1,680 research outputs found
Pseudomonas aeruginosa induces p38MAP kinase-dependent IL-6 and CXCL8 release from bronchial epithelial cells via a Syk kinase pathway
Pseudomonas aeruginosa (Pa) infection is a major cause of airway inflammation in immunocompromised and cystic fibrosis (CF) patients. Mitogen-activated protein (MAP) and tyrosine kinases are integral to inflammatory responses and are therefore potential targets for novel anti-inflammatory therapies. We have determined the involvement of specific kinases in Pa-induced inflammation. The effects of kinase inhibitors against p38MAPK, MEK 1/2, JNK 1/2, Syk or c-Src, a combination of a p38MAPK with Syk inhibitor, or a novel narrow spectrum kinase inhibitor (NSKI), were evaluated against the release of the proinflammatory cytokine/chemokine, IL-6 and CXCL8 from BEAS-2B and CFBE41o- epithelial cells by Pa. Effects of a Syk inhibitor against phosphorylation of the MAPKs were also evaluated. IL-6 and CXCL8 release by Pa were significantly inhibited by p38MAPK and Syk inhibitors (p<0.05). Phosphorylation of HSP27, but not ERK or JNK, was significantly inhibited by Syk kinase inhibition. A combination of p38MAPK and Syk inhibitors showed synergy against IL-6 and CXCL8 induction and an NSKI completely inhibited IL-6 and CXCL8 at low concentrations. Pa-induced inflammation is dependent on p38MAPK primarily, and Syk partially, which is upstream of p38MAPK. The NSKI suggests that inhibiting specific combinations of kinases is a potent potential therapy for Pa-induced inflammation
Efficient routing of single photons by one atom and a microtoroidal cavity
Single photons from a coherent input are efficiently redirected to a separate
output by way of a fiber-coupled microtoroidal cavity interacting with
individual Cesium atoms. By operating in an overcoupled regime for the
input-output to a tapered fiber, our system functions as a quantum router with
high efficiency for photon sorting. Single photons are reflected and excess
photons transmitted, as confirmed by observations of photon antibunching
(bunching) for the reflected (transmitted) light. Our photon router is robust
against large variations of atomic position and input power, with the observed
photon antibunching persisting for intracavity photon number 0.03 \lesssim n
\lesssim 0.7
Resolved 200 mu m images of nearby galaxies - evidence for an extended distribution of cold dust
The Origin of the Dust Arch in the Halo of NGC 4631: An Expanding Superbubble?
We study the nature and the origin of the dust arch in the halo of the
edge-on galaxy NGC 4631 detected by Neininger & Dumke (1999). We present CO
observations made using the new On-The-Fly mapping mode with the FCRAO 14m
telescope, and find no evidence for CO emission associated with the dust arch.
Our examination of previously published HI data shows that if previous
assumptions about the dust temperature and gas/dust ratio are correct, then
there must be molecular gas associated with the arch, below our detection
threshold. If this is true, then the molecular mass associated with the dust
arch is between 1.5 x 10^8 M(sun)and 9.7 x 10^8 M(sun), and likely towards the
low end of the range. A consequence of this is that the maximum allowed value
for the CO-to-H_2 conversion factor is 6.5 times the Galactic value, but most
likely closer to the Galactic value. The kinematics of the HI apparently
associated with the dust arch reveal that the gas here is not part of an
expanding shell or outflow, but is instead two separate features (a tidal arm
and a plume of HI sticking out into the halo) which are seen projected together
and appear as a shell. Thus there is no connection between the dust "arch" and
the hot X-ray emitting gas that appears to surround the galaxy Wang et al.
(2001).Comment: 14 pages, including 4 figures. Accepted by A.J. for March 200
Resolved 200 mu m images of nearby galaxies - evidence for an extended distribution of cold dust
Economic Impact of Withdrawing Specific Agricultural Pesticides in the Lower Rio Grande Valley
The Air, Pesticides, and Toxics Division of the Environmental Protection Agency (EPA) has encouraged all states to develop a plan to manage the use of pesticides to prevent application that would result in unreasonable risks to human health and the environment from contamination of ground water. In February, 1988, EPA proposed a strategy where by they would regulate certain pesticides by prohibiting their use in areas vulnerable to leaching unless a state develops and implements a management plan acceptable to EPA. However, banning the use of a pesticide in a region is the worst case scenario available to the TWC for managing water quality.
The Texas Water Commission (TWC) assessed the State for areas vulnerable to leaching and found the Lower Rio Grande Valley (LRGV) to be a highly vulnerable area. This study examines three pesticides (atrazine, dicrotophos, and aldicarb) currently used in the LRGV that were identified by the TWC as potential contaminants of ground water. Alternative methods of controlling pests in this region were identified, and the economic impacts of withdrawing one or all three of these pesticides from the study area were estimated.
Regional impacts on gross receipts (sales), variable costs, and net returns were determined. If atrazine use were banned in the LRGV, corn and sorghum sales would decrease by approximately 2 million dollars, leaving farmers in the region with a 600,000 for the region as a whole. Banning aldicarb use in the study area would reduce citrus sales by almost 200,000, and reduce farmer net income by over $3 million annually
A Phase I/IIa Safety and Efficacy Study of Nebulized Liposome-mediated Gene Therapy for Cystic Fibrosis Supports a Multidose Trial
Winter barley : a new factor in Missouri agriculture
Cover title.Includes bibliographical references
- …