Gravity substitute workbench /Skylab experiment-M507/ Final report

Design and development of gravity substitute workbench using electrostatic and aerodynamic principle

The association of microstructural connectivity in the brain and auditory modulation of representational momentum

Perceived displacement from an object’s forward trajectory results in a representational momentum (RM) effect. In a behavioural task, participants watched a video of an actor reaching for/withdrawing from an object after hearing ‘I’ll take it’ or ‘I’ll leave it’, which was either congruent or incongruent with the subsequent action witnessed. The knowledge of other people’s intentions through auditory cues and then the predictions of their actions have been found to create an effect on the strength of RM experienced. The degree to which this auditory information affects the RM effect differs for each individual. This variation could, at least partially, be due to the connectivity between parts of the brain which process auditory information, superior temporal sulcus (STS), and parts processing moving visual stimuli (area MT). Fractional anisotropy (FA) and tract-based spatial statistics (TBSS) analysis of diffusion tensor imaging (DTI) data was used to measure the microstructural connectivity of the areas of interest, which was then correlated with the RM data collected from the behavioural task. Results revealed no significant correlation between auditory modulation of RM effect and brain microstructural connectivity. However results were in line with previous research such as that by Kerzel (2005) and Hudson, Nicholson, Ellis and Bach (2015, submitted) by results being in the anticipated direction and some were approaching significance. Results from this study are integral to our understanding of people’s social perception and can help aid therapies for those with neurological and psychiatric disorders

AIR: A Light-Weight Yet High-Performance Dataflow Engine based on Asynchronous Iterative Routing

Distributed Stream Processing Systems (DSPSs) are among the currently most emerging topics in data management, with applications ranging from real-time event monitoring to processing complex dataflow programs and big data analytics. The major market players in this domain are clearly represented by Apache Spark and Flink, which provide a variety of frontend APIs for SQL, statistical inference, machine learning, stream processing, and many others. Yet rather few details are reported on the integration of these engines into the underlying High-Performance Computing (HPC) infrastructure and the communication protocols they use. Spark and Flink, for example, are implemented in Java and still rely on a dedicated master node for managing their control flow among the worker nodes in a compute cluster. In this paper, we describe the architecture of our AIR engine, which is designed from scratch in C++ using the Message Passing Interface (MPI), pthreads for multithreading, and is directly deployed on top of a common HPC workload manager such as SLURM. AIR implements a light-weight, dynamic sharding protocol (referred to as "Asynchronous Iterative Routing"), which facilitates a direct and asynchronous communication among all client nodes and thereby completely avoids the overhead induced by the control flow with a master node that may otherwise form a performance bottleneck. Our experiments over a variety of benchmark settings confirm that AIR outperforms Spark and Flink in terms of latency and throughput by a factor of up to 15; moreover, we demonstrate that AIR scales out much better than existing DSPSs to clusters consisting of up to 8 nodes and 224 cores.Comment: 16 pages, 6 figures, 15 plot

Endocytosis Occurs Independently Of Annexin-Vi In Human A431 Cells

Annexin VI is one of a family of calcium-dependent phospholipid-binding proteins. Although the function of this protein is not known, various physiological roles have been proposed, including a role in the budding of clathrin-coated pits (Lin et al., 1992. Cell. 70:283-291.). In this study we have investigated a possible endocytotic role for annexin VI in intact cells, using the human squamous carcinoma cell line A431, and report that these cells do not express endogenous annexin VI, as judged by Western and Northern blotting and PCR/Southern blotting. To examine whether endocytosis might in some way be either facilitated or inhibited by the presence of annexin VI, a series of A431 clones were isolated in which annexin VI expression was achieved by stable transfection. These cells expressed annexin VI at similar levels to other human cell types. Using assays for endocytosis and recycling of the transferrin receptor, we report that each of these cellular processes occurs with identical kinetics in both transfected and wild-type A431 cells. In addition, purified annexin VI failed to support the scission of coated pits in permeabilized A431 cells. We conclude that annexin VI is not an essential component of the endocytic pathway, and that in A431 cells, annexin VI fails to exert any influence on internalization and recycling of the transferrin receptor

About the Algebraic Solutions of Smallest Enclosing Cylinders Problems

Given n points in Euclidean space E^d, we propose an algebraic algorithm to compute the best fitting (d-1)-cylinder. This algorithm computes the unknown direction of the axis of the cylinder. The location of the axis and the radius of the cylinder are deduced analytically from this direction. Special attention is paid to the case d=3 when n=4 and n=5. For the former, the minimal radius enclosing cylinder is computed algebrically from constrained minimization of a quartic form of the unknown direction of the axis. For the latter, an analytical condition of existence of the circumscribed cylinder is given, and the algorithm reduces to find the zeroes of an one unknown polynomial of degree at most 6. In both cases, the other parameters of the cylinder are deduced analytically. The minimal radius enclosing cylinder is computed analytically for the regular tetrahedron and for a trigonal bipyramids family with a symmetry axis of order 3.Comment: 13 pages, 0 figure; revised version submitted to publication (previous version is a copy of the original one of 2010

Comparative Responsiveness of Pain Measures in Cancer Patients

Brief measures to assess and monitor pain in cancer patients are available, but few head-to-head psychometric comparisons of different measures have been reported. Baseline and 3-month data were analyzed from 274 patients enrolled in the Indiana Cancer Pain and Depression (INCPAD) trial. Participants completed the Brief Pain Inventory (BPI), the PEG (a 3-item abbreviated version of the BPI), the short form (SF)-36 pain scale, and a pain global rating of change measure. The global rating was used as the criterion for standardized response mean and receiver operating characteristic curve analyses. To assess responsiveness to the trial intervention, we evaluated standardized effect size statistics stratified by trial arm. All measures were responsive to global improvement, discriminated between participants with and without improvement, and detected a significant intervention treatment effect. Short and longer measures were similarly responsive. Also, composite measures that combined pain severity and interference into a single score (BPI total, PEG, SF-36 pain) performed comparably to separate measures of each domain (BPI severity and BPI interference)

Characterising the Fermentation Capabilities of Gut Microbial Populations from Different Breeds of Cattle and Sheep Grazing Heathland

Previous studies have demonstrated differences in the diet composition of sheep and cattle when grazing heather moorland, and such differences may in turn lead to differences in rumen fermentation characteristics and associated adaptation to diet. To investigate this further an in vitro gas production experiment was conducted using inocula from different breeds of cattle and sheep grazing heathland