Macroscopically distinct quantum superposition states as a bosonic code for amplitude damping

We show how macroscopically distinct quantum superposition states (Schroedinger cat states) may be used as logical qubit encodings for the correction of spontaneous emission errors. Spontaneous emission causes a bit flip error which is easily corrected by a standard error correction circuit. The method works arbitrarily well as the distance between the amplitudes of the superposed coherent states increases.Comment: 4 pages, 2 postscript figures, LaTeX2e, RevTeX, minor changes, 1 reference adde

E4 ligase–specific ubiquitination hubs coordinate DNA double-strand-break repair and apoptosis

Multiple protein ubiquitination events at DNA double-strand breaks (DSBs) regulate damage recognition, signaling and repair. It has remained poorly understood how the repair process of DSBs is coordinated with the apoptotic response. Here, we identified the E4 ubiquitin ligase UFD-2 as a mediator of DNA-damage-induced apoptosis in a genetic screen in Caenorhabditis elegans. We found that, after initiation of homologous recombination by RAD-51, UFD-2 forms foci that contain substrate-processivity factors including the ubiquitin-selective segregase CDC-48 (p97), the deubiquitination enzyme ATX-3 (Ataxin-3) and the proteasome. In the absence of UFD-2, RAD-51 foci persist, and DNA damage-induced apoptosis is prevented. In contrast, UFD-2 foci are retained until recombination intermediates are removed by the Holliday-junction-processing enzymes GEN-1, MUS-81 or XPF-1. Formation of UFD-2 foci also requires proapoptotic CEP-1 (p53) signaling. Our findings establish a central role of UFD-2 in the coordination between the DNA-repair process and the apoptotic response

Anomaly detection search for new resonances decaying into a Higgs boson and a generic new particle X in hadronic final states using √s = 13 TeV pp collisions with the ATLAS detector

A search is presented for a heavy resonance Y decaying into a Standard Model Higgs boson H and a new particle X in a fully hadronic final state. The full Large Hadron Collider run 2 dataset of proton-proton collisions at √ s = 13     TeV collected by the ATLAS detector from 2015 to 2018 is used and corresponds to an integrated luminosity of 139     fb − 1 . The search targets the high Y -mass region, where the H and X have a significant Lorentz boost in the laboratory frame. A novel application of anomaly detection is used to define a general signal region, where events are selected solely because of their incompatibility with a learned background-only model. It is constructed using a jet-level tagger for signal-model-independent selection of the boosted X particle, representing the first application of fully unsupervised machine learning to an ATLAS analysis. Two additional signal regions are implemented to target a benchmark X decay into two quarks, covering topologies where the X is reconstructed as either a single large-radius jet or two small-radius jets. The analysis selects Higgs boson decays into b ¯ b , and a dedicated neural-network-based tagger provides sensitivity to the boosted heavy-flavor topology. No significant excess of data over the expected background is observed, and the results are presented as upper limits on the production cross section σ ( p p → Y → X H → q ¯ q b ¯ b ) for signals with m Y between 1.5 and 6 TeV and m X between 65 and 3000 GeV

Author Correction: Tissue patrol by resident memory CD8+ T cells in human skin (Nature Immunology, (2019), 20, 6, (756-764), 10.1038/s41590-019-0404-3)

In the version of this article initially published, the molecular-weight cutoff of the filtering unit was incorrectly given as 10,000 kDa; the correct value is 10 kDa. The incorrect value was given in Methods section “Generation of fluorescently labeled nanobodies,” in the sentences beginning “Purity of recombinant nanobody was assessed by SDS–PAGE ...” and “Subsequently, the unbound fraction was added ....” In the same section, the buffer composition for the hepta-mutant sortase incorrectly included 10 mM CaCl 2. The correct text is “To this end, purified GGGC–AF594 (80 μM) was incubated with purified nanobody–LPETGG-6×His (5 μM) and penta-mutant (5 M) or hepta-mutant (7 M) sortase (0.8 μM) for 2 h at 4 °C in 50 mM Tris pH 8 and 150 mM NaCl, and in the case of the penta-mutant, 10 mM CaCl 2 was added (sortase was produced in house according to a previously described protocol using sonification instead of French press 40). The errors have been corrected in the HTML and PDF versions of the article

Tissue patrol by resident memory CD8+ T cells in human skin

Emerging data show that tissue-resident memory T (TRM) cells play an important protective role at murine and human barrier sites. TRM cells in the epidermis of mouse skin patrol their surroundings and rapidly respond when antigens are encountered. However, whether a similar migratory behavior is performed by human TRM cells is unclear, as technology to longitudinally follow them in situ has been lacking. To address this issue, we developed an ex vivo culture system to label and track T cells in fresh skin samples. We validated this system by comparing in vivo and ex vivo properties of murine TRM cells. Using nanobody labeling, we subsequently demonstrated in human ex vivo skin that CD8+ TRM cells migrated through the papillary dermis and the epidermis, below sessile Langerhans cells. Collectively, this work allows the dynamic study of resident immune cells in human skin and provides evidence of tissue patrol by human CD8+ TRM cells