23 research outputs found
Correction of Experimental Retinal Ischemia by L-Isomer of Ethylmethylhydroxypyridine Malate
An important task of pharmacology and ophtalmology is to find specific and highly effective agents for correcting retinal ischemia. The objective of this study is to increase the effectiveness of pharmacological correction of retinal ischemia by using new 3-hydroxypyridine derivative-L-isomer of ethylmethylhydroxypyridine malat
Interleukin-6 is a potential target for a correction of endothelial dysfunction associated with low-grade systemic inflammation
One of pathogenetic links of development of endothelial dysfunction, as an early marker of cardiovascular disease and comorbidity, is a low-grade systemic inflammation. In this regard, correction of cytokines imbalance is one of the possible ways of prevention and treatment of major chronic noninfectious diseases. To study the endothelium protective effects of anti-IL-6 receptor monoclonal antibodies tocilizumab in experimental preclinical studies in a model of endothelial dysfunction associated with the low-grade systemic inflammatio
Molecular screening of prospective candidates for TRPAβ ion channel selective antagonists
Using the molecular modeling techniques, we analyzed spectra of biological activity of a series of promising candidates for selective antagonists of TRPAβ ion channel in order to find potentially active compounds against pain and inflammatio
Retinoprotective effects of non-selective imidazoline receptor agonists
Current drug therapy of ophtalmic diseases associated with retinal ischemia is not always successful enough that ensures the relevance of the search of new effective drug
Ion channel TRPAβ is a promising therapeutic target for treatment of pain
In the last time information about the role of TRPAβ in pain and cold sensitivity, as well as in the formation and maintenance of inflammation is increasing in scientific literature. Given this information, the interest for search and study of pharmacological agents, which selectively blocked of TRPAβ and reduced the severity of pain and inflammation is increasin
Preclinical study of pharmacological activity of enterosorbente on the basis of montmorillonite
At present, enterosorbents based on mineral raw materials are in high demand among the population. However, there are no enterosorbents on the Russian pharmaceutical market on the basis of domestic mineral raw materials, to study the pharmacological activity of enterosorbent based on montmorillonite of Russian origin under experimental conditions. The methodological approach was based on the implementation of a complex of theoretical, pharmacological, toxicological, histological, biochemical, statistical methods. Models of experimental diarrhea, acute and toxic liver damage, acute experimental pancreatitis were selecte
Studies to elucidate the effect and antiapoptotic mechanism of 2-ethyl-3-hydroxy-6- methylpyridine-n-acetyltaurinate in a rat model of retinal ischemia-reperfusion
To study the retinoprotective effect and antiapoptotic mechanism of 2-Ethyl-3-hydroxy-6-methyl-pyridine-Nacetyltaurinate (EHMP-NAT) in a rat model of retinal ischemia-reperfusio
Erythropoietin mimetic peptide (pHBSP) corrects endothelial dysfunction in a rat model of preeclampsia
Preeclampsia is a severe disease of late pregnancy. Etiological factors and a pathogenetic pattern of events still require significant clarification, but it is now recognized that a large role is played by placentation disorders and emerging endothelial dysfunction. The administration of short-chain peptides mimicking the spatial structure of the B erythropoietin chain may become one of the directions of searching for new drugs for preeclampsia prevention and therap
ΠΡΠ³ΠΈΠ½Π°Π·Π° II - Π½ΠΎΠ²Π°Ρ ΠΌΠΈΡΠ΅Π½Ρ Π΄Π»Ρ ΡΠΎΠ·Π΄Π°Π½ΠΈΡ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠΎΠΏΡΠΎΡΠ΅ΠΊΡΠΎΡΠΎΠ²
The article describes arginaseβs role in pathogenesis of endothelial dysfunction and a number of cardio-vascular diseases. Arginase catalyzes the hydrolysis of L-arginine, the substrate for nitric oxide synthesis, to L-ornithine and urea. Two isoforms of arginase were found in the human organism. Arginase I is located in the cells cytoplasm and is predominantly expressed in the liver. Arginase II is a mitochondrial protein that is expressed in the kidney, prostatic gland and vascular wall. Arginase II hydrolyzes L-arginine, thereby reducing the synthesis of nitric oxide and leading to the development of endothelial dysfunction and a number of cardio-vascular disorders. Arginase is a promising pharmacological target in the treatment of endothelial dysfunction and a number of cardio-vascular diseases, though the development of highly-selective arginase II inhibitors is still a difficult task.Π ΠΎΠ±Π·ΠΎΡΠ΅ ΡΠ°ΡΡΠΌΠΎΡΡΠ΅Π½Π° ΡΠΎΠ»Ρ Π°ΡΠ³ΠΈΠ½Π°Π·Ρ Π² ΠΏΠ°ΡΠΎΠ³Π΅Π½Π΅Π·Π΅ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΠΈ ΠΈ ΡΡΠ΄Π° ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎ-ΡΠΎΡΡΠ΄ΠΈΡΡΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ. ΠΡΠ³ΠΈΠ½Π°Π·Π° ΠΊΠ°ΡΠ°Π»ΠΈΠ·ΠΈΡΡΠ΅Ρ Π³ΠΈΠ΄ΡΠΎΠ»ΠΈΠ· L-Π°ΡΠ³ΠΈΠ½ΠΈΠ½Π°, ΡΡΠ±ΡΡΡΠ°ΡΠ° Π΄Π»Ρ ΡΠΈΠ½ΡΠ΅Π·Π° ΠΎΠΊΡΠΈΠ΄Π° Π°Π·ΠΎΡΠ°, Π΄ΠΎ L-ΠΎΡΠ½ΠΈΡΠΈΠ½Π° ΠΈ ΠΌΠΎΡΠ΅Π²ΠΈΠ½Ρ. Π ΠΎΡΠ³Π°Π½ΠΈΠ·ΠΌΠ΅ ΡΠ΅Π»ΠΎΠ²Π΅ΠΊΠ° ΠΎΠ±Π½Π°ΡΡΠΆΠ΅Π½Ρ Π΄Π²Π΅ ΠΈΠ·ΠΎΡΠΎΡΠΌΡ Π°ΡΠ³ΠΈΠ½Π°Π·Ρ. ΠΡΠ³ΠΈΠ½Π°Π·Π° I Π»ΠΎΠΊΠ°Π»ΠΈΠ·ΡΠ΅ΡΡΡ Π² ΡΠΈΡΠΎΠΏΠ»Π°Π·ΠΌΠ΅ ΠΊΠ»Π΅ΡΠΎΠΊ ΠΈ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΡΠ΅ΡΡΡ ΠΏΡΠ΅ΠΈΠΌΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ Π² ΠΏΠ΅ΡΠ΅Π½ΠΈ. ΠΡΠ³ΠΈΠ½Π°Π·Π° II - ΡΡΠΎ ΠΌΠΈΡΠΎΡ
ΠΎΠ½Π΄ΡΠΈΠ°Π»ΡΠ½ΡΠΉ Π±Π΅Π»ΠΎΠΊ, ΠΊΠΎΡΠΎΡΡΠΉ ΡΠΊΡΠΏΡΠ΅ΡΡΠΈΡΡΠ΅ΡΡΡ Π² ΠΏΠΎΡΠΊΠ°Ρ
, ΠΏΡΠΎΡΡΠ°ΡΠ΅, ΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠΉ ΡΡΠ΅Π½ΠΊΠ΅. ΠΡΠ³ΠΈΠ½Π°Π·Π° II Π³ΠΈΠ΄ΡΠΎΠ»ΠΈΠ·ΠΈΡΡΠ΅Ρ L-Π°ΡΠ³ΠΈΠ½ΠΈΠ½, ΡΠ½ΠΈΠΆΠ°Ρ ΡΠ΅ΠΌ ΡΠ°ΠΌΡΠΌ ΡΠΈΠ½ΡΠ΅Π· ΠΎΠΊΡΠΈΠ΄Π° Π°Π·ΠΎΡΠ°, ΠΏΡΠΈΠ²ΠΎΠ΄ΠΈΡ ΠΊ ΡΠ°Π·Π²ΠΈΡΠΈΡ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΠΈ ΠΈ Π²ΠΎΠ·Π½ΠΈΠΊΠ½ΠΎΠ²Π΅Π½ΠΈΡ ΡΠ΅Π»ΠΎΠ³ΠΎ ΡΡΠ΄Π° ΠΏΠ°ΡΠΎΠ»ΠΎΠ³ΠΈΠΉ ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎ-ΡΠΎΡΡΠ΄ΠΈΡΡΠΎΠΉ ΡΠΈΡΡΠ΅ΠΌΡ. ΠΡΠ³ΠΈΠ½Π°Π·Π° ΡΠ²Π»ΡΠ΅ΡΡΡ ΠΏΠ΅ΡΡΠΏΠ΅ΠΊΡΠΈΠ²Π½ΠΎΠΉ ΡΠ°ΡΠΌΠ°ΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΎΠΉ ΠΌΠΈΡΠ΅Π½ΡΡ Π² ΠΊΠΎΡΡΠ΅ΠΊΡΠΈΠΈ ΡΠ½Π΄ΠΎΡΠ΅Π»ΠΈΠ°Π»ΡΠ½ΠΎΠΉ Π΄ΠΈΡΡΡΠ½ΠΊΡΠΈΠΈ ΠΈ ΡΠ΅Π»ΠΎΠ³ΠΎ ΡΡΠ΄Π° ΡΠ΅ΡΠ΄Π΅ΡΠ½ΠΎ-ΡΠΎΡΡΠ΄ΠΈΡΡΡΡ
Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, ΠΎΠ΄Π½Π°ΠΊΠΎ ΡΠΎΠ·Π΄Π°Π½ΠΈΠ΅ Π²ΡΡΠΎΠΊΠΎΡΠ΅Π»Π΅ΠΊΡΠΈΠ²Π½ΡΡ
ΠΈΠ½Π³ΠΈΠ±ΠΈΡΠΎΡΠΎΠ² Π°ΡΠ³ΠΈΠ½Π°Π·Ρ II ΠΏΠΎ-ΠΏΡΠ΅ΠΆΠ½Π΅ΠΌΡ ΠΎΡΡΠ°Π΅ΡΡΡ ΡΡΡΠ΄Π½ΠΎΡΠ°Π·ΡΠ΅ΡΠΈΠΌΠΎΠΉ Π·Π°Π΄Π°ΡΠ΅
Interleukin-6 is a potential target for a correction of endothelial dysfunction associated with low-grade systemic inflammation
One of pathogenetic links of development of endothelial dysfunction, as an early marker of cardiovascular disease and comorbidity, is a low-grade systemic inflammation. In this regard, correction of cytokines imbalance is one of the possible ways of prevention and treatment of major chronic noninfectious diseases. To study the endothelium protective effects of anti-IL-6 receptor monoclonal antibodies tocilizumab in experimental preclinical studies in a model of endothelial dysfunction associated with the low-grade systemic inflammatio