Zonage climatique viticole et cartographie numérique du Rio Grande do Sul - Brésil, par les indices du Système CCM Géoviticole.

Abstract: The State Rio Grande do Sul is the main producer of Brazilian fine wines, with four viticultural regions. The objective is the characterization of the viticultural climatic potential of the State (total surface of 281.749 km2). The methodology use the Géoviticulture Multicriteria Climatic Classification System (Géoviticulture MCC System), based on three climatic indices ? Dryness Index (DI), Heliotermal Index (HI) and Cool Night Index (CI). Based on latitude, longitude, altitude and distance from Atlantic Ocean, the 3 viticultural climatic indices were modeled and the algorithms applied to a DTM using GIS. The results show that Rio Grande do Sul has the following classes of viticultural climate: according to DI ? Moderately Dry, Sub-humid, Humid; according to HI ? Cool, Temperate, Temperate warm, Warm and Very Warm; according to CI ? Cool nights, Temperate nights, Warm nights. Based on the total surface, the most representatives viticultural climates are: « Humid x Temperate » (3,1%), « Humid x Temperate warm » (14,4%), « Humid x Warm » (52,6%), « Sub-humid x Warm » (20,0%) and « Sub-humid x Very warm » (5,8%). According to CI, the viticultural climates have a range of variation as a function of the interaction between « earlyness of the varieties x heliothermal availability ». Key words: climate classification, climate models, climatic Groups, zonin

REPRESENTING INTANGIBLE CULTURAL HERITAGE OF HUMANITY: FROM THE DEEP ABYSS OF THE PAST TO DIGITAL TWIN AND XR OF THE NEANDERTHAL MAN AND LAMALUNGA CAVE (ALTAMURA, APULIA)

The Altamura Man and the paleontological remains are situated within a complex context encompassing logistical, geological, paleoenvironmental, and cultural perspectives. This context is exceptionally well-preserved but also fragile, requiring its preservation due to its unique nature. Unresolved inquiries exist in various disciplines, such as archaeology, biocultural studies, ecology, and geology, pertaining to karst formation, taphonomic dynamics, and the cultural and ecological context of the Neanderthal individual found in the cave. Interdisciplinary research was necessary to address these complex questions and understand the broader context of the Lamalunga Cave. Climate change also necessitated attention to preserving the cave’s microclimate and monitoring potential biodegradation. Digital technologies, including photogrammetry and laser scanning, were crucial for monitoring and safeguarding the cave’s cultural heritage. Digital representation, 3D modelling and Digital Twin were essential for managing the cave’s intricacies, analysing its values, and enhancing visual communication. The management of the Lamalunga cave aimed to promote scientific interpretation, safeguard the cave, and provide tools for understanding, storytelling, and further investigation. It was essential to utilise available methodologies and technologies while avoiding destructive interventions. Contemporary technologies have revolutionised the archaeological and paleoanthropological domains, enabling remote study and preservation. Protecting and comprehending the cultural heritage of the cave is linked to its usability, which can be enhanced through digital documentation methodologies to inform visitors about the karst context and promote social and economic development

Condições meteorológicas e sua influência na vindima de 2011 no Rio Grande do Sul.

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The spectrum of small-bowel lesions of AL-type amyloidosis at capsule endoscopy

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Full-arch intraoral scanning: comparison of two different strategies and their accuracy outcomes

Aim To test if there is a difference in accuracy between full-arch scans performed as two separate halves and stitched together, or as one continuous scan from side to side. Materials and Methods A reference model with six implants was milled as a single titanium block. Six scan bodies were manufactured and screwed into the implants. A reference 3D model was created using an industrial optical scanner. The experiment was performed using the same intraoral scanning machine (3M True Definition Scanner). The ‘Stitching’ strategy had the scan started from #27 to #13;after saving this part, the same procedure was performed from #17 to #23 and the software stitched the two halves automatically. The ‘No Stitching’ strategy had the scan performed as a single procedure. Using engineering software, six copies of the scan body CAD file were substituted to the six scan bodies of the RM and the centre point of each one was determined. Linear measurements were made between the detected points; mean distance and standard deviation were calculated for each of the fifteen measurement sets created. Results Stitching and No Stitching did not show statistically significant differences (Stitching=0.0396 mm ±0.0409 mm, No Stitching=0.0452 mm ±0,0481 mm, p=.338) but they differed significantly comparing absolute errors (Stitching=0.0442 mm ±0.0358 mm, No Stitching=0.0555 mm±0,036 mm, p=.015). Conclusions Stitching showed a better precision compared to No Stitching, exhibiting a smaller standard deviation and a higher error density closer to zero

O clima vitícola das regiões produtoras de uvas para vinhos finos do Brasil.

O Brasil está situado entre as latitudes 05°16'20" N e 33°44'42" S e longitudes 34°45'54"W e 73°59'32" W, possuindo uma grande variabilidade climática. Nele encontramos climas temperados, climas subtropicais e climas tropicais, incluindo climas equatoriais. A vitivinicultura de vinhos finos no Brasil é desenvolvida principalmente na Região Sul e na Região Nordeste do país. Na região Sul as regiões vitícolas estão localizadas nos Estados do Rio Grande do Sul e de Santa Catarina. Na região Nordeste, a vitivinicultura está localizada nos Estados de Pernambuco e Bahia

Sequential valproic acid/all-trans retinoic acid treatment reprograms differentiation in refractory and high risk acute myeloid leukemia.

Epigenetic alterations of chromatin due to aberrant histone deacetylase (HDAC) activity and transcriptional silencing of all-trans retinoic acid (ATRA) pathway are events linked to the pathogenesis of acute myeloid leukemia (AML) that can be targeted by specific treatments. A pilot study was carried out in eight refractory or high-risk AML patients not eligible for intensive therapy to assess the biological and therapeutic activities of the HDAC inhibitor valproic acid (VPA) used to remodel chromatin, followed by the addition of ATRA, to activate gene transcription and differentiation in leukemic cells. Hyperacetylation of histones H3 and H4 was detectable at therapeutic VPA serum levels (>or=50 microg/mL) in blood mononuclear cells from seven of eight patients. This correlated with myelomonocytic differentiation of leukemic cells as revealed by morphologic, cytochemical, immunophenotypic, and gene expression analyses. Differentiation of the leukemic clone was proven by fluorescence in situ hybridization analysis showing the cytogenetic lesion +8 or 7q- in differentiating cells. Hematologic improvement, according to established criteria for myelodysplastic syndromes, was observed in two cases. Stable disease and disease progression were observed in five and one cases, respectively. In conclusion, VPA-ATRA treatment is well tolerated and induces phenotypic changes of AML blasts through chromatin remodeling. Further studies are needed to evaluate whether VPA-ATRA treatment by reprogramming differentiation of the leukemic clone might improve the response to chemotherapy in leukemia patients

Multiple Integrated Non-clinical Studies Predict the Safety of Lentivirus-Mediated Gene Therapy for \u3b2-Thalassemia

Gene therapy clinical trials require rigorous non-clinical studies in the most relevant models to assess the benefit-to-risk ratio. To support the clinical development of gene therapy for \u3b2-thalassemia, we performed in vitro and in vivo studies for prediction of safety. First we developed newly GLOBE-derived vectors that were tested for their transcriptional activity and potential interference with the expression of surrounding genes. Because these vectors did not show significant advantages, GLOBE lentiviral vector (LV) was elected for further safety characterization. To support the use of hematopoietic stem cells (HSCs) transduced by GLOBE LV for the treatment of \u3b2-thalassemia, we conducted toxicology, tumorigenicity, and biodistribution studies in compliance with the OECD Principles of Good Laboratory Practice. We demonstrated a lack of toxicity and tumorigenic potential associated with GLOBE LV-transduced cells. Vector integration site (IS) studies demonstrated that both murine and human transduced HSCs retain self-renewal capacity and generate new blood cell progeny in the absence of clonal dominance. Moreover, IS analysis showed an absence of enrichment in cancer-related genes, and the genes targeted by GLOBE LV in human HSCs are well known sites of integration, as seen in other lentiviral gene therapy trials, and have not been associated with clonal expansion. Taken together, these integrated studies provide safety data supporting the clinical application of GLOBE-mediated gene therapy for \u3b2-thalassemia

Monte Belo: características da identidade regional para uma indicação geográfica de vinhos.

bitstream/CNPUV/9754/1/cir076.pdfDisponível também no formato online