Explaining the influence of prior knowledge on POMCP policies

Partially Observable Monte Carlo Planning is a recently proposed online planning algorithm which makes use of Monte Carlo Tree Search to solve Partially Observable Monte Carlo Decision Processes. This solver is very successful because of its capability to scale to large uncertain environments, a very important property for current real-world planning problems. In this work we propose three main contributions related to POMCP usage and interpretability. First, we introduce a new planning problem related to mobile robot collision avoidance in paths with uncertain segment difficulties, and we show how POMCP performance in this context can take advantage of prior knowledge about segment difficulty relationships. This problem has direct real-world applications, such as, safety management in industrial environments where human-robot interaction is a crucial issue. Then, we present an experimental analysis about the relationships between prior knowledge provided to the algorithm and performance improvement, showing that in our case study prior knowledge affects two main properties, namely, the distance between the belief and the real state, and the mutual information between segment difficulty and action taken in the segment. This analysis aims to improve POMCP explainability, following the line of recently proposed eXplainable AI and, in particular, eXplainable planning. Finally, we analyze results on a synthetic case study and show how the proposed measures can improve the understanding about internal planning mechanisms

Phosphene-guided transcranial magnetic stimulation of occipital but not parietal cortex suppresses stimulus visibility.

Transcranial magnetic stimulation (TMS) applied over the occipital lobe approximately 100 ms after the onset of a stimulus decreases its visibility if it appears in the location of the phosphene. Because phosphenes can also be elicited by stimulation of the parietal regions, we asked if the same procedure that is used to reduce visibility of stimuli with occipital TMS will lead to decreased stimulus visibility when TMS is applied to parietal regions. TMS was randomly applied at 0-130 ms after the onset of the stimulus in steps of 10 ms in occipital and parietal regions. Participants responded to the orientation of the line stimulus and rated its visibility. We replicate previous reports of phosphenes from both occipital and parietal TMS. As previously reported, we also observed visual suppression around the classical 100 ms window both in the objective line orientation and subjective visibility responses with occipital TMS. Parietal stimulation, on the other hand, did not consistently reduce stimulus visibility in any time window. http://dx.doi.org/10.1007/s00221-014-3923-z

Effect of juice turbidity on fermentative volatile compounds in white wines

'Chardonnay' (n = 4), 'Pinot gris' (n = 3) and 'Müller-Thurgau' juices (n = 3), each at 6 turbidity levels (15, 45, 86, 141, 215 and 350 NTU) obtained by adding increasing amounts of their own fine juice lees, were fermented using 'Montrachet Red Star' yeast. The main volatile compounds in free form which may have a sensory role were measured using GC-FID, with a DB-WAX column, after fixing onto Isolute ENV+ resin. Changes for around 40 volatile compounds and fermentation parameters are shown. Juice turbidity levels just below 100 NTU are the best compromise for obtaining adequate fruity notes and minimising languishing fermentation and off-flavours in white wine, if correct microbiology management at the winery is guaranteed, whereas slightly higher NTU levels could contribute to a slightly more complex aroma. However, variability due to juice turbidity in the range investigated is lower than variability due to yeast strain observed in a previous experiment. Thus the choice of yeast strain to direct white wine aroma must be overriding as compared to NTU levels.

Oral Feeding Competences of Healthy Preterm Infants: A Review

Background. With increasing sophistication and technology, survival rates hugely improved among preterm infants admitted to the neonatal intensive care unit. Nutrition and feeding remain a challenge and preterm infants are at high risk of encountering oral feeding difficulties. Objective. To determine what facts may impact on oral feeding readiness and competence and which kind of interventions should enhance oral feeding performance in preterm infants. Search Strategy. MEDILINE database was explored and articles relevant to this topic were collected starting from 2009 up to 2011. Main Results. Increasingly robust alertness prior to and during feeding does positively impact the infant's feeding Skills. The review found that oral and non-oral sensorimotor interventions, provided singly or in combination, shortened the transition time to independent oral feeding in preterm infants and that preterm infants who received a combined oral and sensorimotor intervention demonstrated more advanced nutritive sucking, suck-swallow and swallow-respiration coordination than those who received an oral or sensorimotor intervention singly

Reachability computation for hybrid systems with Ariadne

Ariadne is an in-progress open environment to design algorithms for computing with hybrid automata, that relies on a rigorous computable analysis theory to represent geometric objects, in order to achieve provable approximation bounds along the computations. In this paper we discuss the problem of reachability analysis of hybrid automata to decide safety properties. We describe in details the algorithm used in Ariadne to compute over-approximations of reachable sets. Then we show how it works on a simple example. Finally, we discuss the lower-approximation approach to the reachability problem and how to extend Ariadne to support it

Coronary Artery Stenting Affects Wall Shear Stress Topological Skeleton

Despite the important advancements in the stent technology for the treatment of diseased coronary arteries, major complications still affect the postoperative long-term outcome. The stent-induced flow disturbances, and especially the altered wall shear stress (WSS) profile at the strut level, play an important role in the pathophysiological mechanisms leading to stent thrombosis (ST) and in-stent restenosis (ISR). In this context, the analysis of the WSS topological skeleton is gaining more and more interest by extending the current understanding of the association between local hemodynamics and vascular diseases. This study aims to analyze the impact that a deployed coronary stent has on the WSS topological skeleton. Computational fluid dynamics (CFD) simulations were performed in three stented human coronary artery geometries reconstructed from clinical images. The selected cases presented stents with different designs (i.e., two contemporary drug-eluting stents and one bioresorbable scaffold) and included regions with stent malapposition or overlapping. A recently proposed Eulerian-based approach was applied to analyze the WSS topological skeleton features. The results highlighted that the presence of single or multiple stents within a coronary artery markedly impacts the WSS topological skeleton. In particular, repetitive patterns of WSS divergence were observed at the luminal surface, highlighting a WSS contraction action exerted proximal to the stent struts and a WSS expansion action distal to the stent struts. This WSS action pattern was independent from the stent design. In conclusion, these findings could contribute to a deeper understanding of the hemodynamics-driven processes underlying ST and ISR

New Therapeutic Options for the Treatment of Sickle Cell Disease.

Sickle cell disease (SCD; ORPHA232; OMIM # 603903) is a chronic and invalidating disorder distributed worldwide, with high morbidity and mortality. Given the disease complexity and the multiplicity of pathophysiological targets, development of new therapeutic options is critical, despite the positive effects of hydroxyurea (HU), for many years the only approved drug for SCD. New therapeutic strategies might be divided into (1) pathophysiology-related novel therapies and (2) innovations in curative therapeutic options such as hematopoietic stem cell transplantation and gene therapy. The pathophysiology related novel therapies are: a) Agents which reduce sickling or prevent sickle red cell dehydration; b) Agents targeting SCD vasculopathy and sickle cell-endothelial adhesive events; c) Anti-oxidant agents. This review highlights new therapeutic strategies in SCD and discusses future developments, research implications, and possible innovative clinical trials