The development of the posterity of male and female outbred rats exposed to sublimate

Mercury has gonadotropic and mutagenic effects on the Mammalia organism. This fact indicates the possibility of appearance of the mercury exposure effects on the offspring whose parents were exposed to this toxicant. The sublimate effects on the development of the first generation offspring from male and female outbred rats exposed to this substance were studied. Sublimate solution. (0,05 mg of mercury for 100 g of animal's body weight) was injected subcutaneously to outbred rats during 6 weeks. After ending of the injections these rats were mated with intact rats for getting the posterity. The examination of albino rats posterity had two stages. The first stage was to study the development of sensor-motional reactions on the first and. the tenth days of life. The second stage included the research of zoosocial behavior of sexually mature rats and. their activity in open field. Also the posterity was weighted for estimation of physical development. Obtained, materials of the researches were elaborated with use of methods of nonparametric statistics (Mann — Whitney U-criteria). At the analysis of the results of the experiment we revealed statistically significant differences in body weight and. motive activity of animals of experimental group in comparison with control group. Decrease of body weight in posterity of experimental male rats was revealed and. there were no differences in maturation of sensor-motional reflexes in their first days of life. Increase of body weight and motional activity was revealed in posterity of female rats with sublimate intoxication in comparison with control values. Changes of body weight and. behavior were registered in sexually mature posterity. Increase of body weight in comparison with control group was registered at the weighing of experimental animals. Depression of motive, position-finding, research and zoosocial activity was revealed in posterity of experimental male rats. Depression of motive, position-finding and. research activity was revealed in male posterity of experimental female rats and. strengthening of position-finding and. research activity was revealed in their female posterity

Grammar, semantics, and usage in a dynamic relation: The use of the construction ‘verb with prefix pod- + accusative’ on the basis of the RNC

© 2017 Springer Science+Business Media DordrechtThe article analyses the use of the construction ‘verb with the prefix pod- plus noun in the accusative without a preposition’ (pod-V + NAcc) based on data taken from the Russian National Corpus (RNC). The study included the analysis of over 2000 examples of this construction in use. It concentrates on developing a methodology for the semantic and grammatical analysis on the basis of a vast range of material. The verbs were analyzed with regard to their grammatical structure and semantic classification. The interaction between the characteristics of the prefix and the verb stem has been illustrated with the help of the grammatical categories of transitivity and reflexivity. This means that the prefix functions as a relator that changes the conceptualization of a situation. The data from the RNC were used to demonstrate and update the classification of the meanings of pod- previously suggested by V. Plungjan. The notion of radial categories was used to demonstrate the relationship between the different meanings of this prefix

Power spectrum features of the near-Earth atmospheric electric field in Kamchatka

Power spectrum of the diurnal variations of the quasi-electrostatic field Ez in the near-Earth atmosphere have been presented for the first time. The Ez power spectrum variations in the period of fine weather have been shown to exhibit two bands of the periods of natural atmospheric oscillations with T = 1-5 and 6-24 h. These oscillations are the modes of the internal gravity and tidal waves in the lower atmosphere. On the days under atmospheric precipitation, the spectral power of Ez increases by an order of magnitude. During the pre-earthquake period, when the diurnal Ez variation had an anomaly, the intensity of harmonics with T = 1.8, 2.2, and 3.8 h increased by an order of magnitude or more in comparison with the Ez spectra in fine weather. Two additional spectral bands with T = 0.6 and 1 h have appeared simultaneously

Aging Challenges. Perceived Age – a New Predictor of Longevity?

The ageing process is accompanied by the manifestation of many characteristics, so-called biomarkers, which can be quantified and used to assess a patient's health status. One of these signs is the progressive decline of a human's facial look, which is described by the concept of 'perceived age'. Facial aging is the most important parameter of perceived age. However, over the years, researchers have identified risk factors that affect the facial skin, including smoking, systematic consumption of alcoholic beverages, overweight or underweight, environmental conditions, and psychosocial determinants. The influence of psychological state on the appearance and life prognosis is shown. The authors presented data from the international literature on the study of perceived age. The frontiers of using perceived age as a biomarker of aging were Danish scientists who developed the main methodological approaches to determine this indicator. One such methodology used in population studies has been the clinical technique of assessing perceived age through photography. The review presents this methodology in detail, with its advantages and modifications. The authors conclude that the measurement of an individual's perceived age can serve not only as a prognostic indicator,  but also over time can become a   useful marker of the effectiveness of various treatments. Until now perceived age has hardly been studied in population studies, the authors presented data from the works of V.A.  Labunskaya, G.V.  Serikov,  T.A.  Shkurko who develop the direction related to psychology of perceived age  and in their studies use social-psychological approaches of appearance assessment

Pathogenic characteristics of intracellular infection in chlamydiosis

This review analyzes scientific data and systematized information regarding microbiological aspects and pathogenesis of chlamydia infection. Chlamydia are obligate intracellular microorganisms that are sensitive to any human cells where energy parasitism is possible: various types of epithelium, fibrocytes, histiocytes, glial and muscle cells, squamous epithelium of the meninges and eyeball, neurons, monocytes, macrophages. Structure, chemical composition and enzymatic activity of Chlamydia closely resemble those in Gram-negative bacteria, as they retain their morphological identity throughout the life cycle, possess cell wall, ribosomes, DNA, RNA, biochemical elements of glycolysis, tissue respiration, peptose production being sensitive to some broad-spectrum antibiotics, and are able to vegetative form division. In recent decades, the pathogenesis and clinical symptoms of chlamydial lesions in the urogenital tract, nervous, cardiovascular, musculoskeletal and bronchopulmonary systems have been actively studied, and new approaches and treatment schemes for chlamydia-infected patients are still developing. Over many decades, Chlamydia infection has been an important and urgent problem, not only due to its high prevalence, but also because of high rate of complications negatively affecting populational health and related demographic parameters. Chlamydia causes multiple diseases resulting in chronization of inflammatory process in all human organs and systems, and affects reproduction of population. Mandatory statistical recording of chlamydiosis cases introduced as early as in 1994 in the Russian Federation does not reflect the actual incidence rate. A rise in number of inflammatory diseases of the upper respiratory tract caused by Chlamydia undoubtedly increases its etiological importance, but data regarding etiopathogenetic role of Chlamydia in ENT pathology are ambiguous and contradictory. Available publications describe a large range of variation in rate of detected Chlamydia due to poor awareness of doctors about the microbiological properties of chlamydia, pathogenetic and clinical features of clinical signs of this infection, and lack of common and clear understanding on the algorithms for identifying and treating chlamydiosis. Since the majority of chlamydia-associated nosological forms are asymptomatic, knowing pathogenetic features of related will allow to prevent the spread of the infection and reduce subsequent socio-economic consequences

On the Question of the Formation of the Personnel Policy of the Educational Organization

The article describes the features of formation of personnel policy in the educational institution. The essence of the personnel policy work with the personnel corresponding to the concept of educational organization, ie the personnel policy of any educational institution - is an integral part of the strategic policy oriented organization. Personnel policy is a powerful strategic tool for the staff of the organization management system.Сутью кадровой политики является работа с персоналом, соответствующая концепции развития образовательной организации, то есть кадровая политика любого учебного учреждения – это составная часть стратегически ориентированной политики организации. Кадровая политика является мощным стратегическим инструментом системы управления персоналом организации

From experimental biomodeling to personalized medicine

This article presents the results of experimental studies of adverse effects of environmental and occupational exposures on the morphofunctional state of the central nervous system in offspring rats. The results of this study show that newborn offspring of rats exposed to vinyl chloride and mercuric chloride lagged behind the controls in sensory-motor development. There was violated the whole structure of behavior in adult offspring characterized by reduces motor and exploratory activity, increased anxiety in rats. There was abnormal impulse conduction in the neuromuscular apparatus of the hind legs of albino rats and morphological changes in the structure of nervous tissue. Developmental disorders in the offspring may be associated with the processes of accumulation, influence on the genetic apparatus of cells or mediated by epigenetic mechanisms of CNS disorders. A comparative study of the behavioral and cognitive effects of toluene, cerebral bioelectrical activity in rats with a normal embryogenesis and background prenatal hypoxia has been found that toluene neurotoxicity are more pronounced in adult rats exposed to chronic prenatal hypoxia. The results suggest a possible decrease in the sensitivity of neurons to the action of neurotoxicants because of prenatal hypoxic damage. The significance of experimental modeling is to develop approaches to personalized medicine, because knowledge of the previous prenatal pathology or neurointoxication of parents allow study of individual measures of prevention, treatment, and decisions about employment of the younger generation

International trends in the justice digitalization development

The authors substantiate the feasibility of introducing digital technology into the modern system of administration of justice. It is noted that the introduction of digital technologies will reduce the time for disposal of legal proceedings, create an independent, but at the same time transparent judicial system, improve the quality of decisions taken by the court and the level of public confidence in the state, and minimize government spending in this are

HEALTHCARE RESOURCES UTILIZATION AND TEMPORARY DISABILITY IN POPULATION AGED 50-64 ACCORDING TO THE EPIDEMIOLOGICAL ESSE-RF STUDY

Aim. To analyze health care resource utilization and temporary disability in people of pre-retirement age in the Russian population.Material and methods. The analysis was carried out on the basis of the ESSE-RF study materials (13 regions of the RF). Standard epidemiological survey methods and evaluation criteria were used. The analysis included results of a survey of the ESSE-RF study participants about health care resource utilization and temporary disability (TD) during 12 months before the survey. The following characteristics were ascertained: a number and reasons of outpatient visits for medical assistance, hospital admissions (including duration of in-hospital treatment), emergency calls and temporary disability (a number of days and cases), their mean number per one study participant, mean number of cases and days of TD per 100 working participants, associations with social-demographic parameters, risk factors, chronic non-communicable diseases, stress and anxiety levels by the Hospital Anxiety and Depression Scale (HADS).Results. A total of 8334 people aged 50-64 years were examined: men – 2784 (33%) and women – 5550 (67%). A share of the hospitalized (at least one time) was 11% in the age group of 50-54 years, 12% – in the age group of 55-59 years and by the age of 60-64 this indicator increased to 15%. 20% of the participants at least one time were admitted to hospital and/or called an ambulance. A share of people who had utilized health care resources at least one time was increasing with age. Unemployed people were hospitalized more frequently than employed ones. Number of chronic non-communicable diseases correlated with the probability of hospitalization and/or emergency call. Categories 2 and 3 of disability, presence of diabetes mellitus, ischemic heart disease and hypertension were statistically significantly associated with the probability of hospitalization and/or emergency call. Smoking did not increase the probability of hospitalization and/or emergency call in comparison with absence of this risk factor, at that, people who had given up smoking were 1.3 times more likely to be hospitalized than non-smokers. People with low and moderate alcohol consumption were hospitalized and called an ambulance significantly less often than those who abstained from alcohol. Clinically significant anxiety increased the probability of hospital admission and/or emergency call as compared to people without this factor by the HADS. Subclinical and clinically significant anxiety, mean and high levels of stress were associated with the probability of hospitalization and/or emergency call. Number of TD days turned out to be rather low - 0.3 day per 1 working man and 0.4 day - per 1 working woman, this index did not significantly differ with age.Conclusion. So, pre-retirement age (50-64 years) is characterized by increase in health care resource utilization due to health state worsening. At the same time significant share of people of this age (40%) did not seek medical help. These 40% of pre-retirement age people can be possible reserve for health state improvement by means of their active involvement in preventive activity of primary health care system (the study had been conducted before the preventive medical examination program starting)

ЧАСТОТА ВЫЯВЛЕНИЯ ХЛАМИДИЙ В НОСОГЛОТКЕ У ШКОЛЬНИКОВ С ПОМОЩЬЮ МЕТОДА ПРЯМОЙ ИММУНОФЛЮОРЕСЦЕНЦИИ

The article presents information on the prevalence of chlamydial infection of the upper respiratory tract in schoolchildren. Researchers have shown specific structure of the identified chlamydia depending on gender and age of the patients, as well as the prevalence of children with positive chlamydial antigens of acute and of chronic upper respiratory disease, compared with uninfected children. These results are based on a survey of 708 schoolchildren between the ages of 7 and 14 years. Chlamydia diagnosis was performed by direct immunofluorescence. В статье представлены сведения о распространенности хламидийного инфицирования верхнего отдела респираторного тракта у школьников. Исследователями показана видовая структура идентифицированных хламидий в зависимости от пола и возраста, а также превалирование у детей с положительными хламидийными антигенами острой и хронической ЛОР-патологии, по сравнению с неинфицированными детьми. Полученные результаты базируются на обследовании 708 школьников в возрасте от 7 до 14 лет включительно. Диагностика хламидий осуществлялась методом прямой иммунофлюоресценции.