetic field vectors and, for the first time, full electron pressure tensors. We find that the contribution to the electric field from the Hall term (max of similar to 6 mV/m) pointed towards the neutral sheet, whereas that from the electron pressure divergence ( max of similar to 1 mV/m) pointed away from the neutral sheet. The electric field contributions in this direction were closely anti-correlated. During this period Clusters 1 and 4 were sometimes above and below the neutral sheet respectively. This allowed the simultaneous observation of magnetic fields that are interpreted as two quadrants of the Hall magnetic field system. An associated field-aligned current system was detected using the curlometer and moments of the particle distributions
Digital computer simulation of inductor-energy-storage dc-to-dc converters with closed-loop regulators
The simulation of converter-controller combinations by means of a flexible digital computer program which produces output to a graphic display is discussed. The procedure is an alternative to mathematical analysis of converter systems. The types of computer programming involved in the simulation are described. Schematic diagrams, state equations, and output equations are displayed for four basic forms of inductor-energy-storage dc to dc converters. Mathematical models are developed to show the relationship of the parameters
Post-operative immune suppression is reversible with interferon gamma and independent of IL-6 pathways
Introduction
The post-operative period is characterised by increased IL-6 production and clinical features of immune suppression. In vitro anti-inflammatory actions of IL-6 are mediated through suppression of interferon gamma (IFNγ) [1]. The clinical significance of IL-6 in mediating post-operative immune suppression remains unclear.
Objectives
To evaluate the role of IL-6 pathways in post-operative immune suppression and the reversibility of this phenomenon.
Methods
Patients over 45 years old undergoing elective surgery involving the gastrointestinal tract and requiring at least an overnight hospital stay were recruited. The primary outcome was hospital-acquired infection. IL-6 and IFNγ levels were assayed using ELISA preoperatively and at 24 and 48 hours. Pooled healthy control peripheral blood mononuclear cells (PBMCs) were cultured in perioperative serum and CD14+HLA-DR (mHLA-DR) geometric mean florescent intensity (MFI) measured in the presence and absence of interferon gamma (IFNγ) and IL-6 neutralising antibody. Data were analysed with non-parametric statistics.
Results
119 patients were recruited and 44 (37%) developed a post-operative infection a median of 9 (IQR 5-11) days postoperatively (Figure 1). IL-6 levels increased from baseline to 24 hours postoperatively (P < 0.0001, Figure 1A) but were then unchanged between 24 and 48 hours (P = 0.06, Figure 1B). Postoperative IL-6 levels correlated with the duration of the procedure (P = 0.009). Higher preoperative IL-6 levels were observed in patients with cancer (P = 0.02). IL-6 levels at 24 (P = 0.0002) and 48 hours (P = 0.003) were associated with the later occurrence of infectious complications. This pattern remained similar after adjustment for baseline characteristics. Healthy donor PBMCs incubated with postoperative serum downregulated mHLA-DR MFI when compared with serum from baseline (n = 8, p = 0.008). Culturing in the presence of IFNγ 250IU (n = 4) prevented this decrease whereas culturing in the presence of IL-6 neutralising antibody 15ng/ml (n = 8) did not.
Conclusions
IL-6 levels increase following major surgery and are associated with an increased susceptibility to post-operative infections. Serum obtained from post-operative patients induces an immunosuppressive response through an IL-6 independent pathways which is reversible with IFNγ treatment
Optimal randomized multilevel algorithms for infinite-dimensional integration on function spaces with ANOVA-type decomposition
In this paper, we consider the infinite-dimensional integration problem on
weighted reproducing kernel Hilbert spaces with norms induced by an underlying
function space decomposition of ANOVA-type. The weights model the relative
importance of different groups of variables. We present new randomized
multilevel algorithms to tackle this integration problem and prove upper bounds
for their randomized error. Furthermore, we provide in this setting the first
non-trivial lower error bounds for general randomized algorithms, which, in
particular, may be adaptive or non-linear. These lower bounds show that our
multilevel algorithms are optimal. Our analysis refines and extends the
analysis provided in [F. J. Hickernell, T. M\"uller-Gronbach, B. Niu, K.
Ritter, J. Complexity 26 (2010), 229-254], and our error bounds improve
substantially on the error bounds presented there. As an illustrative example,
we discuss the unanchored Sobolev space and employ randomized quasi-Monte Carlo
multilevel algorithms based on scrambled polynomial lattice rules.Comment: 31 pages, 0 figure
Global monopoles in dilaton gravity
We analyse the gravitational field of a global monopole within the context of
low energy string gravity, allowing for an arbitrary coupling of the monopole
fields to the dilaton. Both massive and massless dilatons are considered. We
find that, for a massless dilaton, the spacetime is generically singular,
whereas when the dilaton is massive, the monopole generically induces a long
range dilaton cloud. We compare and contrast these results with the literature.Comment: 15 pages, 3 figures, version to appear in Class Quant Gra
A digital computer simulation and study of a direct-energy-transfer power-conditioning system
A digital computer simulation technique, which can be used to study such composite power-conditioning systems, was applied to a spacecraft direct-energy-transfer power-processing system. The results obtained duplicate actual system performance with considerable accuracy. The validity of the approach and its usefulness in studying various aspects of system performance such as steady-state characteristics and transient responses to severely varying operating conditions are demonstrated experimentally
Mathematical analysis of a model for the growth of the bovine corpus luteum
The corpus luteum (CL) is an ovarian tissue that grows in the wound space created by follicular rupture. It produces the progesterone needed in the uterus to maintain pregnancy. Rapid growth of the CL and progesterone transport to the uterus require angiogenesis, the creation of new blood vessels from pre-existing ones, a process which is regulated by proteins that include fibroblast growth factor 2 (FGF2).\ud
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In this paper we develop a system of time-dependent ordinary differential equations to model CL growth. The dependent variables represent FGF2, endothelial cells (ECs), luteal cells, and stromal cells (like pericytes), by assuming that the CL volume is a continuum of the three cell types. We assume that if the CL volume exceeds that of the ovulated follicle, then growth is inhibited. This threshold volume partitions the system dynamics into two regimes, so that the model may be classified as a Filippov (piecewise smooth) system.\ud
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We show that normal CL growth requires an appropriate balance between the growth rates of luteal and stromal cells. We investigate how angiogenesis influences CL growth by considering how the system dynamics depend on the dimensionless EC proliferation rate, p5. We find that weak (low p5) or strong (high p5) angiogenesis leads to ‘pathological’ CL growth, since the loss of CL constituents compromises progesterone production or delivery. However, for intermediate values of p5, normal CL growth is predicted. The implications of these results for cow fertility are also discussed. For example, inadequate angiogenesis has been linked to infertility in dairy cows
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