Post-ISCO Ringdown Amplitudes in Extreme Mass Ratio Inspiral

An extreme mass ratio inspiral consists of two parts: adiabatic inspiral and plunge. The plunge trajectory from the innermost stable circular orbit (ISCO) is special (somewhat independent of initial conditions). We write an expression for its solution in closed-form and for the emitted waveform. In particular we extract an expression for the associated black-hole ringdown amplitudes, and evaluate them numerically.Comment: 21 pages, 5 figures. v4: added section with numerical evaluation of the ringdown amplitude

Efficient ion-photon qubit SWAP gate in realistic ion cavity-QED systems without strong coupling

We present a scheme for deterministic ion-photon qubit exchange, namely a SWAP gate, based on realistic cavity-QED systems with 171Yb+, 40Ca+ and 138Ba+ ions. The gate can also serve as a single-photon quantum memory, in which an outgoing photon heralds the successful arrival of the incoming photonic qubit. Although strong coupling, namely having the single-photon Rabi frequency be the fastest rate in the system, is often assumed essential, this gate (similarly to the Duan-Kimble C-phase gate) requires only Purcell enhancement, i.e. high single-atom cooperativity. Accordingly, it does not require small mode volume cavities, which are challenging to incorporate with ions due to the difficulty of trapping them close to dielectric surfaces. Instead, larger cavities, potentially more compatible with the trap apparatus, are sufficient, as long as their numerical aperture is high enough to maintain small mode area at the ion's position. We define the optimal parameters for the gate's operation and simulate the expected fidelities and efficiencies, demonstrating that efficient photon-ion qubit exchange, a valuable building block for scalable quantum computation, is practically attainable with current experimental capabilities.Comment: 18 pages, 9 figure

An Indirect-Effects Model of Mediated Adjudication: The CSI Myth, the Tech Effect, and Metropolitan Jurors\u27 Expectations for Scientific Evidence

Part I of this article defines the CSI effect, a phrase has come to have many different meanings ascribed to it. It emphasizes the epistemological importance of first describing the effect of the CSI effect as observed in juror behavior documented in a new study conducted in Wayne County (Detroit), Michigan, and then looking at causative factors that may be related to an explanation of those observed effects. Part II describes the methodology of the Wayne County study, provides a descriptive analysis of Wayne County jurors, and compares the jurors demographically to the Washtenaw County jurors who were surveyed in 2006. Part III analyzes the Wayne County study results with respect to jurors\u27 expectations and demands for scientific evidence. The Wayne County study findings reinforce the earlier Washtenaw findings of heightened juror expectations and demands for scientific evidence in almost every respect. This most recent analysis reinforces conclusions from the earlier study that there is no such causative relationship between watching CSI and heightened juror expectations and demands. Part IV explores the nature of the tech effect as one causative factor for those heightened juror expectations and demands as an alternative to the CSI effect. The results of regression analyses of new data provide some support for the 2006 study\u27s suggestion of a tech effect --that the broader changes in popular culture brought about by rapid scientific and technological advances and widespread dissemination of information about them is a more likely explanation for increased juror expectations and demand for scientific evidence. Part V provides an overview of contemporary perspectives of mass-mediated effects on public attitudes, behaviors, and expectations as a prelude to a suggested Indirect-Effects Model of Mediated Adjudication. The authors propose an indirect-effects model of juror influences that triangulates the potential interactive effects of a CSI effect myth with the likelihood of a tech effect in the context of the mass mediated effects of law and order or crime and justice news media

Chromatin remodeling — a novel strategy to control excessive alcohol drinking

Harmful excessive use of alcohol has a severe impact on society and it remains one of the major causes of morbidity and mortality in the population. However, mechanisms that underlie excessive alcohol consumption are still poorly understood, and thus available medications for alcohol use disorders are limited. Here, we report that changing the level of chromatin condensation by affecting DNA methylation or histone acetylation limits excessive alcohol drinking and seeking behaviors in rodents. Specifically, we show that decreasing DNA methylation by inhibiting the activity of DNA methyltransferase (DNMT) with systemic administration of the FDA-approved drug, 5-azacitidine (5-AzaC) prevents excessive alcohol use in mice. Similarly, we find that increasing histone acetylation via systemic treatment with several histone deacetylase (HDAC) inhibitors reduces mice binge-like alcohol drinking. We further report that systemic administration of the FDA-approved HDAC inhibitor, SAHA, inhibits the motivation of rats to seek alcohol. Importantly, the actions of both DNMT and HDAC inhibitors are specific for alcohol, as no changes in saccharin or sucrose intake were observed. In line with these behavioral findings, we demonstrate that excessive alcohol drinking increases DNMT1 levels and reduces histone H4 acetylation in the nucleus accumbens (NAc) of rodents. Together, our findings illustrate that DNA methylation and histone acetylation control the level of excessive alcohol drinking and seeking behaviors in preclinical rodent models. Our study therefore highlights the possibility that DNMT and HDAC inhibitors can be used to treat harmful alcohol abuse

Media representation of regulated incivilities: Relevant actors, problems, solutions and the role played by experts in the Flemish press

This article analyses the representations of regulated nuisance in a section of Flemish newspapers over time. It identifies the groups of people who have been successful in conveying messages in and through Flemish press news, and explores the way they have represented problems of, and suggested solutions to, regulated incivilities over the years. Furthermore, against the backdrop of newsmaking criminology, it considers whether and how crime and justice experts have contributed to shaping the Flemish media discourse on regulated incivilities over time. Overall the analysis of press news has found that the press, by giving coverage to the voices of local institutional actors, has promoted the criminalization of nuisance and, especially, of physical incivilities. The views of criminological experts, by contrast, have remained marginal. The article concludes by suggesting how such findings present a new set of empirical and conceptual challenges for newsmaking criminology, and more generally, for public criminology

Moduli, Scalar Charges, and the First Law of Black Hole Thermodynamics

We show that under variation of moduli fields $\phi$ the first law of black hole thermodynamics becomes $dM = {\kappa dA\over 8\pi} + \Omega dJ + \psi dq + \chi dp - \Sigma d\phi$, where $\Sigma$ are the scalar charges. We also show that the ADM mass is extremized at fixed $A$, $J$, $(p,q)$ when the moduli fields take the fixed value $\phi_{\rm fix}(p,q)$ which depend only on electric and magnetic charges. It follows that the least mass of any black hole with fixed conserved electric and magnetic charges is given by the mass of the double-extreme black hole with these charges. Our work allows us to interpret the previously established result that for all extreme black holes the moduli fields at the horizon take a value $\phi= \phi_{\rm fix}(p,q)$ depending only on the electric and magnetic conserved charges: $\phi_{\rm fix}(p,q)$ is such that the scalar charges $\Sigma ( \phi_{\rm fix}, (p,q))=0$.Comment: 3 pages, no figures, more detailed versio

Efficient routing of single photons by one atom and a microtoroidal cavity

Single photons from a coherent input are efficiently redirected to a separate output by way of a fiber-coupled microtoroidal cavity interacting with individual Cesium atoms. By operating in an overcoupled regime for the input-output to a tapered fiber, our system functions as a quantum router with high efficiency for photon sorting. Single photons are reflected and excess photons transmitted, as confirmed by observations of photon antibunching (bunching) for the reflected (transmitted) light. Our photon router is robust against large variations of atomic position and input power, with the observed photon antibunching persisting for intracavity photon number 0.03 \lesssim n \lesssim 0.7

Contemporary evaluation of the causes of cardiac tamponade: Acute and long-term outcomes

Background: Cardiac tamponade is a life-threatening state that complicates various medical conditions. The contemporary interventional era may have led to changes in clinical characteristics, causes and outcomes of cardiac tamponade. Methods: We investigated all patients diagnosed with cardiac tamponade, based on clinical and echocardiographic findings, at a single medical center between the years 2000 and 2013. Data on medical history, index hospitalizations, pericardial fluid etiologies, and acute and long-term outcomes were collected. Results: Cardiac tamponade was observed in 83 patients (52% females). Major etiologies included complications of percutaneous cardiac interventions (36%) and malignancies (primarily lung cancer; 23%), infectious/inflammatory causes (15%) and mechanical complications of myocardial infarction (12%). Sixteen (19%) patients died during the index hospitalization. Acute presentation of symptoms and lower quantity of effusion were associated with in-hospital mortality (p = 0.045 and p = 0.007). Tamponade secondary to malignancy was associated with the most substantial increment in post-discharge mortality (from 16% in-hospital to 68% 1-year mortality). During the mean follow-up of 45 months, 39 (45%) patients died. Malignancies, mechanical complications of myocardial infarction and bleeding/coagulation abnormalities were etiologies associated with poor survival (80% mortality during follow-up). Tamponade secondary to complications of percutaneous cardiac interventions or infectious/inflammatory causes were associated with significantly lower mortality (28% and 17%; log rank p < 0.001). Conclusions: In a contemporary cohort, complications of percutaneous cardiac intervention replaced malignant diseases as the leading cause of cardiac tamponade. Nevertheless, these iatrogenic complications were associated with a relatively favorable outcome compared to tamponade induced by complications of myocardial infarction, coagulation abnormalities and malignant diseases.

The prognostic value of the tumour marker Cyfra 21-1 in carcinoma of head and neck and its role in early detection of recurrent disease

This study examines a new tumour marker, Cyfra 21-1, as a prognostic marker in predicting the survival of H&N cancer patients, and its correlation with clinical outcome during prolonged follow up of these patients. The study included 67 patients with primary detection of carcinoma of H&N. The survival of these patients was evaluated in correlation with the disease stage and Cyfra 21-1 levels at initial diagnosis. 38 patients were followed clinically and with serial assays for at least 12 months, or until recurrence was diagnosed. Cyfra 21-1 levels were determined periodically, using an Elisa kit. Patients with Cyfra 21-1 < 1.5 ng ml–1had a higher survival rate compared to patients with Cyfra 21-1 ≥ 1.5 ng ml–1(63% vs. 20%, respectively). The risk ratio of Ln(Cyfra 21-1) is 1.62 (P = 0.028). In a Cox regression model that included the disease stage and Ln(Cyfra 21-1), Ln(Cyfra 21-1) was preferred as the main parameter for predicting patients survival. In 83% of the 12 patients with recurrent or residual disease, Cyfra 21-1 was elevated before or during clinical detection of the recurrence. Cyfra 21-1 was found to be a prognostic marker for carcinoma of H&N, unrelated to the stage of the disease. Elevated levels of Cyfra 21-1 without clinical evidence of disease can be attributed to the marker's mean lead-time as compared to the clinical appearance of the disease. © 2000 Cancer Research Campaign http://www.bjcancer.co