Doença hepática gordurosa não alcoólica e cirurgia bariátrica: uma revisão abrangente

sem informaçãoNonalcoholic fatty liver disease (NAFLD) has been increasingly diagnosed worldwide and is now recognized as a source of public health concern. It comprises a wide spectrum of histological features that range from simple steatosis to severe forms of fibros1353277295sem informaçãosem informaçãosem informaçã

Predictors for weight loss failure following roux-en-y gastric bypass

Weight loss failure is a widely recognized occurrence following Roux-en-Y gastric bypass. This study aims to identify predictors associated with weight loss failure. It is a retrospective cohort which enrolled 187 subjects who underwent RYGB. Comparisons were made between patients' features at baseline and 24 months after surgery. A weight loss failure rate of 11.2% was found. Advanced age and diabetes were statistically associated with failure. The results found were close to previous reports. As weight loss failure represents an important concern, there is the possibility to perform revisional surgeries, which may emphasize the restrictive or malabsorptive characteristics of RYGB, leading to varied results. It is reinforced that weight loss cannot be used as the unique outcome to evaluate the success of surgery.Weight loss failure is a widely recognized occurrence following Roux-en-Y gastric bypass. This study aims to identify predictors associated with weight loss failure. It is a retrospective cohort which enrolled 187 subjects who underwent RYGB. Comparisons514328330sem informaçãosem informaçã

Local freedom in the gravitational field revisited

Maartens {\it et al.}\@ gave a covariant characterization, in a 1+3 formalism based on a perfect fluid's velocity, of the parts of the first derivatives of the curvature tensor in general relativity which are ``locally free'', i.e. not pointwise determined by the fluid energy momentum and its derivative. The full decomposition of independent curvature derivative components given in earlier work on the spinor approach to the equivalence problem enables analogous general results to be stated for any order: the independent matter terms can also be characterized. Explicit relations between the two sets of results are obtained. The 24 Maartens {\it et al.} locally free data are shown to correspond to the $\nabla \Psi$ quantities in the spinor approach, and the fluid terms are similarly related to the remaining 16 independent quantities in the first derivatives of the curvature.Comment: LaTeX. 13 pp. To be submitted to Class. Quant. Gra

Influence of type 2 diabetes mellitus on liver histology among morbidly obese individuals: a cross-sectional study

Nonalcoholic fatty liver disease (NAFLD) has become a public health concern. It encompasses a wide spectrum of histological abnormalities and has close relationships with insulin resistance and type 2 diabetes mellitus (T2DM). This study sought to compare13417983sem informaçãosem informaçã

Modelo de elementos finitos de la columna lumbar

En este trabajo se describe un modelo de Elementos Finitos de la columna lumbar humana. El objetivo buscado es la utilización del mismo como herramienta de investigación aplicada a la cirugía ortopédica de columna lumbar. Para conseguir este objetivo se ha elaborado un modelo no lineal y paramétrico de la columna lumbar completa, el cual puede modificarse con facilidad tanto en su geometría como en sus características mecánicas de modo que puedan reflejarse tanto distintas alteraciones segmentarias como diversas técnicas de fijación. También se expone la contrastación del modelo, realizada a partir de resultados experimentales recogidos de la literatura sobre el tema.Peer Reviewe

Preliminary screening of polycaprolactone-polystyrene electrospun scaffolds for the formation of tumoroids

Triple negative breast cancer (TNBC) subtype is the most aggressive and conventional chemotherapy is the standard treatment since lacks validated targeted therapies. Thus, there is an unmet need for improved in vitro research tools, including scaffolds for the formation of tumoroids. In this preliminary study, the main aim was to assess the tumoroid-forming potential of polycaprolactone (PCL)/polystyrene (PS) scaffolds. Six different polymer solutions, varying PCL/PS ratios, were formulated and PCL/PS scaffolds were manufactured using the electrospinning technique. PCL/PS structures were characterized by SEM imaging. Subsequently, a sterilization assay was performed to evaluate potential alterations derived from this process. Afterwards, TNBC MDA-MB-231 cells were cultured on PCL/PS structures for 10 days. The findings revealed that cells cultured on PCL 100/PS 0, PCL 80/PS 20, and PCL 60/PS 40 matrices exhibited the formation of tumoroids. In conclusion, PCL/PS scaffolds offer a valuable in vitro tool for tumoroid formation.This work was funded by PLEC2021-007523 / AEI / 10.13039/501100011033 and by the European Union – NextGenerationEU. It was also supported by Spanish grant from Instituto de Salud Carlos III and co-funded by European Union ERDF/ESF, “A way to make Europe”/ “Investing in your future”)(PI19/00372). The authors thank the support of Catalan Government (2021SGR01589) and Oncolliga Foundation and RadikalSwim (OncoSwim). The authors thank Research Technical Services from the University of Girona

Epicrania fugax with backward radiation: clinical characteristics of nine new cases

Epicrania fugax (EF) is a novel syndrome, described as a paroxysmal and brief head pain, starting in posterior cranial regions and rapidly spreading forward ipsilateral eye, nose or forehead. Two patients with comparable clinical features stemming from frontal scalp to ipsilateral posterior regions have been recently described and proposed as backward radiation epicrania fugax (BREF). We report a new series of nine BREF and compare their clinical characteristics with 18 forward radiation EF (FREF). Since first description of BREF in February 2010 we have assessed nine patients (four males, five females) with this clinical picture at an outpatient headache office in a Tertiary Hospital. Comparison is established with 18 FREF patients (6 males, 12 females), attended since the publication of first series of EF in March 2008. We found no differences between BREF and FREF, respectively, in age at onset (43.4 ± 13.1 vs. 42.5 ± 17.7 years), female/male ratio (5/4 vs. 12/6), pain intensity (6.9 ± 2.1 vs. 6.8 ± 2.1 in a 0–10 visual analogical scale), duration (7.1 ± 4.9 vs. 5.7 ± 4.3 s) and frequency of episodes per day (7 ± 8.4 vs. 9.9 ± 15.4). Patients in BREF group presented less frequently interictal pain in stemming point (22.2 vs. 55.5%) and accompanying autonomic signs (33.3 vs. 55.5%), but without statistical significance in both the cases. This series reinforces the proposal of EF as a new headache variant or a new headache syndrome. Clinical picture of brief pain paroxysms starting in the anterior scalp and radiating backwards does not fit known headaches or neuralgias and might correspond to a reverse variant of EF, clinical characteristics of which are comparable to FREF