Pathological classification of equine recurrent laryngeal neuropathy

Recurrent Laryngeal Neuropathy (RLN) is a highly prevalent and predominantly left‐sided, degenerative disorder of the recurrent laryngeal nerves (RLn) of tall horses, that causes inspiratory stridor at exercise because of intrinsic laryngeal muscle paresis. The associated laryngeal dysfunction and exercise intolerance in athletic horses commonly leads to surgical intervention, retirement or euthanasia with associated financial and welfare implications. Despite speculation, there is a lack of consensus and conflicting evidence supporting the primary classification of RLN, as either a distal (“dying back”) axonopathy or as a primary myelinopathy and as either a (bilateral) mononeuropathy or a polyneuropathy; this uncertainty hinders etiological and pathophysiological research. In this review, we discuss the neuropathological changes and electrophysiological deficits reported in the RLn of affected horses, and the evidence for correct classification of the disorder. In so doing, we summarize and reveal the limitations of much historical research on RLN and propose future directions that might best help identify the etiology and pathophysiology of this enigmatic disorder

Public Health Workforce Shortages Imperil Nation's Health

Examines from a community-based perspective the scope of the shortages in the public health workforce; contributing factors such as inadequate funding, salaries, and benefits; and strategies for training, recruiting, and retaining public health workers

Lifting the Veil on Obscured Accretion: Active Galactic Nuclei Number Counts and Survey Strategies for Imaging Hard X-Ray Missions

Finding and characterizing the population of active galactic nuclei (AGNs) that produces the X-ray background (XRB) is necessary to connect the history of accretion to observations of galaxy evolution at longer wavelengths. The year 2012 will see the deployment of the first hard X-ray imaging telescope which, through deep extragalactic surveys, will be able to measure the AGN population at the energies where the XRB peaks (~20-30 keV). Here, we present predictions of AGN number counts in three hard X-ray bandpasses: 6-10 keV, 10-30 keV, and 30-60 keV. Separate predictions are presented for the number counts of Compton thick AGNs, the most heavily obscured active galaxies. The number counts are calculated for five different models of the XRB that differ in the assumed hard X-ray luminosity function, the evolution of the Compton thick AGNs, and the underlying AGN spectral model. The majority of the hard X-ray number counts will be Compton thin AGNs, but there is a greater than tenfold increase in the Compton thick number counts from the 6-10 keV to the 10-30 keV band. The Compton thick population shows enough variation that a hard X-ray number counts measurement will constrain the models. The computed number counts are used to consider various survey strategies for the NuSTAR mission, assuming a total exposure time of 6.2 Ms. We find that multiple surveys will allow a measurement of Compton thick evolution. The predictions presented here should be useful for all future imaging hard X-ray missions

Massachusetts Health Reform: High Costs and Expanding Expectations May Weaken Employer Support

Examines how, as a result of the state's health reform, improved access to the individual insurance market and increased employer responsibility may reduce employers' motivation and ability to provide coverage. Considers implications

An empirical study on the preferred size of the participant information sheet in research

Background: Informed consent is a requirement for all research. It is not, however, clear how much information is sufficient to make an informed decision about participation in research. Information on an online questionnaire about childhood development was provided through an unfolding electronic participant sheet in three levels of information. \ud Methods: 552 participants, who completed the web-based survey, accessed and spent time reading the participant information sheet (PIS) between July 2008 and November 2009. The information behaviour of the participants was investigated. The first level contained less information than might be found on a standard PIS, the second level corresponded to a standard PIS, and the third contained more information than on a standard PIS. The actual time spent on reading the information provided in three incremental levels and the participants' evaluation of the information were calculated. \ud Results: 77% of the participants chose to access the first level of information, whereas 12% accessed the first two levels, 6% accessed all three levels of information and 23% participated without accessing information. The most accessed levels of information were those that corresponded to the average reading times. \ud Conclusion: The brief information provided in the first level was sufficient for participants to make informed decisions, while a sizeable minority of the participants chose not to access any information at all. This study adds to the debate about how much information is required to make a decision about participation in research and the results may help inform the future development of information sheets by providing data on participants' actual needs when deciding about questionnaire surveys.\u

SUSY-Breaking Parameters from RG Invariants at the LHC

We study Renormalization Group invariant (RGI) quantities in the Minimal Supersymmetric Standard Model and show that they are a powerful and simple instrument for testing high scale models of supersymmetry (SUSY)-breaking. For illustration, we analyze the frameworks of minimal and general gauge mediated (MGM and GGM) SUSY-breaking, with additional arbitrary soft Higgs mass parameters at the messenger scale. We show that if a gaugino and two first generation sfermion soft masses are determined at the LHC, the RGIs lead to MGM sum rules that yield accurate predictions for the other gaugino and first generation soft masses. RGIs can also be used to reconstruct the fundamental MGM parameters (including the messenger scale), calculate the hypercharge D-term, and find relationships among the third generation and Higgs soft masses. We then study the extent to which measurements of the full first generation spectrum at the LHC may distinguish different SUSY-breaking scenarios. In the case of MGM, although most deviations violate the sum rules by more than estimated experimental errors, we find a 1-parameter family of GGM models that satisfy the constraints and produce the same first generation spectrum. The GGM-MGM degeneracy is lifted by differences in the third generation masses and the messenger scales.Comment: (v1) 30 pages; (v2) mislabeling in figs 2 and 3 corrected, version accepted for publication in Phys. Rev.

Using Rheo-Small-Angle Neutron Scattering to Understand How Functionalised Dipeptides Form Gels

We explore the use of rheo-small-angle neutron scattering as a method to collect structural information from neutron scattering simultaneously with rheology to understand how low-molecular-weight hydrogels form and behave under shear. We examine three different gelling hydrogel systems to assess what structures are formed and how these influence the rheology. Furthermore, we probe what is happening to the network during syneresis and why the gels do not recover after an applied strain. All this information is vital when considering gels for applications such as 3D-printing and injection

Determining the Structure of Supersymmetry-Breaking with Renormalization Group Invariants

If collider experiments demonstrate that the Minimal Supersymmetric Standard Model (MSSM) is a good description of nature at the weak scale, the experimental priority will be the precise determination of superpartner masses. These masses are governed by the weak scale values of the soft supersymmetry (SUSY)-breaking parameters, which are in turn highly dependent on the SUSY-breaking scheme present at high scales. It is therefore of great interest to find patterns in the soft parameters that can distinguish different high scale SUSY-breaking structures, identify the scale at which the breaking is communicated to the visible sector, and determine the soft breaking parameters at that scale. In this work, we demonstrate that 1-loop Renormalization Group~(RG) invariant quantities present in the MSSM may be used to answer each of these questions. We apply our method first to generic flavor-blind models of SUSY-breaking, and then examine in detail the subset of these models described by General Gauge Mediation and the constrained MSSM with non-universal Higgs masses. As RG invariance generally does not hold beyond leading-log order, we investigate the magnitude and direction of the 2-loop corrections. We find that with superpartners at the TeV scale, these 2-loop effects are either negligible, or they are of the order of optimistic experimental uncertainties and have definite signs, which allows them to be easily accounted for in the overall uncertainty.Comment: v2 -- references added, version to be published in PRD; 40 page

Reversible Photoreduction as a Trigger for Photoresponsive Gels

We present here a new type of photoresponsive, reversible low molecular weight gel. All previous examples rely on a photoisomerisation, ring-closing or dimerization. We show that photoreduction of a perylene bisimide gelator results in the formation of a stable radical anion. The formation of the radical anion results in a change in the packing of the perylene bisimides in the self-assembled aggregates, leading to a change in fibrous network and an increase in the rheological properties of the gels. An increase in the rheological properties is extremely rare for a photoresponsive gel; normally, irradiation results in a gel-to-sol transition, and the gel falling apart. As the radical anion decays, which takes several hours in air, the original gel properties are restored. This photoreduction can be cycled many times. Finally, we show that the mechanical properties are different between irradiated and nonirradiated sections in a patterned gel

Disk-Loss and Disk Renewal Phases in Classical Be Stars II. Detailed Analysis of Spectropolarimetric Data

In Wisniewski et al. 2010, paper I, we analyzed 15 years of spectroscopic and spectropolarimetric data from the Ritter and Pine Bluff Observatories of 2 Be stars, 60 Cygni and {\pi} Aquarii, when a transition from Be to B star occurred. Here we anaylize the intrinsic polarization, where we observe loop-like structures caused by the rise and fall of the polarization Balmer Jump and continuum V-band polarization being mismatched temporally with polarimetric outbursts. We also see polarization angle deviations from the mean, reported in paper I, which may be indicative of warps in the disk, blobs injected at an inclined orbit, or spiral density waves. We show our ongoing efforts to model time dependent behavior of the disk to constrain the phenomena, using 3D Monte Carlo radiative transfer codes.Comment: 2 pages, 6 figures, IAU Symposium 27