440 research outputs found
A Change of Variables to the Dual and Factorization of Composite Anomalous Jacobians
Changes of variables giving the dual model are constructed explicitly for
sigma-models without isotropy. In particular, the jacobian is calculated to
give the known results. The global aspects of the abelian case as well as some
of those of the cases where the isometry group is simply connected are
considered.
Considering the anomalous case, we infer by a consistency argument that the
`multiplicative anomaly' should be replaceable by adequate rules for
factorization of composite jacobians. These rules are then generalized in a
simple way for composite jacobians defined in spaces of different types.
Implimentation of these rules then gives specific formulas for the anomally for
semisimple algebras and also for solvable ones.Comment: 15 pages, no figures, Latex file, A treatment of the global aspects
of the abelian and of semisimple duality groups are added. General formulas
for the mixed anomaly are derive
The Complexity of Reasoning for Fragments of Default Logic
Default logic was introduced by Reiter in 1980. In 1992, Gottlob classified
the complexity of the extension existence problem for propositional default
logic as \SigmaPtwo-complete, and the complexity of the credulous and
skeptical reasoning problem as SigmaP2-complete, resp. PiP2-complete.
Additionally, he investigated restrictions on the default rules, i.e.,
semi-normal default rules. Selman made in 1992 a similar approach with
disjunction-free and unary default rules. In this paper we systematically
restrict the set of allowed propositional connectives. We give a complete
complexity classification for all sets of Boolean functions in the meaning of
Post's lattice for all three common decision problems for propositional default
logic. We show that the complexity is a hexachotomy (SigmaP2-, DeltaP2-, NP-,
P-, NL-complete, trivial) for the extension existence problem, while for the
credulous and skeptical reasoning problem we obtain similar classifications
without trivial cases.Comment: Corrected versio
Multiple Pathways to Success: An Examination of Integrative Motivational Profiles Among Upper Elementary and College Students
Two studies were conducted with distinct samples to investigate how motivational beliefs cohere and function together (i.e., motivational profiles) and predict academic adjustment. Integrating across motivational theories, participants (NStudy 1 = 160 upper elementary students; NStudy 2 = 325 college students) reported on multiple types of motivation (achievement goals, task value, perceived competence) for schooling more generally (Study 1) and in science (Study 2). Three profiles characterized by Moderate-High All, Intrinsic and Confident, and Average All motivation were identified in both studies. Profiles characterized by Very High All motivation (Study 1) and Moderate Intrinsic and Confident (Study 2) were also present. Across studies, the Moderate-High All and Intrinsic and Confident profiles were associated with the highest academic engagement and achievement. Findings highlight the benefit of integrating across motivational theories when creating motivational profiles, provide initial evidence regarding similarities and differences in integrative motivational profiles across distinct samples, and identify which motivational combinations are associated with beneficial academic outcomes in two educational contexts
Nitrous oxide may not increase the risk of cancer recurrence after colorectal surgery: a follow-up of a randomized controlled trial
<p>Abstract</p> <p>Background</p> <p>Even the best cancer surgery is usually associated with minimal residual disease. Whether these remaining malignant cells develop into clinical recurrence is at least partially determined by adequacy of host defense, especially natural killer cell function. Anesthetics impair immune defenses to varying degrees, but nitrous oxide appears to be especially problematic. We therefore tested the hypothesis that colorectal-cancer recurrence risk is augmented by nitrous oxide administration during colorectal surgery.</p> <p>Methods</p> <p>We conducted a 4- to 8-year follow-up of 204 patients with colorectal cancer who were randomly assigned to 65% nitrous oxide (n = 97) or nitrogen (n = 107), balanced with isoflurane and remifentanil. The primary outcome was the time to cancer recurrence. Our primary analysis was a multivariable Cox-proportional-hazards regression model that included relevant baseline variables. In addition to treatment group, the model considered patient age, tumor grade, dissemination, adjacent organ invasion, vessel invasion, and the number of nodes involved. The study had 80% power to detect a 56% or greater reduction in recurrence rates (i.e., hazard ratio of 0.44 or less) at the 0.05 significance level.</p> <p>Results</p> <p>After adjusting for significant baseline covariables, risk of recurrence did not differ significantly for nitrous oxide and nitrogen, with a hazard ratio estimate (95% CI) of 1.10 (0.66, 1.83), <it>P </it>= 0.72. No two-way interactions with the treatment were statistically significant.</p> <p>Conclusion</p> <p>Colorectal-cancer recurrence risks were not greatly different in patients who were randomly assigned to 65% nitrous oxide or nitrogen during surgery. Our results may not support avoiding nitrous oxide use to prevent recurrence of colorectal cancer.</p> <p>Implications Statement</p> <p>The risk of colorectal cancer recurrence was similar in patients who were randomly assigned to 65% nitrous oxide or nitrogen during colorectal surgery.</p> <p>Trial Registration</p> <p>Current Controlled Clinical Trials NCT00781352 <url>http://www.clinicaltrials.gov</url></p
Electron-Electron Interaction in Disordered Mesoscopic Systems: Weak Localization and Mesoscopic Fluctuations of Polarizability and Capacitance
The weak localization correction and the mesoscopic fluctuations of the
polarizability and the capacitance of a small disordered sample are studied
systematically in 2D and 3D geometries. While the grand canonical ensemble
calculation gives the positive magnetopolarizability, in the canonical ensemble
(appropriate for isolated samples) the sign of the effect is reversed. The
magnitude of mesoscopic fluctuations for a single sample exceeds considerably
the value of the weak localization correction.Comment: 13 pages Latex, 3 .eps figures included. To appear in Phys. Rev. B.
Minor corrections, in particular in formulae; new references adde
The DLV System for Knowledge Representation and Reasoning
This paper presents the DLV system, which is widely considered the
state-of-the-art implementation of disjunctive logic programming, and addresses
several aspects. As for problem solving, we provide a formal definition of its
kernel language, function-free disjunctive logic programs (also known as
disjunctive datalog), extended by weak constraints, which are a powerful tool
to express optimization problems. We then illustrate the usage of DLV as a tool
for knowledge representation and reasoning, describing a new declarative
programming methodology which allows one to encode complex problems (up to
-complete problems) in a declarative fashion. On the foundational
side, we provide a detailed analysis of the computational complexity of the
language of DLV, and by deriving new complexity results we chart a complete
picture of the complexity of this language and important fragments thereof.
Furthermore, we illustrate the general architecture of the DLV system which
has been influenced by these results. As for applications, we overview
application front-ends which have been developed on top of DLV to solve
specific knowledge representation tasks, and we briefly describe the main
international projects investigating the potential of the system for industrial
exploitation. Finally, we report about thorough experimentation and
benchmarking, which has been carried out to assess the efficiency of the
system. The experimental results confirm the solidity of DLV and highlight its
potential for emerging application areas like knowledge management and
information integration.Comment: 56 pages, 9 figures, 6 table
Do Stress Responses Promote Leukemia Progression? An Animal Study Suggesting a Role for Epinephrine and Prostaglandin-E2 through Reduced NK Activity
In leukemia patients, stress and anxiety were suggested to predict poorer prognosis. Oncological patients experience ample physiological and psychological stress, potentially leading to increased secretion of stress factors, including epinephrine, corticosteroids, and prostaglandins. Here we tested whether environmental stress and these stress factors impact survival of leukemia-challenged rats, and studied mediating mechanisms. F344 rats were administered with a miniscule dose of 60 CRNK-16 leukemia cells, and were subjected to intermittent forced swim stress or to administration of physiologically relevant doses of epinephrine, prostaglandin-E2 or corticosterone. Stress and each stress factor, and/or their combinations, doubled mortality rates when acutely applied simultaneously with, or two or six days after tumor challenge. Acute administration of the β-adrenergic blocker nadolol diminished the effects of environmental stress, without affecting baseline survival rates. Prolonged β-adrenergic blockade or COX inhibition (using etodolac) also increased baseline survival rates, possibly by blocking tumor-related or normal levels of catecholamines and prostaglandins. Searching for mediating mechanisms, we found that each of the stress factors transiently suppressed NK activity against CRNK-16 and YAC-1 lines on a per NK basis. In contrast, the direct effects of stress factors on CRNK-16 proliferation, vitality, and VEGF secretion could not explain or even contradicted the in vivo survival findings. Overall, it seems that environmental stress, epinephrine, and prostaglandins promote leukemia progression in rats, potentially through suppressing cell mediated immunity. Thus, patients with hematological malignancies, which often exhibit diminished NK activity, may benefit from extended β-blockade and COX inhibition
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