Strange Bodies and Familiar Spaces: W. J. R. Simpson and the threat of disease in Calcutta and the tropical city, 1880 - 1910

This thesis discusses the role of urban sanitation in tropical cities, especially Calcutta. Focusing particularly on the provision of milk, the author argues that hygienic practice, and the culture of nineteenth-century tropical medicine, created more diffuse racial deliniations than usually assumed by historians [abstracted by librarian]

Patch Plate Materials Compatibility Assessment

Lunar dust proved to be a greater problem during the Apollo missions than was originally anticipated. The highly angular, charged dust particles stuck to seals, radiators, and visors; clogged mechanisms; and abraded space suits. As reported by Apollo 12 astronaut Pete Conrad "We must have had more than a hundred hours suited work with the same equipment, and the wear was not as bad on the training suits as it is on these flight suits in just the eight hours we were out.". Dust clinging to surfaces was also transport-ed into habitable spaces leading to lung and eye irritation of the astronauts. The Apollo astronauts were on the Lunar surface less than 24 hours and experienced many dust related problems. With the Artemis program, we are planning longer stays on the surface, with more activities that have the potential to put the astronauts and equipment in contact with greater quantities of Lunar dust. The success of these missions will depend on our understanding of material interactions with Lunar dust and the development of ways to mitigate dust effects in cases where exposure to dust will lead to failure of components, unacceptable loss of power or thermal control, unacceptable loss of visibility, or health issues. Through the Lunar Surface In-novation Initiative (LSII), we are initiating a Patch Plate Materials Compatibility Assessment project. The overall goal of the three year project is to develop passive approaches to mitigate Lunar dust adhesion to surfaces for technologies that are currently at TRL levels 2-3 to bring them to TRL level 5 through ground-based assessment, culminating in a demonstration flight experiment on a Commercial Lunar Payload Services (CLPS) lander in 2022-2023. This paper discusses the detailed technical objectives and approach for this project. References: Gaier, J.R. "The Effects of Lunar Dust on EVA Systems During the Apollo Missions," NASA/TM-2005-213610/REV1, (2005), Apollo 12 Technical Crew Debriefing, December 1, 1969, pp. 10-54

NASA's Core Flight Software - A Reusable Real-Time Framework

No abstract availabl

Computer-assisted detection of pulmonary embolism: evaluation of pulmonary CT angiograms performed in an on-call setting

Item does not contain fulltextPURPOSE: The purpose of the study was to assess the stand-alone performance of computer-assisted detection (CAD) for evaluation of pulmonary CT angiograms (CTPA) performed in an on-call setting. METHODS: In this institutional review board-approved study, we retrospectively included 292 consecutive CTPA performed during night shifts and weekends over a period of 16 months. Original reports were compared with a dedicated CAD system for pulmonary emboli (PE). A reference standard for the presence of PE was established using independent evaluation by two readers and consultation of a third experienced radiologist in discordant cases. RESULTS: Original reports had described 225 negative studies and 67 positive studies for PE. CAD found PE in seven patients originally reported as negative but identified by independent evaluation: emboli were located in segmental (n = 2) and subsegmental arteries (n = 5). The negative predictive value (NPV) of the CAD algorithm was 92% (44/48). On average there were 4.7 false positives (FP) per examination (median 2, range 0-42). In 72% of studies or=10 FP. CONCLUSION: CAD identified small emboli originally missed under clinical conditions and found 93% of the isolated subsegmental emboli. On average there were 4.7 FP per examination.1 april 201

From Rat to Human: Regulation of Renin-Angiotensin System Genes by Sry

The testis determining protein, Sry, has functions outside of testis determination. Multiple Sry loci are found on the Y-chromosome. Proteins from these loci have differential activity on promoters of renin-angiotensin system genes, possibly contributing to elevation of blood pressure. Variation at amino acid 76 accounts for the majority of differential effects by rat proteins Sry1 and Sry3. Human SRY regulated rat promoters in the same manner as rat Sry, elevating Agt, Ren, and Ace promoter activity while downregulating Ace 2. Human SRY significantly regulated human promoters of AGT, REN, ACE2, AT2, and MAS compared to control levels, elevating AGT and REN promoter activity while decreasing ACE2, AT2, and MAS. While the effect of human SRY on individual genes is often modest, we show that many different genes participating in the renin-angiotensin system can be affected by SRY, apparently in coordinated fashion, to produce more Ang II and less Ang-(1–7)

X-ray computed microtomography of late copper age decorated bowls with cross-shaped foots from central Slovenia and the Trieste Karst (North-Eastern Italy): technology and paste characterization.

About 20 Late Copper Age bowls with cross-shaped foots from Deschmann\u2019s pile dwellings (Ljubljansko barje, central Slovenia) and Trieste Karst (North-Eastern Italy) have been investigated using X-ray computed microtomography (microCT) in order to study the vessel-forming technique, to characterise their pastes and to test the hypothesis that some Karst bowls could have been imported from nowadays central Slovenia or even more distant regions. In three selected virtual slices per sample, clay, lithic inclusions and pores have been segmented and quantified. In addition, the area, maximum length and width of each lithic inclusion have been calculated. Then, the microCT-derived results have been statistically analysed by principal component analysis (PCA). The orientation of pores and disjunctions in microCT volumes show that the basins of the bowls were built using mainly the coiling technique, while the base was shaped starting from a central piece, to which a layer of clay was added and then reshaped in order to produce the foots. The Slovenian bowls include both medium/coarse-grained and very fine- or fine-grained vessels mainly tempered with carbonate inclusions. The pastes of the Karst bowls are considerably heterogeneous. One bowl was most likely imported to the Karst but not from central Slovenia as it shows peculiar components, shape and decoration. The other two imported vessels show a very fine-grained paste comparable to the one of several samples from Deschmann\u2019s pile dwellings. Such technological similarity is confirmed by PCA of microCT data and petrographic observations. Our study confirms the existence of strong cultural connections between central Slovenia and the northernmost Adriatic coast during the Late Copper Age