Cosmological constant in SUGRA models and the multiple point principle

The tiny order of magnitude of the cosmological constant is sought to be explained in a model involving the following ingredients: supersymmetry breaking in N=1 supergravity and the multiple point principle. We demonstrate the viability of this scenario in the minimal SUGRA model.Comment: 18 pages, 2 figures, Talk given at Nuclear Physics Department of the Russian Academy of Sciences (RAS) Conference on Physics of Fundamental Interactions, Moscow, Russia, 2-6 Dec 2002; to appear in Phys.Atom.Nuc

Sensitive method for endotoxin determination in nanomedicinal product samples.

Aim: Nanomaterials and nanomedicinal products tend to interfere with various commonly used assays, including regulatory required endotoxin detection methods for medicines. We developed a method to quantify endotoxin levels that is compatible with nanomaterials and nanomedicinal products. Materials & methods: The method is based on measuring endotoxin indirectly via 3-hydroxylated fatty acids of lipid-A, using Ultra High Performance Liquid Chromatography coupled with mass spectrometry. The outcome was related to results of the commonly used Limulus Amebocyte Lysate method. Results: The ultra high performance liquid chromatography coupled with mass spectrometry method has clear advantages compared with other endotoxin determination assays; particularly the absence of nanospecific interference. Conclusion: The method is sensitive, straightforward and accurate in determining and quantifying endotoxin in nanomedicinal product samples

Distribution, Elimination and Toxicity of Silver Nanoparticles and Silver Ions in Rats after 28-day Oral Exposure

We report the results of a 28-day oral exposure study in rats, exposed t

Sensitive method for endotoxin determination in nanomedicinal product samples.

Aim: Nanomaterials and nanomedicinal products tend to interfere with various commonly used assays, including regulatory required endotoxin detection methods for medicines. We developed a method to quantify endotoxin levels that is compatible with nanomaterials and nanomedicinal products. Materials & methods: The method is based on measuring endotoxin indirectly via 3-hydroxylated fatty acids of lipid-A, using Ultra High Performance Liquid Chromatography coupled with mass spectrometry. The outcome was related to results of the commonly used Limulus Amebocyte Lysate method. Results: The ultra high performance liquid chromatography coupled with mass spectrometry method has clear advantages compared with other endotoxin determination assays; particularly the absence of nanospecific interference. Conclusion: The method is sensitive, straightforward and accurate in determining and quantifying endotoxin in nanomedicinal product samples