1,832 research outputs found

    Systematic Improvement of Parton Showers with Effective Theory

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    We carry out a systematic classification and computation of next-to-leading order kinematic power corrections to the fully differential cross section in the parton shower. To do this we devise a map between ingredients in a parton shower and operators in a traditional effective field theory framework using a chain of soft-collinear effective theories. Our approach overcomes several difficulties including avoiding double counting and distinguishing approximations that are coordinate choices from true power corrections. Branching corrections can be classified as hard-scattering, that occur near the top of the shower, and jet-structure, that can occur at any point inside it. Hard-scattering corrections include matrix elements with additional hard partons, as well as power suppressed contributions to the branching for the leading jet. Jet-structure corrections require simultaneous consideration of potential 1 -> 2 and 1 -> 3 branchings. The interference structure induced by collinear terms with subleading powers remains localized in the shower.Comment: 54 pages, 24 figures, plus a few appendices. v2: included a parameter "eta" to account for energy loss, title improved, journal versio

    A sensitive non-radioactive in situ hybridization method for the detection of chicken IgG γ-chain mRNA: a technique suitable for detecting of variety of mRNAs in tissue sections

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    We established a sensitive non-radioactive in situ hybridization (ISH) method for the detection of chicken IgG γ-chain mRNA in paraffin sections. RNA probes were transcribed in vitro from cloned chicken IgG CH1 nucleotide sequences with SP6/T7 RNA polymerases in the presence of DIG-UTP. These probes were used for hybridization and were immunodetected using anti-DIG antibodies conjugated to horseradish peroxidase. The immunoreactive products were visualized with DAB-H(2)O(2). IgG γ-chain mRNA-expressing cells were localized in both the spleen and oviductal tissues. This method demonstrated an excellent sensitivity since the ISH signal was clear and the background was negligible. We found that in the spleen IgG γ-chain mRNA-expressing cells were present mainly in the red pulp, whereas in the oviduct they appeared mainly in the mucosal stroma and not in the mucosal epithelium

    Banddehnungsmessung am Kniegelenk - Der Dehnungsmeßstreifen und seine Alternativen

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    Those techniques for measuring ligament tension at the knee joint that are most commonly cited and easiest to carry out are discussed, These include four techniques based on the use of strain gauges. Apart from the Omega transducer and the buckle transducer, there is also the tendon force transducer, and the application of strain gauges to the bony ligament insertion sites, Other indirect measuring methods considered are the mercury strain transducer and the Hall effect transducer. The parameter measured with all of these methods is fluctuating current or voltage, which is then correlated with ligament tension. Three direct measurements are also discussed: the separation distances of marked fibres of the ligaments, replacement of fibres by threads, and a load cell/bone plug construction. The measured value is equated with the effective change in ligament length

    Species-specific differences in peroxisome proliferation, catalase, and SOD2 upregulation as well as toxicity in human, mouse, and rat hepatoma cells induced by the explosive and environmental pollutant 2,4,6-trinitrotoluene

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    © 2016 Wiley Periodicals, Inc.2,4,6-Trinitrotoluene (TNT) has been widely used as an explosive substance and its toxicity is still of interest as it persisted in polluted areas. TNT is metabolized in hepatocytes which are prone to its toxicity. Since analysis of the human liver or hepatocytes is restricted due to ethical reasons, we investigated the effects of TNT on cell viability, reactive oxygen species (ROS) production, peroxisome proliferation, and antioxidative enzymes in human (HepG2), mouse (Hepa 1-6), and rat (H4IIEC3) hepatoma cell lines. Under control conditions, hepatoma cells of all three species were highly comparable exhibiting identical proliferation rates and distribution of their cell cycle phases. However, we found strong differences in TNT toxicity with the lowest IC50 values (highest cell death rate) for rat cells, whereas human and mouse cells were three to sevenfold less sensitive. Moreover, a strong decrease in cellular dehydrogenase activity (MTT assay) and increased ROS levels were noted. TNT caused peroxisome proliferation with rat hepatoma cells being most responsive followed by those from mouse and human. Under control conditions, rat cells contained fivefold higher peroxisomal catalase and mitochondrial SOD2 activities and a twofold higher capacity to reduce MTT than human and mouse cells. TNT treatment caused an increase in catalase and SOD2 mRNA and protein levels in human and mouse, but not in rat cells. Similarly, human and mouse cells upregulated SOD2 activity, whereas rat cells failed therein. We conclude that TNT induced oxidative stress, peroxisome proliferation and mitochondrial damage which are highest in rat cells rendering them most susceptible toward TNT. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 989–1006, 2017

    Capture and decay of electroweak WIMPonium

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    The spectrum of Weakly-Interacting-Massive-Particle (WIMP) dark matter generically possesses bound states when the WIMP mass becomes sufficiently large relative to the mass of the electroweak gauge bosons. The presence of these bound states enhances the annihilation rate via resonances in the Sommerfeld enhancement, but they can also be produced directly with the emission of a low-energy photon. In this work we compute the rate for SU(2) triplet dark matter (the wino) to bind into WIMPonium - which is possible via single-photon emission for wino masses above 5 TeV for relative velocity v < O(10-2) - and study the subsequent decays of these bound states. We present results with applications beyond the wino case, e.g. for dark matter inhabiting a nonabelian dark sector; these include analytic capture and transition rates for general dark sectors in the limit of vanishing force carrier mass, efficient numerical routines for calculating positive and negative-energy eigenstates of a Hamiltonian containing interactions with both massive and massless force carriers, and a study of the scaling of bound state formation in the short-range Hulth&apos;{e}n potential. In the specific case of the wino, we find that the rate for bound state formation is suppressed relative to direct annihilation, and so provides only a small correction to the overall annihilation rate. The soft photons radiated by the capture process and by bound state transitions could permit measurement of the dark matter's quantum numbers; for wino-like dark matter, such photons are rare, but might be observable by a future ground-based gamma-ray telescope combining large effective area and a low energy threshold

    Polarization of Bi2Te3 Thin Film in a Floating-Gate Capacitor Structure

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    Metal-Oxide-Semiconductor (MOS) capacitors with Bi2Te3 thin film sandwiched and embedded inside the oxide layer have been fabricated and studied. The capacitors exhibit ferroelectric-like hysteresis which is a result of the robust, reversible polarization of the Bi2Te3 thin film while the gate voltage sweeps. The temperature-dependent capacitance measurement indicates that the activation energy is about 0.33 eV for separating the electron and hole pairs in the bulk of Bi2Te3, and driving them to either the top or bottom surface of the thin film. Because of the fast polarization speed, potentially excellent endurance, and the complementary metal - oxide - semiconductor compatibility, the Bi2Te3 embedded MOS structures are very interesting for memory application. © 2014 AIP Publishing LLC

    Forces between clustered stereocilia minimize friction in the ear on a subnanometre scale

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    The detection of sound begins when energy derived from acoustic stimuli deflects the hair bundles atop hair cells. As hair bundles move, the viscous friction between stereocilia and the surrounding liquid poses a fundamental challenge to the ear's high sensitivity and sharp frequency selectivity. Part of the solution to this problem lies in the active process that uses energy for frequency-selective sound amplification. Here we demonstrate that a complementary part involves the fluid-structure interaction between the liquid within the hair bundle and the stereocilia. Using force measurement on a dynamically scaled model, finite-element analysis, analytical estimation of hydrodynamic forces, stochastic simulation and high-resolution interferometric measurement of hair bundles, we characterize the origin and magnitude of the forces between individual stereocilia during small hair-bundle deflections. We find that the close apposition of stereocilia effectively immobilizes the liquid between them, which reduces the drag and suppresses the relative squeezing but not the sliding mode of stereociliary motion. The obliquely oriented tip links couple the mechanotransduction channels to this least dissipative coherent mode, whereas the elastic horizontal top connectors stabilize the structure, further reducing the drag. As measured from the distortion products associated with channel gating at physiological stimulation amplitudes of tens of nanometres, the balance of forces in a hair bundle permits a relative mode of motion between adjacent stereocilia that encompasses only a fraction of a nanometre. A combination of high-resolution experiments and detailed numerical modelling of fluid-structure interactions reveals the physical principles behind the basic structural features of hair bundles and shows quantitatively how these organelles are adapted to the needs of sensitive mechanotransduction.Comment: 21 pages, including 3 figures. For supplementary information, please see the online version of the article at http://www.nature.com/natur
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