Under the influence of new educational technologies: the theory of electrolytic dissociation

The article describes a computer programs for study of the chemistry section, training calculations and knowledge testРассмотрены компьютерные программы для изучения студентами химии, выполнения ими практических заданий и проверки знани

Environmental Aspects in Teaching Discipline "Life Safety" in the College

Непрерывность получения актуальных знаний и навыков является одним из основных принципов в экологическом образовании. В статье обсуждается актуальность и целесообразность использования в курсе «Безопасность жизнедеятельности» экологического подхода к рассмотрению ряда тем учебного плана дисциплины. Показана взаимосвязь вопросов экологической безопасности и безопасности жизнедеятельности.Continuity in obtaining relevant knowledge and skills is one of the main principles in environmental education. The article discusses the relevance and expediency of using an ecological approach to the consideration of a number of topics in the curriculum of the discipline in the course "Life Safety". The interrelation of questions of ecological safety and life safety is shown

α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site.

Tumors are fibrotic and characterized by abundant, remodeled, and cross-linked collagen that stiffens the extracellular matrix stroma. The stiffened collagenous stroma fosters malignant transformation of the tissue by increasing tumor cell tension to promote focal adhesion formation and potentiate growth factor receptor signaling through kinase. Importantly, collagen cross-linking requires fibronectin (FN). Fibrotic tumors contain abundant FN, and tumor cells frequently up-regulate the FN receptor α5β1 integrin. Using transgenic and xenograft models and tunable two- and three-dimensional substrates, we show that FN-bound α5β1 integrin promotes tension-dependent malignant transformation through engagement of the synergy site that enhances integrin adhesion force. We determined that ligation of the synergy site of FN permits tumor cells to engage a zyxin-stabilized, vinculin-linked scaffold that facilitates nucleation of phosphatidylinositol (3,4,5)-triphosphate at the plasma membrane to enhance phosphoinositide 3-kinase (PI3K)-dependent tumor cell invasion. The data explain why rigid collagen fibrils potentiate PI3K activation to promote malignancy and offer a perspective regarding the consistent up-regulation of α5β1 integrin and FN in many tumors and their correlation with cancer aggression

Плоды свидины белой ( Swida alba ( L.) Opiz) — перспективный источник жирного масла

The paper deals with study of locating, content and composition of fatty oil in Siberian Dogwood’s fruits, pericarp and seed.Статья посвящена изучению локализации, содержания и состава жирного масла в плодах, околоплоднике и семенах свидины белой — Swida alba ( L.) Opiz

Ecological Aspects of Plant Protein Production

В статье рассматривается проблема дефицит пищевого белка и возможные пути ее решения. С экологических позиций проанализированы достоинства и недостатки сырьевой базы животного и растительного белка. Охарактеризованы перспективы производства горохового протеина.There are discussed the problem of nutritional protein deficiency and possible ways to solve it. The advantages and disadvantages of the raw material base of animal and vegetable protein are analyzed from the ecological positions . The prospects for the production of pea protein are characterized

The creation and characterization of the bread wheat line with a centric translocation T2DL.2RL

The development of bread wheat introgressions with alien genetic material from cultural and wild Triticeae species is an effective method for expanding the wheat gene pool necessary for breeding. To date, numerous collections of introgressions as substitutions and chromosome modifications have been obtained; however, the creation and study of wheat with new valuable traits still remain an important line of research. Rye Secale cereale L., whose chromosomes carry genes that control valuable economic and biological characteristics and properties, is widely used to produce new wheat forms. In this study, a wheat-rye translocation obtained by backcrossing the wheat-rye disomic-substitution line 2R(2D)1 with the variety Novosibirskaya 67 was characterized. The chromosomal composition of karyotypes was studied using fluorescent in situ hybridization and C-banding. Two centric translocations, derived from two long arms of chromosomes 2D and 2R, T2DL.2RL, were identified, the remaining 40 wheat chromosomes did not undergo modifications. Meiosis in the lines was stable. Chromosomes T2DL.2RL formed bivalents in all meiocytes, which confirmed their homology. The morphological characteristics of the spike in the T2DL.2RL line and Novosibirskaya 67 did not differ. A comparative analysis of productivity between the T2DL.2RL translocation line and the parental forms, Novosibirskaya 67 and the 2R(2D)1 line, was carried out. The T2DL.2RL line is inferior to Novosibirskaya 67 in all characters with different confidence levels. The productivity characters of the 2R(2D)1 line exceeded or did not differ from those of T2DL.2RL, however, the mass of 1000 grains was significantly lower. The results showed the effect of the T2DL.2RL translocation on the trait “plant height”. This character was significantly lower than that of Novosibirskaya 67 in two vegetation periods. Consequently, the T2DL.2RL translocation reduces plant height and productivity

Dysfunctional LAT2 Amino Acid Transporter Is Associated With Cataract in Mouse and Humans.

Cataract, the loss of ocular lens transparency, accounts for ∼50% of worldwide blindness and has been associated with water and solute transport dysfunction across lens cellular barriers. We show that neutral amino acid antiporter LAT2 (Slc7a8) and uniporter TAT1 (Slc16a10) are expressed on mouse ciliary epithelium and LAT2 also in lens epithelium. Correspondingly, deletion of LAT2 induced a dramatic decrease in lens essential amino acid levels that was modulated by TAT1 defect. Interestingly, the absence of LAT2 led to increased incidence of cataract in mice, in particular in older females, and a synergistic effect was observed with simultaneous lack of TAT1. Screening SLC7A8 in patients diagnosed with congenital or age-related cataract yielded one homozygous single nucleotide deletion segregating in a family with congenital cataract. Expressed in HeLa cells, this LAT2 mutation did not support amino acid uptake. Heterozygous LAT2 variants were also found in patients with cataract some of which showed a reduced transport function when expressed in HeLa cells. Whether heterozygous LAT2 variants may contribute to the pathology of cataract needs to be further investigated. Overall, our results suggest that defects of amino acid transporter LAT2 are implicated in cataract formation, a situation that may be aggravated by TAT1 defects

АНТОШКА И СВЕТЛЯЧОК – НОВЫЕ СОРТА ФАСОЛИ ОВОЩНОЙ СЕЛЕКЦИИ ВНИИССОК

As a result of many years breeding, two varieties of southern bean have been developed. Cultivar «Antoshka» is climbing bean for farm gardening. Cultivar «Svetlyachok» is bunch,forming cultivar. Both varieties are suitable for mechanized cultivation. They are characterized by high content of sugars and ascorbic acid. These cultivars are recommended for freezing.В результате многолетней селекционной работы созданы два спаржевых сорта фасоли овощной: вьющийся сорт Антошка для приусадебного овощеводства и кустовой – Светлячок. Сорта пригодны для механизированных технологий возделывания, с высоким содержанием сахаров и витамина С, рекомендованы для заморозки