Reactions of p-Nitrophenyloxirane with Amines Containing Fragments with Bicyclic Skeleton

Reactions of p-nitrophenyloxirane with amines containing fragments with bicyclic skeleton of norbornene, norbornane, epoxynorbornane (stereoisomeric exo- and endo-5-aminomethylbicyclo[2.2.1]hept-2-enes, N-benzyl-endo-5-aminomethylbicyclo[2.2.1]hept-2-ene, endo-5-(2-aminoethyl)bicyclo[2.2.1]hept-2-ene, stereoisomeric exo- and endo-2-aminomethylbicyclo[2.2.1]heptanes, 2-(1-aminoethyl)bicyclo[2.2.1]-heptane, exo-5-aminomethyl-exo-2,3-epoxybicyclo[2.2.1]heptane) were investigated. The aminolysis of pnitrophenyloxirane occurred regioselectively according to Krasusky rule as was proved by 1H and 13C NMR data. As shown by 1H and 13C NMR spectroscopy the oxyalkylation product obtained from N-benzyl-endo-5-aminomethylbicyclo[2.2.1]hept-2-ene was composed of two diastereomers originating from the presence of a chiral nitrogen atom in the rear part of the rigid bicyclic skeleton. New products of amino groups transformation in the molecules of hydroxyamines were obtained by reaction with p-methylbenzoyl chloride and p-nitrophenylsulfonyl chloride. Regioselectivity of the attack of electrophilic reagents on the nitrogen in the hydroxyamines was confirmed by IR and 1H NMR spectra of the products. The data on pharmacological activity tests of N-2-hydroxyethyl(p-nitrophenyl)-5-aminomethylbicyclo[2.2.1]hept-2-ene are reported

The origin of seed photons for Comptonization in the black hole binary Swift J1753.5-0127

Aims. The black hole binary SWIFT J1753.5-0127 is providing a unique data set to study accretion flows. Various investigations of this system and of other black holes have not, however, led to an agreement on the accretion flow geometry or on the seed photon source for Comptonization during different stages of X-ray outbursts. We place constraints on these accretion flow properties by studying long-term spectral variations of this source. Methods. We performed phenomenological and self-consistent broad band spectral modeling of Swift J1753.5-0127 using quasi-simultaneous archived data from INTEGRAL/ISGRI, Swift/UVOT/XRT/BAT, RXTE/PCA/HEXTE and MAXI/GSC instruments. Results. We identify a critical flux limit, F \sim 1.5 \times 10^{-8} erg/cm^2/s, and show that the spectral properties of SWIFT J1753.5-0127 are markedly different above and below this value. Above the limit, during the outburst peak, the hot medium seems to intercept roughly 50 percent of the disk emission. Below it, in the outburst tail, the contribution of the disk photons reduces significantly and the entire spectrum from the optical to X-rays can be produced by a synchrotron-self-Compton mechanism. The long-term variations in the hard X-ray spectra are caused by erratic changes of the electron temperatures in the hot medium. Thermal Comptonization models indicate unreasonably low hot medium optical depths during the short incursions into the soft state after 2010, suggesting that non-thermal electrons produce the Comptonized tail in this state. The soft X-ray excess, likely produced by the accretion disk, shows peculiarly stable temperatures for over an order of magnitude changes in flux. Conclusions. The long-term spectral trends of SWIFT J1753.5-0127 are likely set by variations of the truncation radius and a formation of a hot, quasi-spherical inner flow in the vicinity of the black hole. (abridged)Comment: 16 pages, 8 figures, published in A&

Spectral analysis of X-ray pulsars with the INTEGRAL observatory

We studied spectra for 34 accretion-powered X-ray and one millisecond pulsars that were within the field of view of the INTEGRAL observatory over two years (December 2002 - January 2005) of its in-orbit operation and that were detected by its instruments at a statistically significant level (>8 sigma in the energy range 18-60 keV). There are seven recently discovered objects of this class among the pulsars studied: 2RXP J130159.6-635806, IGR/AX J16320-4751, IGR J16358-4726, AX J163904-4642, IGR J16465-4507, SAX/IGR J18027-2017 and AX J1841.0-0535. We analyze the evolution of spectral parameters as a function of the intensity of the sources and compare these with the results of previous studies

A comparison of hydrogen photoproduction by sulfur-deprived Chlamydomonas reinhardtii under different growth conditions

Continuous photoproduction of H-2 by the green alga, Chlamydomonas reinhardtii, is observed after incubating the cultures for about a day in the absence of sulfate and in the presence of acetate. Sulfur deprivation causes the partial and reversible inactivation of photosynthetic O-2 evolution in algae, resulting in the light-induced establishment of anaerobic conditions in sealed photobioreactors, expression of two [FeFe]-hydrogenases in the cells, and H-2 photoproduction for several days. We have previously demonstrated that sulfur-deprived algal cultures can produce H-2 gas in the absence of acetate, when appropriate experimental protocols were used (Tsygankov, A.A., Kosourov, S.N., Tolstygina, IN., Ghirardi, M.L., Seibert, M., 2006. Hydrogen production by sulfur-deprived Chlamydomonas reinhardtii under photoautotrophic conditions. Int. J. Hydrogen Energy 31, 1574-1584). We now report the use of an automated photobioreactor system to compare the effects of photoautotrophic, photoheterotrophic and photomixotrophic growth conditions on the kinetic parameters associated with the adaptation of the algal cells to sulfur deprivation and H-2 photoproduction. This was done under the experimental conditions outlined in the above reference, including controlled pH. From this comparison we show that both acetate and CO2 are required for the most rapid inactivation of photosystem II and the highest yield of H-2 gas production. Although, the presence of acetate in the system is not critical for the process, H-2 photoproduction under photoautotrophic conditions can be increased by optimizing the conditions for high starch accumulation. These results suggest ways of engineering algae to improve H-2 production, which in turn may have a positive impact on the economics of applied systems for H,, production. (c) 2007 Elsevier B.V. All rights reserved

Expanding hot flow in the black hole binary SWIFT J1753.5-0127: evidence from optical timing

We describe the evolution of optical and X-ray temporal characteristics during the outburst decline of the black hole X-ray binary SWIFT J1753.5-0127. The optical/X-ray cross-correlation function demonstrates a single positive correlation at the outburst peak, then it has multiple dips and peaks during the decline stage, which are then replaced by the precognition dip plus peak structure in the outburst tail. Power spectral densities and phase lags show a complex evolution, revealing the presence of intrinsically connected optical and X-ray quasi-periodic oscillations. For the first time, we quantitatively explain the evolution of these timing properties during the entire outburst within one model, the essence of which is the expansion of the hot accretion flow towards the tail of the outburst. The pivoting of the spectrum produced by synchrotron Comptonization in the hot flow is responsible for the appearance of the anti-correlation with the X-rays and for the optical quasi-periodic oscillations. Our model reproduces well the cross-correlation and phase lag spectrum during the decline stage, which could not be understood with any model proposed before.Comment: 13 pages, 11 figures, MNRAS submitte

V0332+53 in the outburst of 2004--2005: luminosity dependence of the cyclotron line and pulse profile

We present results of observations of the transient X-ray pulsar V0332+53 performed during a very powerful outburst in Dec, 2004 -- Feb, 2005 with the INTEGRAL and RXTE observatories in a wide (3-100 keV) energy band. A cyclotron resonance scattering line at an energy of ~26 keV has been detected in the source spectrum together with its two higher harmonics at ~50 and ~73 keV, respectively. We show that the energy of the line is not constant but linearly changes with the source luminosity. Strong pulse profile variations, especially near the cyclotron line, are revealed for different levels of the source intensity. We discuss the obtained results in terms of the theoretical models of X-ray pulsars.Comment: Accepted for publication in MNRAS. 10 pages, 9 figure

N,N-Dimethoxy-N-tert-alkylamines: new synthesis methods and the crystal structure of the precursor

Under the methanolysis of N-methoxy-N-(1-pyridinium)amines salts 1a–c, nucleophilic substitution occurs at the nitrogen atom to form N,N-dimethoxyamines 2a,b; the crystal structure of precursor 1c has been studied