541 research outputs found
On the c-axis optical reflectivity of layered cuprate superconductors
Using a conventional BCS -- Fermi liquid model we calculate the c-axis
optical reflectivity of the layered high temperature cuprate superconductors by
obtaining the finite temperature dynamical dielectric function in a microscopic
self-consistent gauge invariant formalism. We get good semi-quantitative
agreement with all the existing experimental data by using the measured normal
state resistivities as the input parameters in obtaining the c-axis
hopping amplitude and the normal state level broadening in our microscopic
calculation.Comment: 10 pages, 6 figures, 1 table gzipped tar fil
Theory for Dynamical Short Range Order and Fermi Surface Volume in Strongly Correlated Systems
Using the fluctuation exchange approximation of the one band Hubbard model,
we discuss the origin of the changing Fermi surface volume in underdoped
cuprate systems due to the transfer of occupied states from the Fermi surface
to its shadow, resulting from the strong dynamical antiferromagnetic short
range correlations. The momentum and temperature dependence of the quasi
particle scattering rate shows unusual deviations from the conventional Fermi
liquid like behavior. Their consequences for the changing Fermi surface volume
are discussed. Here, we investigate in detail which scattering processes
might be responsible for a violation of the Luttinger theorem. Finally, we
discuss the formation of hole pockets near half filling.Comment: 5 pages, Revtex, 4 postscript figure
Antiferromagnetic Interactions and the Superconducting Gap Function
Spin-fluctuation-mediated superconductivity is conventionally associated with
d_{x^2-y^2} pairing. We show that a generalized model of antiferromagnetic spin
fluctuations in three dimensions may also yield a state with formal ``s-wave''
(A_{1g}) symmetry but with line nodes at k_z \approx \pm \pi / 2c. We study
this new state within both BCS and Eliashberg theories using a realistic band
structure and find that it is more stable than the d_{x^2-y^2} (B_{1g}) state
over a wide range of parameters. Thus, models of spin-fluctuation-mediated
superconductivity must consider both possibilities on an equal footing.Comment: 4 pages, RevTeX with psfig, 2 PostScript figures included in
compressed form, one color PostScript figure available by request to
[email protected] or [email protected]. Minor changes and updated
references from original postin
L-DOPA increases slow-wave sleep duration and selectively modulates memory persistence in older adults
INTRODUCTION: Millions of people worldwide take medications such as L-DOPA that increase dopamine to treat Parkinson's disease. Yet, we do not fully understand how L-DOPA affects sleep and memory. Our earlier research in Parkinson's disease revealed that the timing of L-DOPA relative to sleep affects dopamine's impact on long-term memory. Dopamine projections between the midbrain and hippocampus potentially support memory processes during slow wave sleep. In this study, we aimed to test the hypothesis that L-DOPA enhances memory consolidation by modulating NREM sleep. METHODS: We conducted a double-blind, randomised, placebo-controlled crossover trial with healthy older adults (65-79 years, n = 35). Participants first learned a word list and were then administered long-acting L-DOPA (or placebo) before a full night of sleep. Before sleeping, a proportion of the words were re-exposed using a recognition test to strengthen memory. L-DOPA was active during sleep and the practice-recognition test, but not during initial learning. RESULTS: The single dose of L-DOPA increased total slow-wave sleep duration by approximately 11% compared to placebo, while also increasing spindle amplitudes around slow oscillation peaks and around 1-4 Hz NREM spectral power. However, behaviourally, L-DOPA worsened memory of words presented only once compared to re-exposed words. The coupling of spindles to slow oscillation peaks correlated with these differential effects on weaker and stronger memories. To gauge whether L-DOPA affects encoding or retrieval of information in addition to consolidation, we conducted a second experiment targeting L-DOPA only to initial encoding or retrieval and found no behavioural effects. DISCUSSION: Our results demonstrate that L-DOPA augments slow wave sleep in elderly, perhaps tuning coordinated network activity and impacting the selection of information for long-term storage. The pharmaceutical modification of slow-wave sleep and long-term memory may have clinical implications. CLINICAL TRIAL REGISTRATION: Eudract number: 2015-002027-26; https://doi.org/10.1186/ISRCTN90897064, ISRCTN90897064
The helicity amplitudes A and A for the D resonance obtained from the reaction}
The helicity dependence of the reaction
has been measured for the first time in the photon energy range from 550 to 790
MeV. The experiment, performed at the Mainz microtron MAMI, used a
4-detector system, a circularly polarized, tagged photon beam, and a
longitudinally polarized frozen-spin target. These data are predominantly
sensitive to the resonance and are used to determine its
parameters.Comment: 5 pages, 4 figure
First measurement of the Gerasimov-Drell-Hearn integral for Hydrogen from 200 to 800 MeV
A direct measurement of the helicity dependence of the total photoabsorption
cross section on the proton was carried out at MAMI (Mainz) in the energy range
200 < E_gamma < 800 MeV. The experiment used a 4 detection system, a
circularly polarized tagged photon beam and a frozen spin target.
The contributions to the Gerasimov-Drell-Hearn sum rule and to the forward
spin polarizability determined from the data are 226 \pm 5 (stat)\pm
12(sys) \mu b and -187 \pm 8 (stat)\pm 10(sys)10^{-6} fm^4, respectively, for
200 < E_\gamma < 800 MeV.Comment: 6 pages, 3 figures, 3 table
Faithful Squashed Entanglement
Squashed entanglement is a measure for the entanglement of bipartite quantum
states. In this paper we present a lower bound for squashed entanglement in
terms of a distance to the set of separable states. This implies that squashed
entanglement is faithful, that is, strictly positive if and only if the state
is entangled. We derive the bound on squashed entanglement from a bound on
quantum conditional mutual information, which is used to define squashed
entanglement and corresponds to the amount by which strong subadditivity of von
Neumann entropy fails to be saturated. Our result therefore sheds light on the
structure of states that almost satisfy strong subadditivity with equality. The
proof is based on two recent results from quantum information theory: the
operational interpretation of the quantum mutual information as the optimal
rate for state redistribution and the interpretation of the regularised
relative entropy of entanglement as an error exponent in hypothesis testing.
The distance to the set of separable states is measured by the one-way LOCC
norm, an operationally-motivated norm giving the optimal probability of
distinguishing two bipartite quantum states, each shared by two parties, using
any protocol formed by local quantum operations and one-directional classical
communication between the parties. A similar result for the Frobenius or
Euclidean norm follows immediately. The result has two applications in
complexity theory. The first is a quasipolynomial-time algorithm solving the
weak membership problem for the set of separable states in one-way LOCC or
Euclidean norm. The second concerns quantum Merlin-Arthur games. Here we show
that multiple provers are not more powerful than a single prover when the
verifier is restricted to one-way LOCC operations thereby providing a new
characterisation of the complexity class QMA.Comment: 24 pages, 1 figure, 1 table. Due to an error in the published
version, claims have been weakened from the LOCC norm to the one-way LOCC
nor
Thermography and thermoregulation of the face
BACKGROUND: Although clinical diagnosis of thermoregulation is gaining in importance there is no consistent evidence on the value of thermography of the facial region. In particular there are no reference values established with standardised methods. METHODS: Skin temperatures were measured in the facial area at 32 fixed measuring sites in 26 health subjects (7–72 years) with the aid of a contact thermograph (Eidatherm). A total of 6 measurements were performed separately for the two sides of the face at intervals of equal lengths (4 hours) over a period of 24 hours. Thermoregulation was triggered by application of a cold stimulus in the region of the ipsilateral ear lobe. RESULTS: Comparison of the sides revealed significant asymmetry of face temperature. The left side of the face showed a temperature that was on the average 0.1°C lower than on the right. No increase in temperature was found following application of the cold stimulus. However, a significant circadian rhythm with mean temperature differences of 0.7°C was observed. CONCLUSION: The results obtained should be seen as an initial basis for compiling an exact thermoprofile of the surface temperature of the facial region that takes into account the circadian rhythm, thus closing gaps in studies on physiological changes in the temperature of the skin of the face
9p21 loss confers a cold tumor immune microenvironment and primary resistance to immune checkpoint therapy
Immune checkpoint therapy (ICT) provides substantial clinical benefits to cancer patients, but a large proportion of cancers do not respond to ICT. To date, the genomic underpinnings of primary resistance to ICT remain elusive. Here, we performed immunogenomic analysis of data from TCGA and clinical trials of anti-PD-1/PD-L1 therapy, with a particular focus on homozygous deletion of 9p21.3 (9p21 loss), one of the most frequent genomic defects occurring in ~13% of all cancers. We demonstrate that 9p21 loss confers "cold" tumor-immune phenotypes, characterized by reduced abundance of tumor-infiltrating leukocytes (TILs), particularly, T/B/NK cells, altered spatial TILs patterns, diminished immune cell trafficking/activation, decreased rate of PD-L1 positivity, along with activation of immunosuppressive signaling. Notably, patients with 9p21 loss exhibited significantly lower response rates to ICT and worse outcomes, which were corroborated in eight ICT trials of >1,000 patients. Further, 9p21 loss synergizes with PD-L1/TMB for patient stratification. A "response score" was derived by incorporating 9p21 loss, PD-L1 expression and TMB levels in pre-treatment tumors, which outperforms PD-L1, TMB, and their combination in identifying patients with high likelihood of achieving sustained response from otherwise non-responders. Moreover, we describe potential druggable targets in 9p21-loss tumors, which could be exploited to design rational therapeutic interventions
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