Neither slugs nor snails: a molecular reappraisal of the gastropod family Velutinidae

The systematics of the marine mollusc family Velutinidae has long been neglected by taxonomists, mainly because their often internal and fragile shells offer no morphological characters. Velutinids are usually undersampled owing to their cryptic mantle coloration on the solitary, social or colonial ascidians on which they feed and lay eggs. In this study, we address the worldwide diversity and phylogeny of Velutinidae based on the largest molecular dataset (313 specimens) to date, accounting for > 50% of the currently accepted genera, coupled with morphological and ecological data. Velutinids emerge as a diverse group, encompassing four independent subfamily-level lineages, two of which are newly described herein: Marseniopsinae subfam. nov. and Hainotinae subfam. nov. High diversity was found at genus and species levels, with two newly described genera (Variolipallium gen. nov. and Pacifica gen. nov.) and ≥ 86 species in the assayed dataset, 58 of which are new to science (67%). Velutinidae show a remarkable morphological plasticity in shell morphology, mantle extension and chromatic patterns. This variability is likely to be the result of different selective forces, including habitat, depth and trophic interactions

Re-evaluation of the LHC potential for the measurement of Mw

We present a study of the LHC sensitivity to the W boson mass based on simulation studies. We find that both experimental and phenomenological sources of systematic uncertainties can be strongly constrained with Z measurements: the lineshape is robustly predicted, and its analysis provides an accurate measurement of the detector resolution and absolute scale, while the differential cross-section analysis absorbs most of the strong interaction uncertainties. A sensitivity \delta Mw \sim 7 \MeV for each decay channel (W --> e nu, W --> mu nu), and for an integrated luminosity of 10 fb-1, appears as a reasonable goal

Standard Model Handles and Candles Working Group: Tools and Jets Summary Report

This report summarizes the activity on comparisons of existings tools for the standard model and on issues in jet physics by the SMHC working group during and subsequent to the Workshop "Physics at TeV Colliders", Les Houches, France, 11-29 June, 2007.Comment: 94 pages, LaTeX, many figures. Summary report of the tools and jets parts of the SMHC working group of the Les Houches 2007 workshop "Physics at TeV Colliders", Les Houches, France, 11-29 June, 200

Acute mucosal pathogenesis of feline immunodeficiency virus is independent of viral dose in vaginally infected cats

<p>Abstract</p> <p>Background</p> <p>The mucosal pathogenesis of HIV has been shown to be an important feature of infection and disease progression. HIV-1 infection causes depletion of intestinal lamina propria CD4+ T cells (LPL), therefore, intestinal CD4+ T cell preservation may be a useful correlate of protection in evaluating vaccine candidates. Vaccine studies employing the cat/FIV and macaque/SIV models frequently use high doses of parenterally administered challenge virus to ensure high plasma viremia in control animals. However, it is unclear if loss of mucosal T cells would occur regardless of initial viral inoculum dose. The objective of this study was to determine the acute effect of viral dose on mucosal leukocytes and associated innate and adaptive immune responses.</p> <p>Results</p> <p>Cats were vaginally inoculated with a high, middle or low dose of cell-associated and cell-free FIV. PBMC, serum and plasma were assessed every two weeks with tissues assessed eight weeks following infection. We found that irrespective of mucosally administered viral dose, FIV infection was induced in all cats. However, viremia was present in only half of the cats, and viral dose was unrelated to the development of viremia. Importantly, regardless of viral dose, all cats experienced significant losses of intestinal CD4+ LPL and CD8+ intraepithelial lymphocytes (IEL). Innate immune responses by CD56+CD3- NK cells correlated with aviremia and apparent occult infection but did not protect mucosal T cells. CD4+ and CD8+ T cells in viremic cats were more likely to produce cytokines in response to Gag stimulation, whereas aviremic cats T cells tended to produce cytokines in response to Env stimulation. However, while cell-mediated immune responses in aviremic cats may have helped reduce viral replication, they could not be correlated to the levels of viremia. Robust production of anti-FIV antibodies was positively correlated with the magnitude of viremia.</p> <p>Conclusions</p> <p>Our results indicate that mucosal immune pathogenesis could be used as a rapid indicator of vaccine success or failure when combined with a physiologically relevant low dose mucosal challenge. We also show that innate immune responses may play an important role in controlling viral replication following acute mucosal infection, which has not been previously identified.</p

Les faunes de Bryozoaires du néogène de l'Ouest de la France et leurs rapports avec celles du néogène méditerranéen

National audienc

Catalogue des Bryozoaires types et figur\ue9s de la collection du Laboratoire de Pal\ue9ontologie du Mus\ue9um national d\u27Histoire naturelle. \ue2€” 11. Bryozoaires actuels du Maroc et de Mauritanie figur\ue9s par F. Canu et R. S. Bassler (1925-1928)

Volume: 18Start Page: 274End Page: 27

Catalogue des Bryozoaires types et figur\ue9s de la collection du laboratoire de Pal\ue9ontologie du Mus\ue9um National d\u27Histoire naturelle. \ue2€” I. Bryozoaires du patagonien figur\ue9s par F. Canu (1904-1908). \ue2€” La position stratigraphique du patagonien

Volume: 18Start Page: 204End Page: 21

R\ue9vision du genre Idmidronea (Canu et Bassler mss.) Canu 1919 (Bryozoa, Cyclostomata). II, Syst\ue9matique et conclusions

Volume: 20Start Page: 183End Page: 18

Catalogue des Bryozoaires types et figur\ue9s de la collection du Laboratoire de Pal\ue9ontologie du Mus\ue9um national d\u27Histoire naturelle. III. Bryozoaires cyclostomes de l\u27Eoc\ue8ne du Bassin de Paris figur\ue9s par F. Canu (1907-1910)

Volume: 18Start Page: 366End Page: 37