F. M. Brouwer and S. van Berkum, CAP and environment in the European Union, Lei-Dlo, Wageningen Pers, 1996

Merlo Maurizio, Rivkine E. N. F. M. Brouwer and S. van Berkum, CAP and environment in the European Union, Lei-Dlo, Wageningen Pers, 1996. In: Cahiers d'Economie et sociologie rurales, N°42-43, 1er et 2e trimestres 1997. économie du développement. Education ; pauvreté ; commerce international. pp. 218-219

Niek Koning, The failure of agrarian capitalism, agrarian politics in the United Kingdom, Germany, the Netherlands and the USA, 1846-1919. London and New York, Routledge, 1964

Thompson Michael, Rivkine E. N. Niek Koning, The failure of agrarian capitalism, agrarian politics in the United Kingdom, Germany, the Netherlands and the USA, 1846-1919. London and New York, Routledge, 1964. In: Cahiers d'Economie et sociologie rurales, N°44, 3e trimestre 1997. pp. 143-146

La valeur d'usage à des fins de loisir des espaces protégés en Espagne. Comparaison entre méthode des coûts de déplacement et méthode d'évaluation contingente

Recreational use value of protected areas in Spain. A comparison of the travel cost and contingent valuation method Valuation of environmental goods, such as protected natural areas, allows us to obtain information that could be included in cost-benefit analysis as an aid for public sector decision-taking processes. This article presents an application of the contingent valuation method and of the travel cost method in order to obtain an estimate of the recreational use value of the Parque Natural del Señorio de Bértiz in Navarra (Spain). The empirical analysis is based on a survey delivered to 402 visitors during spring 1995. The individual travel cost method is based on the estimation of a demand function for the number of trips to the place subject to valuation from which we derive an estimate of consumer's surplus. How do we estimate this cost ? It would seem straight-forward that these costs should be the distance travelled to the park and the time invested in this trip and/or the time spent at the recreational area. If most visitors use private means of transport to get to the recreational area we could calculate the travel cost as : the real variable cost (petrol costs) or the total real costs (variable cost + depreciation). The contingent valuation method is based on the construction of an hypothetical market where we ask visitors directly for their willingness to pay for a visit to the park. In order to obtain the recreational use value of the park we use a dichotomous choice question followed by an open-ended one. After the application of both methods, we remark that the results are close to those obtained in other applications found in environmental goods valuation literature and detect certain sensibility of the results we obtain depending on the hypothesis considered.Ce texte présente deux méthodes d'évaluation utilisées pour mesurer la valeur d'usage à des fins de loisir du Parc naturel du Señorio de Bértiz à Navarre (Espagne). L'analyse empirique se base sur une enquête menée auprès de 402 visiteurs au cours du printemps 1995. La méthode des coûts de déplacement individuel consiste dans l'estimation d'une fonction de demande de déplacement vers le lieu qu'on évalue, et dans l'estimation du surplus du consommateur correspondant. On suppose que le nombre de déplacements est principalement une fonction du coût de déplacement, cette hypothèse étant la principale difficulté de la méthode. L'analyse empirique a été réalisée pour trois options de coût par kilomètre parcouru et un coût d'opportunité de la durée de déplacement. La méthode d'évaluation contingente se base sur la construction d'un marché hypothétique, en interrogeant directement les visiteurs sur leur disposition à payer. Pour obtenir la valeur de loisir qu'ils donnent à l'utilisation du parc, on utilise une question dichotomique suivie d'une question ouverte. L'application de ces deux méthodes montre que les résultats sont proches de ceux obtenus dans d'autres comparaisons disponibles dans la littérature et on constate de même une certaine sensibilité des résultats obtenus aux hypothèses adoptées dans le travail.Pérez y Pérez Luis, Barreiro Jesús, Sánchez Mercedes, Azpilicueta Miren, Rivkine E. N. La valeur d'usage à des fins de loisir des espaces protégés en Espagne. Comparaison entre méthode des coûts de déplacement et méthode d'évaluation contingente. In: Cahiers d'Economie et sociologie rurales, N°41, 4e trimestre 1996. Questions d'économie forestière. Services non marchands ; durabilité et rentabilité ; dynamique des forêts tropicales. pp. 39-56

ONCOGRAM: study protocol for the evaluation of therapeutic response and survival of metastatic colorectal cancer patients treated according to the guidelines of a chemosensitivity assay, the Oncogramme®

International audienceAbstract Background Colorectal cancer is a major public concern, being the second deadliest cancer in the world. Whereas survival is high for localized forms, metastatic colorectal cancer has showed poor prognosis, with a 5-year survival barely surpassing 11%. Conventional chemotherapies against this disease proved their efficiency and remain essential in first-line treatment. However, the large number of authorized protocols complexifies treatment decision. In common practice, such decision is made on an empirical basis, by assessing benefits and risks for the patient. In other words, there is currently no efficient means of predicting the efficacy of any chemotherapy protocol for metastatic colorectal cancer. Methods/design The use of a chemosensitivity assay, the Oncogramme®, should help clinicians administer the best chemotherapy regimen to their patients. We hypothesize it would ultimately improve their survival. In this multicentred, prospective trial (ONCOGRAM), eligible patients with metastatic colorectal cancer are randomized to determine whether they will receive an Oncogramme®. For clinicians whose patients benefited from the assay (arm A), results are used as a decision support tool. Patients not undergoing the Oncogramme® procedure are treated according to current practice, without the assistance of the assay (arm B). Primary outcome is 1-year progression-free survival. Secondary outcomes include response rates, as well as 6-month and 1-year survival rates. Discussion This study aims at investigating the clinical utility of the Oncogramme® as a decision support tool for the treatment of patients with metastatic colorectal cancer. If the Oncogramme® positively influenced patient overall survival and/or progression-free survival, it would be of great value for clinicians to implement this assay within the current landscape of personalized medicine tools, which include genomics and biomarker assays. Trial registration ClinicalTrials.gov identifier NCT03133273 . Registered on April 28, 2017

Rare neoplasms

Although interest in pancreatic pathology is very high in the radiological and gastroenterological communities, it is still the case that less is known about pathology of the pancreas than about liver pathology, for example. Diagnosis depends on the structure of the pancreatic lesion, which can be directly visualized on US, CT or MR images. This atlas, which encompasses both the imaging and the pathology of pancreatic neoplasms, will therefore be invaluable in enabling radiologists and sonographers to understand the underlying pathology and in allowing pancreatic pathologists to understand the imaging translation. The emphasis in the atlas is very much on the pathological and imaging appearances, with most of the text concentrated at the beginning of the chapters. A comprehensive overview is provided of typical and atypical presentations and diverse aspects of common and uncommon pancreatic neoplasms, including ductal adenocarcinoma, neuroendocrine neoplasms, intraductal papillary mucinous neoplasms, cystic neoplasms, metastases and lymphoma