Active inference and oculomotor pursuit: the dynamic causal modelling of eye movements.

This paper introduces a new paradigm that allows one to quantify the Bayesian beliefs evidenced by subjects during oculomotor pursuit. Subjects' eye tracking responses to a partially occluded sinusoidal target were recorded non-invasively and averaged. These response averages were then analysed using dynamic causal modelling (DCM). In DCM, observed responses are modelled using biologically plausible generative or forward models - usually biophysical models of neuronal activity

First-Generation Latinas’ Perspectives of College Involvement: A Phenomenological Study

The purpose of this study was to understand how first-generation Latinas define college involvement and how they feel this involvement contributed to their successful graduation from a community college. Because more Latinas are successfully completing college than their male counterparts (Latinos), this study sought to better understand the validating and student involvement factors that allow Latinas, who are also first-generation college students, to graduate from college. Community colleges are the primary entry into higher education for this student group; therefore, the study sought to explore college involvement at this type of institution. This study utilized a phenomenological approach to describe the experiences of nine first-generation Latina students who earned an associate degree from a community college within the past 3 years. Data was obtained via qualitative exploration using in-depth interviews that were coded and analyzed to develop themes. The researcher uncovered eight areas that the participants linked to their level of involvement in college activities. These areas were receiving information, confidence, growth, college support, family support, peer support, continued support, and early involvement. This study makes recommendations on how institutions can make improvements in practice and create an environment where first-generation Latina students can be involved and reach academic success. The recommendations include initiating early contact with students, creating academic support programs, and utilizing peer support

Analyses of Aliphatic Aldehydes and Ketones in Carbonaceous Chondrites

Aliphatic aldehydes and ketones are essential building blocks for the synthesis of more complex organic compounds. In spite of their potentially key role as precursors of astrobiologically-important molecules, such as amino acids and carboxylic acids, this family of compounds has scarcely been evaluated in carbonaceous chondrites. The paucity of such analyses likely derives from the low concentration of aldehydes and ketones in the meteorites, and from the currently used chromatographic methodologies that have not been optimized for meteorite analysis. In this work, we report the development of a novel analytical method to quantify the molecular distribution and compound-specific isotopic analysis of 29 aliphatic aldehydes and ketones. Using this method, we have investigated the molecular distribution and 13C-isotopic composition of aldehydes and ketones in ten carbonaceous chondrites from the CI, CM, CR and CV groups. The total concentration of carbonyl compounds ranged from 130 to 1000 nmolg-1 of meteorite, with formaldehyde, acetaldehyde, and acetone being the most abundant species in all investigated samples. The 13C-isotopic values ranged from 67 to +64 and we did not observe clear relationships between 13C-content and molecular weight. Accurately measuring the relative abundances, determining the molecular distribution, and isotopic composition of chondritic organic compounds is central in assessing both their formation chemistry and synthetic relationships

Compound-specific Carbon Isotope Compositions of Aldehydes and Ketones in the Murchison Meteorite

Compoundspecific carbon isotope analysis (13C) of meteoritic organic compounds can be used to elucidate the abiotic chemical reactions involved in their synthesis. The soluble organic content of the Murchison carbonaceous chondrite has been extensively investigated over the years, with a focus on the origins of amino acids and the potential role of Streckercyanohydrin synthesis in the early solar system. Previous 13C investigations have targeted amino acid and hydroxy acid Strecker products and reactant HCN; however, 13C values for meteoritic aldehydes and ketones (Strecker precursors) have not yet been reported. As such, the distribution of aldehydes and ketones in the cosmos and their role in prebiotic reactions have not been fully investigated. Here, we have applied an optimized O(2,3,4,5,6pentafluorobenzyl)hydroxylamine (PFBHA) derivatization procedure to the extraction, identification, and 13C analysis of carbonyl compounds in the Murchison meteorite. A suite of aldehydes and ketones, dominated by acetaldehyde, propionaldehyde, and acetone, were detected in the sample. 13C values, ranging from 10.0 to +66.4, were more 13Cdepleted than would be expected for aldehydes and ketones derived from the interstellar medium, based on interstellar 12C/13C ratios. These relatively 13Cdepleted values suggest that chemical processes taking place in asteroid parent bodies (e.g., oxidation of the IOM) may provide a secondary source of aldehydes and ketones in the solar system. Comparisons between 13C compositions of meteoritic aldehydes and ketones and other organic compound classes were used to evaluate potential structural relationships and associated reactions, including Strecker synthesis and alterationdriven chemical pathways

Molecular Distribution, 13C-Isotope, and Enantiomeric Compositions of Carbonaceous Chondrite Monocarboxylic Acids

The watersoluble organic compounds in carbonaceous chondrite meteorites constitute a record of the synthetic reactions occurring at the birth of the solar system and those taking place during parent body alteration and may have been important for the later origins and development of life on Earth. In this present work, we have developed a novel methodology for the simultaneous analysis of the molecular distribution, compoundspecific 13C, and enantiomeric compositions of aliphatic monocarboxylic acids (MCA) extracted from the hotwater extracts of 16 carbonaceous chondrites from CM, CR, CO, CV, and CK groups. We observed high concentrations of meteoritic MCAs, with total carbon weight percentages which in some cases approached those of carbonates and insoluble organic matter. Moreover, we found that the concentration of MCAs in CR chondrites is higher than in the other meteorite groups, with acetic acid exhibiting the highest concentration in all samples. The abundance of MCAs decreased with increasing molecular weight and with increasing aqueous and/or thermal alteration experienced by the meteorite sample. The 13C isotopic values of MCAs ranged from 52 to +27, and aside from an inverse relationship between 13C value and carbon straightchain length for C3C6 MCAs in Murchison, the 13Cisotopic values did not correlate with the number of carbon atoms per molecule. We also observed racemic compositions of 2methylbutanoic acid in CM and CR chondrites. We used this novel analytical protocol and collective data to shed new light on the prebiotic origins of chondritic MCAs

Kierkegaard y el salto de fe. Un acto de individualidad

The purpose of this essay is to analyze succinctly the concept of faith through the very penetrating gaze of the Danish philosopher Sören Kierkegaard. Faith is analyzed by Kierkegaard from absurdity, resignation and the paradox of faith. In the same way, his concept of faith is carved with a chisel that would complete all his philosophy, that is, to touch human reality away from any abstract thought, trying at all times that his examination be seen on a personal dimension in his rigorously individual coretEl presente ensayo tiene por objeto analizar de forma sucinta el concepto de fe a través la muy penetrante mirada del filósofo danés Sören Kierkegaard. La Fe es analizada por Kierkegaard a partir del absurdo, la resignación y la paradoja de la fe. De igual manera, su concepto de fe es tallado con un cincel que completaría toda su filosofía, esto es, tocar la realidad humana lejos de cualquier pensamiento abstracto, procurando en todo momento que su examen verse sobre una dimensión personal en su núcleo rigurosamente individual

Diseño de mezclas de hormigón reciclado mediante el método Volumen de Mortero Equivalente (EMV): Validación bajo el contexto español y su adaptación al método de diseño de Bolomey

A new method for proportioning recycled aggregates concrete (RAC) is used to check its feasibility under the Spanish context. First, an extensive experimental campaign has been done, with the purpose of check and analyze the applicability of the EMV method with two Spanish recycled concrete aggregates (RCA). The aim of the second part of the investigation, was to elaborate an adaptation of the EMV method to Bolomey methodology (1), using a 20% weight replacement of coarse natural aggregates (NA) for RCA, and so, with this, comply with the Spanish Instruction for Structural Concrete (EHE 2008). Slump, air content, fresh and hardened densities, compressive strength and modulus of elasticity were determined and analyzed, in order to check the concrete properties. Finally, it was observed that, the EMV method is viable, and its adaptation, results in concrete mixes with similar or better properties than the natural aggregate concrete and RAC conventionally prepared.El nuevo método para el diseño de hormigón con árido reciclado (HAR) es usado para comprobar su posibilidad de uso bajo el contexto español. Primeramente, se realiza una extensa campaña experimental, para analizar las posibilidades de su aplicación, usando dos áridos reciclados de hormigón (ARH) españoles. En la segunda etapa se elabora una adaptación del método a la metodología propuesta por Bolomey (1), con 20% de reemplazo en peso de árido grueso natural (AN) por ARH, para así cumplir con las recomendaciones estipuladas en la Instrucción de Hormigón Estructural (EHE 2008). Para determinar y analizar las propiedades del hormigón, se llevaron a cabo ensayos de asentamiento, contenido de aire, densidades, módulo elástico y resistencias a compresión. Finalmente, se concluye que el uso del nuevo método es viable, y que su adaptación produce hormigones con similares o mejores características que los elaborados para hormigón con árido convencional (HAC) y HAR convencionales

Pathways to Meteoritic Glycine and Methylamine

Glycine and methylamine are meteoritic water-soluble organic compounds that provide insights into the processes that occurred before, during, and after the formation of the Solar System. Both glycine and methylamine and many of their potential synthetic precursors have been studied in astrophysical environments via observations, laboratory experiments, and modeling. Despite these studies, the synthetic mechanisms for their formation leading to their occurrence in meteorites remain poorly understood. Typical 13C-isotopic values (13C) of meteoritic glycine and methylamine are 13C-enriched relative to their terrestrial counterparts; thus, analyses of their stable carbon isotopic compositions (13C/12C) may be used not only to assess terrestrial contamination in meteorites but also to provide information about their synthetic routes inside the parent body. Here, we examine potential synthetic routes of glycine and methylamine from a common set of precursors present in carbonaceous chondrite meteorites, using data from laboratory analyses of the well-studied CM2 Murchison meteorite. Several synthetic mechanisms for the origins of glycine and methylamine found in carbonaceous chondrites may be possible, and the prevalence of these mechanisms will largely depend on (a) the molecular abundance of the precursor molecules and (b) the levels of processing (aqueous and thermal) that occurred inside the parent body. In this work, we also aim to contextualize the current knowledge about gas-phase reactions and irradiated ice grain chemistry for the synthesis of these species through parent body processes. Our evaluation of various mechanisms for the origins of meteoritic glycine and methylamine from simple species shows what work is still needed to evaluate both the abundances and isotopic compositions of simpler precursor molecules from carbonaceous chondrites as well as the effects of parent body processes on those abundances and isotopic compositions. The analyses presented here combined with the indicated measurements will aid a better interpretation of quantitative analysis of reaction rates, molecular stability, and distribution of organic products from laboratory simulations of interstellar ices, astronomical observations, and theoretical modeling

Subjective estimates of uncertainty during gambling and impulsivity after subthalamic deep brain stimulation for Parkinson\u2019s disease

Subthalamic deep brain stimulation (DBS) for Parkinson\u2019s disease (PD) may modulate chronometric and instrumental aspects of choice behaviour, including motor inhibition, decisional slowing, and value sensitivity. However, it is not well known whether subthalamic DBS affects more complex aspects of decision-making, such as the influence of subjective estimates of uncertainty on choices. In this study, 38 participants with PD played a virtual casino prior to subthalamic DBS (whilst \u2018on\u2019 medication) and again, 3-months postoperatively (whilst \u2018on\u2019 stimulation). At the group level, there was a small but statistically significant decrease in impulsivity postoperatively, as quantified by the Barratt Impulsiveness Scale (BIS). The gambling behaviour of participants (bet increases, slot machine switches and double or nothing gambles) was associated with this self-reported measure of impulsivity. However, there was a large variance in outcome amongst participants, and we were interested in whether individual differences in subjective estimates of uncertainty (specifically, volatility) were related to differences in pre- and postoperative impulsivity. To examine these individual differences, we fit a computational model (the Hierarchical Gaussian Filter, HGF), to choices made during slot machine game play as well as a simpler reinforcement learning model based on the Rescorla-Wagner formalism. The HGF was superior in accounting for the behaviour of our participants, suggesting that participants incorporated beliefs about environmental uncertainty when updating their beliefs about gambling outcome and translating these beliefs into action. A specific aspect of subjective uncertainty, the participant\u2019s estimate of the tendency of the slot machine\u2019s winning probability to change (volatility), increased subsequent to DBS. Additionally, the decision temperature of the response model decreased post-operatively, implying greater stochasticity in the belief-to-choice mapping of participants. Model parameter estimates were significantly associated with impulsivity; specifically, increased uncertainty was related to increased postoperative impulsivity. Moreover, changes in these parameter estimates were significantly associated with the maximum post-operative change in impulsivity over a six month follow up period. Our findings suggest that impulsivity in PD patients may be influenced by subjective estimates of uncertainty (environmental volatility) and implicate a role for the subthalamic nucleus in the modulation of outcome certainty. Furthermore, our work outlines a possible approach to characterising those persons who become more impulsive after subthalamic DBS, an intervention in which non-motor outcomes can be highly variable