Achieving High Organization Performance through Servant Leadership

This empirical paper investigates whether a servant leader can develop a corporate culture that attracts or develops other servant leaders. Using the survey developed by Barbuto and Wheeler (2006), servant leader characteristics in managers were measured at three high-performing organizations. Results indicate that servant leaders can develop a culture of followers who are servant leaders themselves. This is one of the few studies to empirically test the model of servant leadership in an organizational environment. The success these servant leaders have achieved in a for-profit, demanding environment suggests this leadership style is viable for adoption by other firms

Parallel Mechanisms between Placental Amyloidosis/Preeclampsia and Neurodegenerative Diseases

This short review summarizes recent studies on placenta-preeclampsia in the mother and/or intrauterine growth restriction in the child. The ideas raised here are framed within a paradigm that favors the opening of new research lines in these themes and are focused on the outlining of early investigation and/or an adequate treatment for mothers who develop the pathology. Thus, this review focuses on those studies that categorize PE in the group of pathologies defined as "conformational diseases", as a consequence of the misfolding of proteins due to endoplasmic reticulum ER stress. In this particular case, the ER stress that develops in the syncytiotrophoblast because of the oxidative stress caused in the placenta by the hypoxia that occurs as a consequence of the failure in the remodeling of endometrial arteries. This leads to an increased syncytiotrophoblast apoptosis with detachment of misfolded proteins into the maternal circulation, which in turn would be primarily responsible for the signs of preeclampsia in the mother: proteinuria, edema, and hypertension. The review also analyzes the preeclampsia-prions-placenta relationship, since the normal cell-surface protein PrPc is normally present in the plasma membrane of syncytiotrophoblast, but appears to be increased in cases of preeclampsia. However, although neurodegenerative disorders resulting from conformational changes in the prion protein from its normal cellular form, PrPc, to the infectious scrapie isoform, PrPSc are well known, limited information is available on Pr Pc and PrPSc in the ST, hence review on these proteins gains more attention in normal and pathological placenta

Effects of Hypohydration on Work Performance and Tolerance to plus Gz Acceleration in Man

Hypohydration effects on work performance and tolerance to acceleration stress in ma

Differential role of RB in response to UV and IR damage

The retinoblastoma tumor suppressor (RB) is functionally inactivated in the majority of cancers and is a critical mediator of DNA damage checkpoints. Despite the critical importance of RB function in tumor suppression, the coordinate impact of RB loss on the response to environmental and therapeutic sources of damage has remained largely unexplored. Here, we utilized a conditional knockout system to ablate RB in adult fibroblasts. This model system enabled us to investigate the temporal role of RB loss on cell cycle checkpoints and DNA damage repair following ultraviolet (UV) and ionizing radiation (IR) damage. We demonstrate that RB loss compromises rapid cell cycle arrest following UV and IR exposure in adult primary cells. Detailed kinetic analysis of the checkpoint response revealed that disruption of the checkpoint is concomitant with RB target gene deregulation, and is not simply a manifestation of chronic RB loss. RB loss had a differential effect upon repair of the major DNA lesions induced by IR and UV. Whereas RB did not affect resolution of DNA double-strand breaks, RB-deficient cells exhibited accelerated repair of pyrimidine pyrimidone photoproducts (6-4 PP). In parallel, this repair was coupled with enhanced expression of specific factors and the behavior of proliferating cell nuclear antigen (PCNA) recruitment to replication and repair foci. Thus, RB loss and target gene deregulation hastens the repair of specific lesions distinct from its ubiquitous role in checkpoint abrogation

Nivel de satisfacción de las mujeres, en la atención del parto vaginal en la sala de puerperio fisiológico del Hospital Bertha Calderon Roque en el período de Abril–Agosto del 2014

La satisfacción de la mujer con la experiencia delnacimiento de su hijo es un indicador importante en la calidad de los servicios de atención obstétricos. El presente estudio se realizó bajo el marco conceptual de Mackey Childbirth Scale 1998). El cual considera cinco componentes de la satisfacción: ella misma, hijo, enfermera, médico y acompañante.El objetivo del presente trabajo fue determinar la satisfacción materna con la experiencia del nacimiento de su hijo considerando a la parturienta como un todo en su evaluación integral.Se realizó un estudio descriptivo de corte trasversal, con muestreo probabilístico en las salas de puerperio fisiológico mediato del Hospital Bertha Calderón, se contó con una población a estudio de 240 puérperas, como instrumento de medición se tomó en cuenta la escala antes descrita. Para su análisis estadístico se interpretó en porcentajes y frecuencias.Entre los hallazgos encontrados en este estudio se encontró el principal grupo etario que dio a luz fue las edades comprendidas entre 21 y 25 años, con escolaridad secundaria, unión estable de ocupación de ama de casa. Como tal se logró apreciar que las pacientes clasifican su experiencia de parto como positiva durante su proceso de parto vaginal