948 research outputs found
Biomedical applications of aerospace-generated technology Quarterly report, 1 Sep. - 30 Nov. 1968
Biomedical applications of aerospace generated technolog
Management Misperceptions: An Obstacle to Motivation
Managers and supervisors create a motivational environment by being responsive to the needs and wants of employees. However, managers have many misconceptions about what workers want from their jobs. The author discusses how to create the best organizational environment
Biomedical applications of aerospace- generated technology Quarterly report, 1 Dec. 1968 - 28 Feb. 1969
Biomedical applications team for transferring aerospace generated technology to nonaerospace biomedical fiel
Local Anisotropy of Fluids using Minkowski Tensors
Statistics of the free volume available to individual particles have
previously been studied for simple and complex fluids, granular matter,
amorphous solids, and structural glasses. Minkowski tensors provide a set of
shape measures that are based on strong mathematical theorems and easily
computed for polygonal and polyhedral bodies such as free volume cells (Voronoi
cells). They characterize the local structure beyond the two-point correlation
function and are suitable to define indices of
local anisotropy. Here, we analyze the statistics of Minkowski tensors for
configurations of simple liquid models, including the ideal gas (Poisson point
process), the hard disks and hard spheres ensemble, and the Lennard-Jones
fluid. We show that Minkowski tensors provide a robust characterization of
local anisotropy, which ranges from for vapor
phases to for ordered solids. We find that for fluids,
local anisotropy decreases monotonously with increasing free volume and
randomness of particle positions. Furthermore, the local anisotropy indices
are sensitive to structural transitions in these simple
fluids, as has been previously shown in granular systems for the transition
from loose to jammed bead packs
Reduction of myocardial infarction by postischemic administration of the calpain inhibitor A-705253 in comparison to the Na(+)/H(+) exchange inhibitor Cariporide (R) in isolated perfused rabbit hearts
The calpain inhibitor A-705253 and the Na(+)/H(+) exchange inhibitor Cariporide (R) were studied in isolated perfused rabbit hearts subjected to 60 min occlusion of the ramus interventricularis of the left coronary artery (below the origin of the first diagonal branch), followed by 120 min of reperfusion. The inhibitors were added to the perfusion fluid solely or in combination at the beginning of reperfusion. Hemodynamic monitoring and biochemical analysis of perfusion fluid from the coronary outflow were performed. Myocardial infarct size and area at risk (transiently not perfused myocardium) were determined from left ventricular slices after a special staining procedure with Evans blue and 2,3,5-triphenyltetrazolium chloride. The infarcted area (dead myocardium) was 72.7 +/- 4.0% of the area at risk in untreated controls, but was significantly smaller in the presence of the inhibitors. The largest effect was observed with 10(-6) M A-705253, which reduced the infarcted area to 49.2 +/- 4.1% of the area at risk, corresponding to a reduction of 33.6%. Cariporide (R) at 10(-6) M reduced the infarct size to the same extent. The combination of both inhibitors, however, did not further improve cardioprotection. No significant difference was observed between the experimental groups in coronary perfusion, left ventricular pressure, heart rate, or in the release of lactate dehydrogenase and creatine kinase from heart muscle
Exploring Transcriptional Silencing of Transposons in Zebrafish
DNA methylation plays a critical role as an epigenetic
modifier in plants and mammals, however it is absent from many
invertebrate
genomes. Although DNA methylation is known to be present in zebrafish,
there is limited research on its function. In plants and mammals, one
critical function of DNA methylation is the repression of transposable
elements, parasitic elements that can be detrimental to the host
genome. While it is known that transposons are present in the
zebrafish genome, it is unknown whether their expression is dependent
on methylation.
I examined expression of two transposons, dirs and bhikhari, in wild
type embryos and in embryos with hypomethylated genomes.
Preliminary data show the unexpected result that expression of some
transposons is not regulated by DNA methylation in the zebrafish
larva.Johns Hopkins University, Office of the Provos
Nonmonotonic Decay of Nonequilibrium Polariton Condensate in Direct-Gap Semiconductors
Time evolution of a nonequilibrium polariton condensate has been studied in
the framework of a microscopic approach. It has been shown that due to
polariton-polariton scattering a significant condensate depletion takes place
in a comparatively short time interval. The condensate decay occurs in the form
of multiple echo signals. Distribution-function dynamics of noncondensate
polaritons have been investigated. It has been shown that at the initial stage
of evolution the distribution function has the form of a bell. Then
oscillations arise in the contour of the distribution function, which further
transform into small chaotic ripples. The appearance of a short-wavelength wing
of the distribution function has been demonstrated. We have pointed out the
enhancement and then partial extinction of the sharp extra peak arising within
the time interval characterized by small values of polariton condensate density
and its relatively slow changes.Comment: 20 pages, LaTeX 2.09; in press in PR
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