Waiting for child developmental and rehabilitation services: an overview of issues and needs

Concern about the length of time that children, young people, and families may have to wait to access assessment, diagnostic, interventional, therapeutic, and supportive child developmental and rehabilitation (CDR) services is widespread, but adequate data collection and research on this issue remain limited. We review key concepts and issues relevant to waiting for CDR services from the published literature, a national workshop devoted to this topic, and international experience. We conclude that gaps in data, evidence, and consensus challenge our ability to address the issue of waiting for CDR services in a systematic way. A program of research coupled with actions based on consensus-building is required. Research priorities include acquiring evidence of the appropriateness and effectiveness of different models of intervention and rehabilitation services, and documenting the experience and expectations of waiting families. Consensus-building processes are critical to identify, categorize, and prioritize \u27sentinel\u27 components of CDR service pathways: (1) to reduce the inherent complexity of the field; (2) to create benchmarks for waiting for these respective services; and (3) to develop definitions for wait-time subcomponents in CDR services. Collection of accurate and replicable data on wait times for CDR services can be used to document baseline realities, to monitor and improve system performance, and to conduct comparative and analytic research in the field of CDR services

Human-computer interaction in intelligent tutoring systems

Due to the rapid evolution of society, citizens are constantly being pressured to obtain new skills through training. The need for qualified people has grown exponentially, which means that the resources for education/training are significantly more limited, so it's necessary to create systems that can solved this problem. The implementation of Intelligent Tutoring Systems (ITS) can be one solution. Besides, ITS aims to enable users to acquire knowledge and develop skills in a specific field. To achieve this goal, the ITS should learn how to react to the actions and needs of the users, and this should be achieved in a non-intrusive and transparent way. In order to provide personalized and adapted system, it is necessary to know the preferences and habits of users. Thus, the ability to learn patterns of behaviour becomes an essential aspect for the successful implementation of an ITS. In this article, we present the student model of an ITS, in order to monitor the user's biometric behaviour and their learning style during e-learning activities. In addition, a machine learning categorization model is presented that oversees student activity during the session. Additionally, this article highlights the main biometric behavioural variations for each activity, making these attributes enable the development of machine learning classifiers to predict users' learning preferences. These results can be instrumental in improving ITS systems in e-learning environments and predict user behaviour based on their interaction with computers or other devices.This work has been supported by FCT – Fundação para a Ciência e Tecnologia within the Project Scope: UID/CEC/00319/2019

Candida albicans biofilm heterogeneity does not influence denture stomatitis but strongly influences denture cleansing capacity

Approximately 20  % of the UK population wear some form of denture prosthesis, resulting in denture stomatitis in half of these individuals. Candida albicans is primarily attributed as the causative agent, due to its biofilm -forming ability. Recently, there has been increasing evidence of C. albicans biofilm heterogeneity and the negative impact it can have clinically; however, this phenomenon has yet to be studied in relation to denture isolates. The aims of this study were to evaluate C. albicans biofilm formation of clinical denture isolates in a denture environment and to assess antimicrobial activity of common denture cleansers against these tenacious communities. C. albicans isolated from dentures of healthy and diseased individuals was quantified using real-time PCR and biofilm biomass assessed using crystal violet. Biofilm development on the denture substratum poly(methyl methacrylate), Molloplast B and Ufi-gel was determined. Biofilm formation was assessed using metabolic and biomass stains, following treatment with denture hygiene products. Although C. albicans was detected in greater quantities in diseased individuals, it was not associated with increased biofilm biomass. Denture substrata were shown to influence biofilm biomass, with poly(methyl methacrylate) providing the most suitable environment for C. albicans to reside. Of all denture hygiene products tested, Milton had the most effective antimicrobial activity, reducing biofilm biomass and viability the greatest. Overall, our results highlight the complex nature of denture- related disease, and disease development cannot always be attributed to a sole cause. It is the distinct combination of various factors that ultimately determines the pathogenic outcome

The exclusive \bar{B} --> \pi e^+ e^- and \bar{B} --> \rho e^+ e^- decays in the two Higgs doublet model with flavor changing neutral currents

We calculate the leading logarithmic QCD corrections to the matrix element of the decay b --> d e^+ e^- in the two Higgs doublet model with tree level flavor changing currents (model III). We continue studying the differential branching ratio and the CP violating asymmetry for the exclusive decays B --> \pi e^+ e^- and B --> \rho e^+ e^- and analysing the dependencies of these quantities on the selected model III parameters, \xi^{U,D}, including the leading logarithmic QCD corrections. Further, we present the forward-backward asymmetry of dileptons for the decay B --> \rho e^+ e^- and discuss the dependencies to the model III parameters. We observe that there is a possibility to enhance the branching ratios and suppress the CP violating effects for both decays in the framework of the model III. Therefore, the measurements of these quantities will be an efficient tool to search the new physics beyond the SM.Comment: 27 pages, 14 Figure

B -> K^* gamma from D -> K^* l nu

The B -> K^* gamma branching fraction is predicted using heavy quark spin symmetry at large recoil to relate the tensor and (axial-)vector form factors, using heavy quark flavor symmetry to relate the B decay form factors to the measured D -> K^* l nu form form factors, and extrapolating the semileptonic B decay form factors to large recoil assuming nearest pole dominance. This prediction agrees with data surprisingly well, and we comment on its implications for the extraction of |Vub| from B -> rho l nu.Comment: 10 page

Host circadian rhythms are disrupted during malaria infection in parasite genotype-specific manners

Infection can dramatically alter behavioural and physiological traits as hosts become sick and subsequently return to health. Such “sickness behaviours” include disrupted circadian rhythms in both locomotor activity and body temperature. Host sickness behaviours vary in pathogen species-specific manners but the influence of pathogen intraspecific variation is rarely studied. We examine how infection with the murine malaria parasite, Plasmodium chabaudi, shapes sickness in terms of parasite genotype-specific effects on host circadian rhythms. We reveal that circadian rhythms in host locomotor activity patterns and body temperature become differentially disrupted and in parasite genotype-specific manners. Locomotor activity and body temperature in combination provide more sensitive measures of health than commonly used virulence metrics for malaria (e.g. anaemia). Moreover, patterns of host disruption cannot be explained simply by variation in replication rate across parasite genotypes or the severity of anaemia each parasite genotype causes. It is well known that disruption to circadian rhythms is associated with non-infectious diseases, including cancer, type 2 diabetes, and obesity. Our results reveal that disruption of host circadian rhythms is a genetically variable virulence trait of pathogens with implications for host health and disease tolerance

Specifying computer-supported collaboration scripts

Collaboration scripts are activity programs which aim to foster collaborative learning by structuring interaction between learners. Computer-supported collaboration scripts generally suffer from the problem of being restrained to a specific learning platform and learning context. A standardization of collaboration scripts first requires a specification of collaboration scripts that integrates multiple perspectives from computer science, education and psychology. So far, only few and limited attempts at such specifications have been made. This paper aims to consolidate and expand these approaches in light of recent findings and to propose a generic framework for the specification of collaboration scripts. The framework enables a description of collaboration scripts using a small number of components (participants, activities, roles, resources and groups) and mechanisms (task distribution, group formation and sequencing)

Potential Models for Radiative Rare B Decays

We compute the branching ratios for the radiative rare decays of B into K-Meson states and compare them to the experimentally determined branching ratio for inclusive decay b -> s gamma using non relativistic quark model, and form factor definitions consistent with HQET covariant trace formalism. Such calculations necessarily involve a potential model. In order to test the sensitivity of calculations to potential models we have used three different potentials, namely linear potential, screening confining potential and heavy quark potential as it stands in QCD.We find the branching ratios relative to the inclusive b ->s gamma decay to be (16.07\pm 5.2)% for B -> K^* (892)gamma and (7.25\pm 3.2)% for B -> K_2^* (1430)gamma for linear potential. In the case of the screening confining potential these values are (19.75\pm 5.3)% and (4.74\pm 1.2)% while those for the heavy quark potential are (11.18\pm 4.6)% and (5.09\pm 2.7)% respectively. All these values are consistent with the corresponding present CLEO experimental values: (16.25\pm 1.21)% and (5.93\pm 0.46)%.Comment: RevTeX, 6 pages, 1 eps figur

Two New LBV Candidates in the M33 Galaxy

We present two new luminous blue variable (LBV) candidate stars discovered in the M33 galaxy. We identified these stars (Valeev et al. 2010) as massive star candidates at the final stages of evolution, presumably with a notable interstellar extinction. The candidates were selected from the Massey et al. (2006) catalog based on the following criteria: emission in Halpha, V<18.5 and 0.35<(B-V)<1.2. The spectra of both stars reveal a broad and strong Halpha emission with extended wings (770 and 1000 km/s). Based on the spectra we estimated the main parameters of the stars. Object N45901 has a bolometric luminosity log(L/Lsun)=6.0-6.2 with the value of interstellar extinction Av=2.3+-0.1. The temperature of the star's photosphere is estimated as Tstar~13000-15000K its probable mass on the Zero Age Main Sequence is M~60-80Msun. The infrared excess in N45901 corresponds to the emission of warm dust with the temperature Twarm~1000K, and amounts to 0.1% of the bolometric luminosity. A comparison of stellar magnitude estimates from different catalogs points to the probable variability of the object N45901. Bolometric luminosity of the second object, N125093, is log(L/Lsun)=6.3-6.6, the value of interstellar extinction is Av=2.75+-0.15. We estimate its photosphere's temperature as Tstar~13000-16000K, the initial mass as M~90-120Msun. The infrared excess in N125093 amounts to 5-6% of the bolometric luminosity. Its spectral energy distribution reveals two thermal components with the temperatures Twarm~1000K and Tcold~480K. The [CaII] lines (7291A and 7323A), observed in LBV-like stars VarA and N93351 in M33, are also present in the spectrum of N125093. These lines indicate relatively recent gas eruptions and dust activity linked with them. High bolometric luminosity of these stars and broad Halpha emissions allow classifying the studied objects as LBV candidates.Comment: 14 pages, 4 figure

CP Asymmetry of B→Xsl+l−B\to X_sl^+l^- in Low Invariant Mass Region

I analyzed the CP asymmetry of $B\to X_sl^+l^-$ based on model-independent analysis which includes twelve independent four Fermi operators. The CP asymmetry is suppressed in the Standard Model, however, if some new physics make it much larger, the present or the next generation B factories may catch the CP violation in this decay mode. In this paper, we studied the correlation of the asymmetry and the branching ratio, and then we will find only a type of interactions can be enlarge the asymmetry. Therefore, in comparison with experiments, we have possibility that we can constrain models beyond the standard model.Comment: 12 pages, 5 figures, LaTeX, Accepted for Physical Review