17 research outputs found
The stabilizing role of higher-order strain gradients in non-linear thermoviscoplasticity
On stress controlled thermoviscoplastic shearing and higher order strain gradients
We give a brief discussion on the stability and non-uniformity of shear in a slab of finite width and infinite extent made from a non-hardening, non-conducting, anisothermal viscoplastic material with stress controlled boundary conditions. The new ingredient in our analysis is the inclusion of higher-order strain gradients in the expression for the flow stress. It is shown that this inclusion allows for the development of non-uniformities for a certain condition between the thermomechanical parameters for which the classical model (absence of strain gradients) imposes a uniformly evolving stable solution
What do we know about capital structure? Revisiting the impact of debt ratios on some firm-specific factors
Can thromboprophylaxis build a link for cancer patients undergoing surgical and/or chemotherapy treatment? The MeTHOS cohort study
Background: Patients with active cancer have a 4–sevenfold increased risk for venous thromboembolism (VTE) especially during systematic anticancer treatment. Simultaneously, surgery is an additional risk factor. Methods: The Metaxas’s Hospital THromboprophylaxis program in Oncological & Surgical Patients (MeTHOS) is a prospective, phase IV, observational, non-interventional cohort study, aiming to record the thromboprophylaxis practice patterns in high-risk active cancer patients undergoing surgical and/or chemotherapy treatment. Results: We are reporting results from 291 ambulatory patients (median age: 67 years, Q1–Q3: 59–73 years, 54.6% males) who received anti-neoplastic treatment and administered thromboprophylaxis. 59.8% had cardiovascular disease (mostly hypertension), 76.6% were reported as having at least one comorbidity, while 27.5% and 15.8% accumulated two and three comorbidities, respectively. 94.9% of the patients were receiving highly thrombogenic agents such as platinum-based agents, 5-FU, immunotherapy, antiangiogenics/anti-VEGF, or erythropoietin. 26.5% of the patients were initially surgically treated. In terms of anticoagulation, all patients were treated with tinzaparin (fixed dose, 10,000 Anti-Xa IU, OD). The median anticoagulation duration was 6.2 months. Six thrombotic events were observed (2.06%, 95% CI: 0.76–4.43%): 5 were DVT, and one PE. With respect to safety, 7 bleeding events occurred (2.6%, 95% CI: 1.0–5.3%); 6 of them were minor. Conclusions: Thromboprophylaxis with LMWH in patients with active cancer and high thrombotic burden was safe and effective. Intermediate dose of tinzaparin seems to be an appropriate agent for cancer-associated thromboprophylaxis management. Clinical trial registration: ClinicalTrials.gov: NCT04248348. © 2022, The Author(s)