Systemic inflammation: Cancer's long-distance reach to maximize metastasis

While major improvements have been made in targeting primary tumor growth, metastasis and combating cancer spread remain an enigma. We recently identified a systemic inflammatory cascade involving IL17-producing γδ T cells and neutrophils that advance breast cancer metastasis. These data provide insights into how immune cells promote cancer spread

Revving up dendritic cells while braking PD-L1 to jump-start the cancer-immunity cycle motor

Although it is successful for some, most melanoma patients are refractory to T cell checkpoint inhibition. In this issue of Immunity, Merad and colleagues (2016) describe a dendritic-cell-based strategy to heighten the efficacy of therapeutic anti-PD-L1 and BRAF inhibitors in mouse melanoma models

Simulating Growth and Development of Tomato Crop

Crop models are powerful tools to test hypotheses, synthesize and convey knowledge, describe and understand complex systems and compare different scenarios. Models may be used for prediction and planning of production, in decision support systems and control of the greenhouse climate, water supply and nutrient supply. The mechanistic simulation of tomato crop growth and development is described in this paper. The main processes determining yield, growth, development and water and nutrient uptake of a tomato crop are discussed in relation to growth conditions and crop management. Organ initiation is simulated as a function of temperature. Simulation of leaf area expansion is also based on temperature, unless a maximum specific leaf area is reached. Leaf area is an important determinant for the light interception of the canopy. Radiation shows exponential extinction with depth in the canopy. For leaf photosynthesis several models are available. Transpiration is calculated according to the Penman-Monteith approach. Net assimilate production is calculated as the difference between canopy gross photosynthesis and maintenance respiration. The net assimilate production is used for growth of the different plant organs and growth respiration. Partitioning of assimilates among plant organs is simulated based on the relative sink strengths of the organs. The simulation of plant-nutrient relationships starts with the calculation of the demanded concentrations of different macronutrients for each plant organ with the demand depending on the ontogenetic stage of the organ. Subsequently, the demanded nutrient uptake is calculated from these demanded concentrations and dry weight of the organs. When there is no limitation in the availability at the root surface, the actual uptake will equal the demanded uptake. When the root system cannot fulfil the demand, uptake is less, plant nutrient concentration drops and crop production might be reduced. It is concluded that mechanistic crop models accurately simulate yield, growth, development and water and nutrient relations of greenhouse grown tomato in different climate zone

Gait and electromyographic analysis of patients recovering after limb-saving surgery

Contains fulltext : 123683.pdf (publisher's version ) (Closed access

XT: a bundle of program transformation tools : system description

{sc xt bundles existing and newly developed program transformation libraries and tools into an open framework that supports component-based development of program transformations. We discuss the roles of {sc xt's constituents in the development process of program transformation tools, as well as some experiences with building program transformation systems with {sc xt. <pr

Numerical and asymptotic solutions of generalised Burgers’ equation

The generalised Burgers’ equation has been subject to a considerable amount of research on how the equation should behave according to asymptotic analysis, however there has been limited research verifying the asymptotic analysis. In order to verify the asymptotic analysis, this paper aims to run long time and detailed numerical simulations of Burgers’ equation by employing suitable rescalings of Burgers’ equation. It is hoped that this technique will make it possible to notice subtle changes in the shock structure which would otherwise be impossible to observe. The main aim of this paper is to validate the numerical methods used in order to allow further research into shock evolution where further relaxation effects will be included

Low multiplicity of infection in vivo results in purifying selection against baculovirus deletion mutants

The in vivo fate of Autographa californica multiple nucleopolyhedrovirus deletion mutants originating from serial passage in cell culture was investigated by passaging a population enriched in these mutants in insect larvae. The infectivity of polyhedra and occlusion-derived virion content per polyhedron were restored within two passages in vivo. The frequency of occurrence of deletion mutants was determined by real-time PCR. The frequency of the non-homologous region origin (non-HR ori) of DNA replication was reduced to wild-type levels within two passages. The frequency of the polyhedrin gene did not increase and remained below wild-type levels. A low m.o.i. during the initial infection in insect larvae, causing strong purifying selection for autonomously replicating viruses, could explain these observations. The same virus population used in vivo was also passaged once at a different m.o.i. in cell culture. A similar effect (i.e. lower non-HR ori frequency) was observed at low m.o.i. only, indicating that m.o.i. was the key selective conditio

Enhancement of superconductivity near the ferromagnetic quantum critical point in UCoGe

We report a high-pressure single crystal study of the superconducting ferromagnet UCoGe. Ac-susceptibility and resistivity measurements under pressures up to 2.2 GPa show ferromagnetism is smoothly depressed and vanishes at a critical pressure $p_c = 1.4$ GPa. Near the ferromagnetic critical point superconductivity is enhanced. Upper-critical field measurements under pressure show $B_{c2}(0)$ attains remarkably large values, which provides solid evidence for spin-triplet superconductivity over the whole pressure range. The obtained $p-T$ phase diagram reveals superconductivity is closely connected to a ferromagnetic quantum critical point hidden under the superconducting `dome'.Comment: 4 pages, 3 figures; accepted for publication in PR

Might EPR particles communicate through a wormhole?

We consider the two-particle wave function of an Einstein-Podolsky-Rosen system, given by a two dimensional relativistic scalar field model. The Bohm-de Broglie interpretation is applied and the quantum potential is viewed as modifying the Minkowski geometry. In this way an effective metric, which is analogous to a black hole metric in some limited region, is obtained in one case and a particular metric with singularities appears in the other case, opening the possibility, following Holland, of interpreting the EPR correlations as being originated by an effective wormhole geometry, through which the physical signals can propagate.Comment: Corrected version, to appears in EP