382 research outputs found
Analysis of the Benefits of Green Streets
Green streets offer many potential benefits that include improving water quality, absorbing carbon (sequestration), and reducing urban heat island effects. This report summarizes: (1) the research teamâs analysis of 14 tools calculating green streets benefits; and (2) the results of applying the most promising calculators to a select group of green streets case studies. The researchers are affiliated with the Mineta Transportation Institute, which serves the California Department of Transportation (âCaltransâ). The report presents the results of the case study analyses, with an emphasis on carbon sequestration benefits and improvements to pedestrian levels of service (PLOS).
Trees absorb carbon dioxide and other pollutants from the air, reducing the costs of future climate change mitigations and medical care. Key findings obtained using i-Tree Design suggest that the monetary value (CO2 and air quality) of planting street trees is small but significant, with total estimated benefits from street trees on seven case study sites ranging from a low of 9,420 over a 20-year period. On a per tree basis, the lowest benefits come from site 3A (Cherry Avenue in San Jose) with 175 per tree.
While the Landis PLOS method accounts for the benefits of short street tree spacings (i.e., a high number of trees) and of having a continuous biostrip or planter strip serving as a pedestrian buffer, the method does not appear to be sensitive to tree spacings, though it is very sensitive to buffers. Therefore, the importance of having a biostrip or planter strip buffer between the sidewalk and street traffic is also reflected in the PLOS findings in this study.
While the measurable benefits of a handful of street trees may seem small, this study suggests that using i-Tree Design to add together the trees planted by local and state agencies has the potential to provide a compelling picture of the carbon sequestration benefits across California. Similarly, the use of Highway Capacity Manual (HCM)-based pedestrian level of service methods by transportation professionals can bring significant gains in the appreciation of green streetsâ benefits
A Mass Bound for Spherically Symmetric Black Hole Spacetimes
Requiring that the matter fields are subject to the dominant energy
condition, we establish the lower bound for the
total mass of a static, spherically symmetric black hole spacetime. ( and denote the area and the surface gravity of the horizon,
respectively.) Together with the fact that the Komar integral provides a simple
relation between and the strong energy condition,
this enables us to prove that the Schwarzschild metric represents the only
static, spherically symmetric black hole solution of a selfgravitating matter
model satisfying the dominant, but violating the strong energy condition for
the timelike Killing field at every point, that is, .
Applying this result to scalar fields, we recover the fact that the only black
hole configuration of the spherically symmetric Einstein-Higgs model with
arbitrary non-negative potential is the Schwarzschild spacetime with constant
Higgs field. In the presence of electromagnetic fields, we also derive a
stronger bound for the total mass, involving the electromagnetic potentials and
charges. Again, this estimate provides a simple tool to prove a ``no-hair''
theorem for matter fields violating the strong energy condition.Comment: 16 pages, LATEX, no figure
NR4A Gene Expression Is Dynamically Regulated in the Ventral Tegmental Area Dopamine Neurons and Is Related to Expression of Dopamine Neurotransmission Genes
The NR4A transcription factors NR4A1, NR4A2, and NR4A3 (also known as Nur77, Nurr1, and Nor1, respectively) share similar DNA-binding properties and have been implicated in regulation of dopamine neurotransmission genes. Our current hypothesis is that NR4A gene expression is regulated by dopamine neuron activity and that induction of NR4A genes will increase expression of dopamine neurotransmission genes. Eticlopride and Îł-butyrolactone (GBL) were used in wild-type (+/+) and Nurr1-null heterozygous (+/â) mice to determine the mechanism(s) regulating Nur77 and Nurr1 expression. Laser capture microdissection and real-time PCR was used to measure Nurr1 and Nur77 mRNA levels in the ventral tegmental area (VTA). Nur77 expression was significantly elevated 1Â h after both GBL (twofold) and eticlopride (fourfold). In contrast, GBL significantly decreased Nurr1 expression in both genotypes, while eticlopride significantly increased Nurr1 expression only in the +/+ mice. In a separate group of mice, haloperidol injection significantly elevated Nur77 and Nor1, but not Nurr1 mRNA in the VTA within 1Â h and significantly increased tyrosine hydroxylase (TH) and dopamine transporter (DAT) mRNA expression by 4Â h. These data demonstrate that the NR4A genes are dynamically regulated in dopamine neurons with maintenance of Nurr1 expression requiring dopamine neuron activity while both attenuation of dopamine autoreceptors activation and dopamine neuronal activity combining to induce Nur77 expression. Additionally, these data suggest that induction of NR4A genes could regulate TH and DAT expression and ultimately regulate dopamine neurotransmission
Triangulations and Severi varieties
We consider the problem of constructing triangulations of projective planes
over Hurwitz algebras with minimal numbers of vertices. We observe that the
numbers of faces of each dimension must be equal to the dimensions of certain
representations of the automorphism groups of the corresponding Severi
varieties. We construct a complex involving these representations, which should
be considered as a geometric version of the (putative) triangulations
THE UNIQUENESS THEOREM FOR ROTATING BLACK HOLE SOLUTIONS OF SELF-GRAVITATING HARMONIC MAPPINGS
We consider rotating black hole configurations of self-gravitating maps from
spacetime into arbitrary Riemannian manifolds. We first establish the
integrability conditions for the Killing fields generating the stationary and
the axisymmetric isometry (circularity theorem). Restricting ourselves to
mappings with harmonic action, we subsequently prove that the only stationary
and axisymmetric, asymptotically flat black hole solution with regular event
horizon is the Kerr metric. Together with the uniqueness result for
non-rotating configurations and the strong rigidity theorem, this establishes
the uniqueness of the Kerr family amongst all stationary black hole solutions
of self-gravitating harmonic mappings.Comment: 18 pages, latex, no figure
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Investigating the impact of poverty on colonization and infection with drug-resistant organisms in humans: a systematic review
Background
Poverty increases the risk of contracting infectious diseases and therefore exposure to antibiotics. Yet there is lacking evidence on the relationship between income and non-income dimensions of poverty and antimicrobial resistance. Investigating such relationship would strengthen antimicrobial stewardship interventions.
Methods
A systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed, Ovid, MEDLINE, EMBASE, Scopus, CINAHL, PsychINFO, EBSCO, HMIC, and Web of Science databases were searched in October 2016. Prospective and retrospective studies reporting on income or non-income dimensions of poverty and their influence on colonisation or infection with antimicrobial-resistant organisms were retrieved. Study quality was assessed with the Integrated quality criteria for review of multiple study designs (ICROMS) tool.
Results
Nineteen articles were reviewed. Crowding and homelessness were associated with antimicrobial resistance in community and hospital patients. In high-income countries, low income was associated with Streptococcus pneumoniae and Acinetobacter baumannii resistance and a seven-fold higher infection rate. In low-income countries the findings on this relation were contradictory. Lack of education was linked to resistant S. pneumoniae and Escherichia coli. Two papers explored the relation between water and sanitation and antimicrobial resistance in low-income settings.
Conclusions
Despite methodological limitations, the results suggest that addressing social determinants of poverty worldwide remains a crucial yet neglected step towards preventing antimicrobial resistance
Calibrated Sub-Bundles in Non-Compact Manifolds of Special Holonomy
This paper is a continuation of math.DG/0408005. We first construct special
Lagrangian submanifolds of the Ricci-flat Stenzel metric (of holonomy SU(n)) on
the cotangent bundle of S^n by looking at the conormal bundle of appropriate
submanifolds of S^n. We find that the condition for the conormal bundle to be
special Lagrangian is the same as that discovered by Harvey-Lawson for
submanifolds in R^n in their pioneering paper. We also construct calibrated
submanifolds in complete metrics with special holonomy G_2 and Spin(7)
discovered by Bryant and Salamon on the total spaces of appropriate bundles
over self-dual Einstein four manifolds. The submanifolds are constructed as
certain subbundles over immersed surfaces. We show that this construction
requires the surface to be minimal in the associative and Cayley cases, and to
be (properly oriented) real isotropic in the coassociative case. We also make
some remarks about using these constructions as a possible local model for the
intersection of compact calibrated submanifolds in a compact manifold with
special holonomy.Comment: 20 pages; for Revised Version: Minor cosmetic changes, some
paragraphs rewritten for improved clarit
Controllability on infinite-dimensional manifolds
Following the unified approach of A. Kriegl and P.W. Michor (1997) for a
treatment of global analysis on a class of locally convex spaces known as
convenient, we give a generalization of Rashevsky-Chow's theorem for control
systems in regular connected manifolds modelled on convenient
(infinite-dimensional) locally convex spaces which are not necessarily
normable.Comment: 19 pages, 1 figur
Effect of Computer-Assisted Cognitive Behavior Therapy vs Usual Care on Depression Among Adults in Primary Care: A Randomized Clinical Trial
Importance Depression is a common disorder that may go untreated or receive suboptimal care in primary care settings. Computer-assisted cognitive behavior therapy (CCBT) has been proposed as a method for improving access to effective psychotherapy, reducing cost, and increasing the convenience and efficiency of treatment for depression.
Objectives To evaluate whether clinician-supported CCBT is more effective than treatment as usual (TAU) in primary care patients with depression and to examine the feasibility and implementation of CCBT in a primary care population with substantial numbers of patients with low income, limited internet access, and low levels of educational attainment.
Design, Setting, and Participants This randomized clinical trial included adult primary care patients from clinical practices at the University of Louisville who scored 10 or greater on the Patient Health Questionnaireâ9 (PHQ-9) and were randomly assigned to CCBT or TAU for 12 weeks of active treatment. Follow-up assessments were conducted 3 and 6 months after treatment completion. Enrollment occurred from June 24, 2016, to May 13, 2019. The last follow-up assessment was conducted on January 30, 2020.
Interventions CCBT included use of the 9-lesson computer program Good Days Ahead, along with as many as 12 weekly telephonic support sessions of approximately 20 minutes with a masterâs level therapist, in addition to TAU, which consisted of the standard clinical management procedures at the primary care sites. TAU was uncontrolled, but use of antidepressants and psychotherapy other than CCBT was recorded.
Main Outcomes and Measures The primary outcome measure (PHQ-9) and secondary outcome measures (Automatic Thoughts Questionnaire for negative cognitions, Generalized Anxiety Disorderâ7, and the Satisfaction with Life Scale for quality of life) were administered at baseline, 12 weeks, and 3 and 6 months after treatment completion. Satisfaction with treatment was assessed with the Client Satisfaction Questionnaireâ8.
Results The sample of 175 patients was predominately female (147 of 174 [84.5%]) and had a high proportion of individuals who identified as racial and ethnic minority groups (African American, 44 of 162 patients who reported [27.2%]; American Indian or Alaska Native, 2 [1.2%]; Hispanic, 4 [2.5%]; multiracial, 14 [8.6%]). An annual income of less than $30âŻ000 was reported by 88 of 143 patients (61.5%). Overall, 95 patients (54.3%) were randomly assigned to CCBT and 80 (45.7%) to TAU. Dropout rates were 22.1% for CCBT (21 patients) and 30.0% for TAU (24 patients). An intent-to-treat analysis found that CCBT led to significantly greater improvement in PHQ-9 scores than TAU at posttreatment (mean difference, â2.5; 95% CI, â4.5 to â0.8; Pâ=â.005) and 3 month (mean difference, â2.3; 95% CI, â4.5 to â0.8; Pâ=â.006) and 6 month (mean difference, â3.2; 95% CI, â4.5 to â0.8; Pâ=â.007) follow-up points. Posttreatment response and remission rates were also significantly higher for CCBT (response, 58.4% [95% CI, 46.4-70.4%]; remission, 27.3% [95% CI, 16.4%-38.2%]) than TAU (response, 33.1% [95% CI, 20.7%-45.5%]; remission, 12.0% [95% CI, 3.3%- 20.7%]).
Conclusions and Relevance In this randomized clinical trial, CCBT was found to have significantly greater effects on depressive symptoms than TAU in primary care patients with depression. Because the study population included people with lower income and lack of internet access who typically have been underrepresented or not included in earlier investigations of CCBT, results suggest that this form of treatment can be acceptable and useful in diverse primary care settings. Additional studies with larger samples are needed to address implementation procedures that could enhance the effectiveness of CCBT and to examine potential factors associated with treatment outcome
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