IFN-gamma-mediated suppression of coronavirus replication in glial-committed progenitor cells.

The neurotropic JHM strain of mouse hepatitis virus (JHMV) replicates primarily within glial cells following intracranial inoculation of susceptible mice, with relative sparing of neurons. This study demonstrates that glial cells derived from neural progenitor cells are susceptible to JHMV infection and that treatment of infected cells with IFN-gamma inhibits viral replication in a dose-dependent manner. Although type I IFN production is muted in JHMV-infected glial cultures, IFN-beta is produced following IFN-gamma-treatment of JHMV-infected cells. Also, direct treatment of infected glial cultures with recombinant mouse IFN-alpha or IFN-beta inhibits viral replication. IFN-gamma-mediated control of JHMV replication is dampened in glial cultures derived from the neural progenitor cells of type I receptor knock-out mice. These data indicate that JHMV is capable of infecting glial cells generated from neural progenitor cells and that IFN-gamma-mediated control of viral replication is dependent, in part, on type I IFN secretion

Enemy at the Gate: Threats to Information Security

A firm can build more effective security strategies by identifying and ranking the severity of potential threats to its IS efforts

Editorial

Editorial for Volume 2023, Issue

From the Editors

Welcome to the inaugural issue of the Journal of Cybersecurity Education, Research and Practice (JCERP)

Information Security Governance for the Non-Security Business Executive

Information security is a critical aspect of information systems usage in current organizations. Often relegated to the IT staff, it is in fact the responsibility of senior management to assure the secure use and operation of information assets. Most managers recognize that governance is the responsibility of executive management. The primary objective of governance can be achieved when the members of an organization know what to do, how it should be done, as well as who should do it. The focus on governance has expanded to include information systems and information security. This article offers value to the executive by first defining governance as it is applied to information security and exploring three specific governance-related topics. The first of these examines how governance can be applied the critical aspect of planning both for normal and contingency operations. The next topic describes the need for measurement programs and how such metrics can be developed for information security assessment and continuous improvement. Finally, aspects of effective communication among and between general and information security managers is presented

A Draft Model Curriculum for Programs of Study in Information Security and Assurance

With the dramatic increase in threats to information security, there is a clear need for a corresponding increase in the number of information security professional. With a lack of formal curriculum models, many academic institutions are unprepared to implement the courses and laboratories needed to prepare this special class of information technologist. This paper provides an overview of lessons learned in the implementation of both individual courses and a degree concentration in information security. It refers to a more comprehensive document, available on the Web, which includes the methodology used in developing the curriculum, individual course syllabi for recommended components, and laboratory development and implementation recommendations

Improving Information Security Through Policy Implementation

Information security policy is essential to the success of any information security program because it is the primary process used by organizations to influence the performance of personnel in ways that enhance the information security of the organization’s information assets. Whereas computer security can be thought of as the processes and techniques of securing IT hardware, software and data (including networks), information security is a broader concept. The processes of information security are concerned with the protection of the confidentiality, integrity and availability of information within systems comprising hardware, software, networks, data, procedures and personnel. As organizations change through evolution of practices and hiring of new personnel for growth or replacement policy emerges as the mechanism whereby an organization defines what is to be secured and establishes what to secure, why it needs to be secured and perhaps how to achieve the desired levels of security.. Without sound policy as a foundation an organization is less likely to be successful in its mission to protect information assets