Pharmacological activity of new imidazole-4,5-dicarboxylic acid derivatives in dopaminergic transmission suppression ttests in mice and rats

To study the antiparkinsonian activity of new 1,2-substituted imidazole-4,5-dicarboxylic acids in dopaminergic transmission suppression tests in mice and rat

Investigation of antiparkinsonian activity of new imidazole-4,5-dicarboxylic acid derivatives on the experimental model of catalepsy

To study the antiparkinsonian activity of new ligands of the glutamate NMDA receptor complex -1,2-substituted imidazole-4,5-dicarboxylic acids - on an experimental model of catalepsy caused by haloperidol intraabdominal injections in rat

Screening of powdery mildew resistant barley accessions from Ethiopia for tolerance to abiotic stressors

Background. Analyzing the adaptive potential of cultivated barley with the aim of using new genotypes selected and developed in the process of work is a priority trend in scientific research. The Ethiopian barleys adapted to a variety of soil and climate conditions are characterized by many valuable biological and agronomic traits. Of particular value are genotypes that combine resistance to harmful organisms and environmental stressors.Materials and methods. The collection accessions of Ethiopian barley possessing powdery mildew resistance were studied for tolerance to adverse edaphic factors (chloride salinity and high content of toxic aluminum ions in the soil). Resistance to abiotic stressors was assessed in laboratory experiments. In the study of salt tolerance, a ‘roll-based’ assessment technique was used, which takes into account the inhibition of root growth under salt (NaCl) stress conditions, compared with the reference conditions without salinization. Aluminum sensitivity of barley accessions was diagnosed in the early stages of plant development using the root test.Results and conclusions. A polymorphism of Ethiopian barleys for resistance to adverse edaphic factors was revealed. Twentyone new sources of barley resistance to toxic aluminum ions were identified, of which accessions k-8552 and k-22933 were classified as highly resistant. Accessions k-17554, k-19975, k-20029, k-20048, k-22752, k-23450 and k-25009 proved resistant to soil salinization. Barley accessions k-17554, k-22752 and k-25009 were characterized by complex resistance to powdery mildew, toxic aluminum ions, and chloride soil salinity

Comprehensive approach in treatment of locally disseminated oropharyngeal cancer

The article contains information about current trends of treatment of the locally advanced oropharynx cancer. We analyzed the results of chemoradiation treatment, and surgery treatment of patients with rudimentary tumors after the chemoradiation therapy, taking into account the tumor margin, which gives capacity to perform an adequate operation with good oncological results

Assessment of biodamage resistance of various concrete grades

© 2016, International Journal of Pharmacy and Technology. All rights reserved.At estimation of modern mineral construction materials resistance to Aspergillus niger; Aureobasidium pullulans; Trichoderma sp. it was shown that 28-day exposure of test samples with micromycetes according to GOST 310.4-81 does not reduce their chemical stability coefficient. Analysis of growth rate of selected micromycetes in solid Czapeck-Daux medium allows to relate them to r-strategists. At cultivation of microscopic fungi in liquid Czapeck-Daux medium one-, two-and tribasic (acetic, oxalic, apple and citric) organic acids were identified. High rate of micromycetes growth and formation of wide range of organic acids during their growth gives the basis for supposition that at long-lasting contact of microscopic fungi with construction materials the damage of the latter cannot be excluded

Slow drowning of Tibetan grasslands fenced in by Beijing

The initiative that led to pasture being fenced off is part of a string of Chinese grassland policies. Although Tibet has its own regional government, policies concerning what is called the Tibet Autonomous Region are effectively handed down from the Chinese government in Beijing. This article traces the degradation of grasslands and with it, nomadic culture, due to fencing the land. It is becoming clear that grassland privatization, which was introduced to protect the environment, is causing biodiversity loss and a decline in grassland quality. Due to climate change, meltwater submerges the highlands and snowstorms hit trapped herds; shrinking glaciers defrost soil, increasing flow into mountain lakes

The EU as a Good Global Actor

This paper outlines an exploratory workshop at City Law School, City, University of London funded by HEIF/ ‘EUTIP’ Marie Skłodowska-Curie Innovative Training Network (ITN) on understanding of the EU as a Good Global Actor.1 The EU has as its mission to be a good global governance actor yet is continuously challenged in the world. As a global actor, the EU is both a weak and strong actor in a divergent range of global governance areas. It is not comparable to study the EU as a global trade actor for example to its efforts in human rights, data, cyber or the environment. EU international relations constitutes arguably a booming field of law where the EU appears often to be a victim of its own success. The range of the subjects and objects of EU law continues to expand and the EU is arguably increasingly a victim of its own success, increasingly taking decisions with impacts on third countries or parties, subjecting more entities to sanctions regimes, being bound to consult more entities and have more third countries, parties and entities such as lobbyists interested in the directions of EU law. The assessment of the EU as a global actor includes broad checks on normative action ex ante and ex post facto- yet it is no less harsh. Ex ante metrics of EU global action include court-centred ones such as an opinion from the CJEU on legality of an international agreement, often precluded in most constitutional systems on account of its conflict with pacta sunt servanda. The contours of the principle of the autonomy of EU law have the capacity to put more stringent parameters on EU institutionalised evolutions as to international engagement. How can we assess the EU as a global actor given these realities? The aim of the event was to explore informally the nexus between trade and security, trade and economics and trade and human rights as a future research agenda with input from a variety of scholars It reflected upon four major themes: 1) The EU’s Contribution to the Democratisation of Global Governance 2) Deeper Trade Agreements and New Normative Foundations 3) The EU as a Global Actor in Trade and Fundamental Rights 4) EU’s Trade in the Era of Global Data Flows

2D Spectroscopy of Candidate Polar-Ring Galaxies: I. The Pair of Galaxies UGC 5600/09

Observations of the pair of galaxies VV 330 with the SCORPIO multimode instrument on the 6-m Special Astrophysical Observatory telescope are presented. Large-scale velocity fields of the ionized gas in H-alfa and brightness distributions in continuum and H-alfa have been constructed for both galaxies with the help of a scanning Fabry Perot interferometer. Long-slit spectroscopy is used to study the stellar kinematics. Analysis of the data obtained has revealed a complex structure in each of the pair components. Three kinematic subsystems have been identified in UGC 5600: a stellar disk, an inner gas ring turned with respect to the disk through ~80degrees, and an outer gas disk. The stellar and outer gas disks are noncoplanar. Possible scenarios for the formation of the observed multicomponent kinematic galactic structure are considered, including the case where the large-scale velocity field of the gas is represented by the kinematic model of a disk with a warp. The velocity field in the second galaxy of the pair, UGC 5609, is more regular. A joint analysis of the data on the photometric structure and the velocity field has shown that this is probably a late-type spiral galaxy whose shape is distorted by the gravitational interaction, possibly, with UGC 5600.Comment: 18 pages, 6 figure

NGC 7468: a galaxy with an inner polar disk

We present our spectroscopic observations of the galaxy NGC 7468 performed at the 6-m Special Astrophysical Observatory telescope using the UAGS long-slit spectrograph, the multipupil fiber spectrograph MPFS, and the scanning Fabry-Perot interferometer (IFP). We found no significant deviations from the circular rotation of the galactic disk in the velocity field in the regions of brightness excess along the major axis of the galaxy (the putative polar ring). Thus, these features are either tidal structures or weakly developed spiral arms. However, we detected a gaseous disk at the center of the galaxy whose rotation plane is almost perpendicular to the plane of the galactic disk. The central collision of NGC 7468 with a gas-rich dwarf galaxy and their subsequent merging seem to be responsible for the formation of this disk.Comment: 8 pages, 6 figures, accepted in Astronomy Letters, 2004, vol 30., N 9, p. 58

НИКОЛАЙ ПРОКОФЬЕВИЧ ФЕДОРЕНКО: ТОЧНЫЙ РАСЧЕТ И ПРЕДВИДЕНИЕ

The article is devoted to the 100th anniversary of the birth of Nikolay Prokofyevich Fedorenko, a graduate of M.V. Lomonosov MITHT, a participant of the Great Patriotic War, the head of MITHT department for chemical industry economy (1951-1962), since 1953 to 1958 - the deputy director of MITHT for studies. N.P. Fedorenko is Doctor of Economics, professor, academician of the Academy of Sciences of the USSR, member of the presidium of the Academy of Sciences of the USSR, academician-secretary of the Economy department of the Academy of Sciences of the USSR, one of the main founders and the first director of the Central Economics and Mathematics Institute of the Academy of Sciences of the USSR (1963-1985). N.P. Fedorenko was the most talented organizer of the economic science. He made a large contribution to the chemicalization of the national economy, to the application of modern mathematical methods and computing hardware for economic research, to the planning, management and studying of the theoretical and methodological bases of optimum performance of economy.Статья посвящена 100-летию со дня рождения Николая Прокофьевича Федоренко, выпускника МИТХТ им. М.В. Ломоносова, участника Великой Отечественной войны, заведующего кафедрой экономики химической промышленности МИТХТ (1951-1962 гг.), с 1953 г. по 1958 г. - заместителя директора МИТХТ по учебной работе. Н.П. Федоренко - доктор экономических наук, профессор, академик АН СССР, член президиума АН СССР, академик-секретарь Отделения экономики АН СССР, один из главных основателей и первый директор ЦЭМИ АН СССР (1963-1985), талантливейший организатор экономической науки, внесший крупный вклад в разработку проблем химизации народного хозяйства, в применение современных математических методов и вычислительной техники для экономических исследований, в планирование, управление, изучение теоретических и методологических основ оптимального функционирования экономики