286 research outputs found

    Blockchain-Enabled Provenance Tracking for Sustainable Material Reuse in Construction Supply Chains

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    The growing complexity of construction supply chains and the significant impact of the construction industry on the environment demand an understanding of how to reuse and repurpose materials. In response to this critical challenge, research gaps that are significant in promoting material circularity are described. Despite its potential, the use of blockchain technology in construction faces challenges in verifiability, scalability, privacy, and interoperability. We propose a novel multilayer blockchain framework to enhance provenance tracking and data retrieval to enable a reliable audit trail. The framework utilises a privacy-centric solution that combines decentralised and centralised storage, security, and privacy. Furthermore, the framework implements access control to strengthen security and privacy, fostering transparency and information sharing among the stakeholders. These contributions collectively lead to trusted material circularity in a built environment. The implementation framework aims to create a prototype for blockchain applications in construction supply chains

    Beyond the homunculus: Visual responses of primary somatosensory cortex (S1) neurons to virtual touch of a virtual

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    Following a brief period of brushing a monkey arm with a real brush, synchronized with the vision of an arm avatar being brushed virtually, neurons in the primary somatosensory and motor cortices began to fire in response to the virtual brushing alone, suggesting that cortical representation of the body can be reshaped, in a matter of minutes, to incorporate even virtual limbs

    One-session treatment for specific phobias: barriers, facilitators and acceptability as perceived by children & young people, parents, and clinicians

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    Between 2015 and 2020 the Alleviating Specific Phobias Experienced by Children Trial (ASPECT) was conducted in the UK to examine the non-inferiority of One-Session Treatment in comparison to Cognitive Behavioural Therapy based interventions for children and young people with specific phobias. A nested qualitative evaluation was conducted as part of this trial to examine the acceptability of One-Session Treatment. Qualitative interviews were conducted with children and young people taking part in the trial, their parents/guardians, and clinicians delivering the intervention, about their experiences and the acceptability of One Session Treatment. Interviews were digitally recorded and transcribed verbatim. Analysis followed a qualitative framework approach, a widely used method of analysing primary qualitative data pertaining to healthcare practices with policy relevance. Stakeholder groups found One Session Treatment to be an acceptable intervention and barriers and facilitators for its implementation into services were also identified. Potential barriers included challenges to patient flow and treatment scepticism, whilst facilitators included adopting a child-centred approach, child readiness and suitability, opportunity for increased momentum, parental support and involvement, and proximal and distal gains. For One Session Treatment’s successful implementation into services, consideration of these barriers is needed and suitability guidance for its use in this population should be developed. Further research exploring children and young people’s experiences of receiving Cognitive Behavioural Therapy and its acceptability in comparison to One Session Treatment would be welcomed

    Development of specific PCR assays for the detection of Cryptocaryon irritans

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    Cryptocaryon irritans is one of the most important protozoan pathogens of marine fish, causing the “white spot” disease and posing a significant problem to marine aquaculture. In the present study, a C. irritans-specific reverse primer (S15) was designed based on the published sequence of the second internal transcribed spacer (ITS-2) of ribosomal DNA (rDNA) of C. irritans and used together with the conserved forward primer P1 to develop a specific polymerase chain reaction (PCR) assay for direct, rapid, and specific detection of C. irritans. The specificity of these primers was tested with both closely and distantly related ciliates (Pseudokeroronpsis rubra, Pseudokeroronpsis carnae, Euplotes sp. 1, Ichthyophthirius multifiliis, Pseudourostyla cristata, and Paramecium caudaium), and only C. irritans was detected and no product was amplified from any other ciliates examined in this study using the specific primer set P1-S15. The specific PCR assay was able to detect as low as 45 pg of C. irritans DNA and a nested PCR assay using two primer sets (P1/NC2, P1/S15) increased the sensitivity, allowing the detection of a single C. irritans. The species-specific PCR assays should provide useful tools for the diagnosis, prevention, and molecular epidemiological investigations of C. irritans infection in marine fish
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