Experimental study and evaluation of radioprotective drugs

Experimental study evaluates radioprotective drugs administered before exposure either orally or intravenously. Specifically studied are the sources of radiation, choice of radiation dose, choice of animals, administration of drugs, the toxicity of protective agents and types of protective drug

Charge Distribution Near Oxygen Vacancies in Reduced Ceria

Understanding the electronic charge distribution around oxygen vacancies in transition metal and rare earth oxides is a scientific challenge of considerable technological importance. We show how significant information about the charge distribution around vacancies in cerium oxide can be gained from a study of high resolution crystal structures of higher order oxides which exhibit ordering of oxygen vacancies. Specifically, we consider the implications of a bond valence sum analysis of Ce$_{7}$O$_{12}$ and Ce$_{11}$O$_{20}$. To illuminate our analysis we show alternative representations of the crystal structures in terms of orderly arrays of co-ordination defects and in terms of flourite-type modules. We found that in Ce$_{7}$O$_{12}$, the excess charge resulting from removal of an oxygen atom delocalizes among all three triclinic Ce sites closest to the O vacancy. In Ce$_{11}$O$_{20}$, the charge localizes on the next nearest neighbour Ce atoms. Our main result is that the charge prefers to distribute itself so that it is farthest away from the O vacancies. This contradicts \emph{the standard picture of charge localisation} which assumes that each of the two excess electrons localises on one of the cerium ions nearest to the vacancy. This standard picture is assumed in most calculations based on density functional theory (DFT). Based on the known crystal structure of Pr$_{6}$O$_{11}$, we also predict that the charge in Ce$_{6}$O$_{11}$ will be found in the second coordination shell of the O vacancy. Although this review focuses on bulk cerium oxides our approach to characterising electronic properties of oxygen vacancies and the physical insights gained should also be relevant to surface defects and to other rare earth and transition metal oxides.Comment: 20 pages, 23 figures. The replacement file has a new format for the figures are the document layout but no change in content. v3 has the following main changes: 1. The abstract and introduction were extensively revised. 2. Sec. IV was removed. 3. The Conclusion was rewritte

Effects of residual fatigue on pace regulation during sprint-distance triathlon running

Introduction: It has been suggested that unique relationships exist between perceived exertion, pacing and physiological responses during triathlon. However, research to date has not clearly established how the interaction of these factors is affected by residual physiological fatigue, particularly during running performance over distances relevant to sprint-distance triathlon. This study therefore investigated the effects of the preceding swim and cycle on pacing strategy, perceived exertion, and physiological status during sprint-distance triathlon running. Methods: Eight amateur male triathletes (mean ± SD: age 36.0 ± 5.7 yrs, mass 75.7 ± 5.3 kg) completed two field-based performance trials. The first was a sprint-distance triathlon (0.75 km swim, 20 km cycle, 5 km run) and the second an isolated 5 km run time-trial, each separated by 7-18 days and utilising the same flat out-and-back road course. Wrist-mounted GPS devices (Garmin 310XT, UK) recorded performance time, running speed (km•h-1) and heart rate during each trial. Participants recorded ratings of perceived exertion (Borg 6-20 scale) every kilometre using a wrist-mounted recording sheet and pen. Core temperature (CorTemp, HQInc, USA), blood lactate concentration (Lactate Pro, Kodak, Japan) and body mass (to 0.1 kg; Seca 875) were also measured immediately prior to, and after, each run. Results: Performance time for isolated running (19:28 ± 00:32) was ~7% quicker than triathlon running (20:48 ± 00:43) (p<0.01), with a similar positive pacing strategy displayed throughout both trials (figure 1). Initial core temperature, blood lactate concentration and heart rate values were all significantly higher for the triathlon run compared to the isolated run (p<0.01), with no differences in final values for these measures. No significant differences were observed for initial RPE, rate of RPE increase, or final RPE between runs. Discussion/Conclusion: Prior swimming and cycling impair performance but do not affect pacing strategy during sprint-distance triathlon running. Reduced performance may be attributed to the residual physiological strain observed at the start of the triathlon run. However, the maintenance of scalar-linear increases in RPE appears to be the primary regulator of pacing strategy during triathlon running, with physiological responses only indirectly related to this process

Effect of plyometric training on swimming block start performance in adolescents

This study aimed to identify the effect of plyometric training (PT), when added to habitual training (HT) regimes, on swim start performance. After the completion of a baseline competitive swim start, 22 adolescent swimmers were randomly assigned to either a PT (n = 11, age: 13.1 ± 1.4 yr, mass: 50.6 ± 12.3 kg, stature: 162.9 ± 11.9 cm) or an HT group (n = 11, age: 12.6 ± 1.9 yr, mass: 43.3 ± 11.6 kg, stature: 157.6 ± 11.9 cm). Over an 8-week preseason period, the HT group continued with their normal training program, whereas the PT group added 2 additional 1-hour plyometric-specific sessions, incorporating prescribed exercises relating to the swimming block start (SBS). After completion of the training intervention, post-training swim start performance was reassessed. For both baseline and post-trials, swim performance was recorded using videography (50Hz Canon MVX460) in the sagital plane of motion. Through the use of Silicon Coach Pro analysis package, data revealed significantly greater change between baseline and post-trials for PT when compared with the HT group for swim performance time to 5.5 m (−0.59 s vs. −0.21 s; p < 0.01) and velocity of take-off to contact (0.19 ms−1 vs. −0.07 ms−1; p < 0.01). Considering the practical importance of a successful swim start to overall performance outcome, the current study has found that inclusion of suitable and safely implemented PT to adolescent performers, in addition to HT routines, can have a positive impact on swim start performance

Gravity flow rate of solids through orifices and pipes

Lock-hopper systems are the most common means for feeding solids to and from coal conversion reactor vessels. The rate at which crushed solids flow by gravity through the vertical pipes and valves in lock-hopper systems affects the size of pipes and valves needed to meet the solids-handling requirements of the coal conversion process. Methods used to predict flow rates are described and compared with experimental data. Preliminary indications are that solids-handling systems for coal conversion processes are over-designed by a factor of 2 or 3

Water vapor diffusion membranes, 2

Transport mechanisms were investigated for the three different types of water vapor diffusion membranes. Membranes representing porous wetting and porous nonwetting structures as well as dense diffusive membrane structures were investigated for water permeation rate as a function of: (1) temperature, (2) solids composition in solution, and (3) such hydrodynamic parameters as sweep gas flow rate, solution flow rate and cell geometry. These properties were measured using nitrogen sweep gas to collect the effluent. In addition, the chemical stability to chromic acid-stabilized urine was measured for several of each type of membrane. A technology based on the mechanism of vapor transport was developed, whereby the vapor diffusion rates and relative susceptibility of membranes to fouling and failure could be projected for long-term vapor recovery trials using natural chromic acid-stabilized urine

Remnants of an ancient metabolism without phosphate

Phosphate is essential for all living systems, serving as a building block of genetic and metabolic machinery. However, it is unclear how phosphate could have assumed these central roles on primordial Earth, given its poor geochemical accessibility. We used systems biology approaches to explore the alternative hypothesis that a protometabolism could have emerged prior to the incorporation of phosphate. Surprisingly, we identified a cryptic phosphate-independent core metabolism producible from simple prebiotic compounds. This network is predicted to support the biosynthesis of a broad category of key biomolecules. Its enrichment for enzymes utilizing iron-sulfur clusters, and the fact that thermodynamic bottlenecks are more readily overcome by thioester rather than phosphate couplings, suggest that this network may constitute a "metabolic fossil" of an early phosphate-free nonenzymatic biochemistry. Our results corroborate and expand previous proposals that a putative thioester-based metabolism could have predated the incorporation of phosphate and an RNA-based genetic system. PAPERCLIP

Decay estimates for variable coefficient wave equations in exterior domains

In this article we consider variable coefficient, time dependent wave equations in exterior domains. We prove localized energy estimates if the domain is star-shaped and global in time Strichartz estimates if the domain is strictly convex.Comment: 15 pages. In the new version, some typos are fixed and a minor correction was made to the proof of Lemma 1