16 research outputs found
Retrospective French nationwide survey of childhood aggressive vascular anomalies of bone, 1988-2009
<p>Abstract</p> <p>Objective</p> <p>To document the epidemiological, clinical, histological and radiological characteristics of aggressive vascular abnormalities of bone in children.</p> <p>Study design</p> <p>Correspondents of the French Society of Childhood Malignancies were asked to notify all cases of aggressive vascular abnormalities of bone diagnosed between January 1988 and September 2009.</p> <p>Results</p> <p>21 cases were identified; 62% of the patients were boys. No familial cases were observed, and the disease appeared to be sporadic. Mean age at diagnosis was 8.0 years [0.8-16.9 years]. Median follow-up was 3 years [0.3-17 years]. The main presenting signs were bone fracture (n = 4) and respiratory distress (n = 7), but more indolent onset was observed in 8 cases. Lung involvement, with lymphangiectasies and pleural effusion, was the most frequent form of extraosseous involvement (10/21). Bisphosphonates, alpha interferon and radiotherapy were used as potentially curative treatments. High-dose radiotherapy appeared to be effective on pleural effusion but caused major late sequelae, whereas antiangiogenic drugs like alpha interferon and zoledrenate have had a limited impact on the course of pulmonary complications. The impact of bisphosphonates and alpha interferon on bone lesions was also difficult to assess, owing to insufficient follow-up in most cases, but it was occasionally positive. Six deaths were observed and the overall 10-year mortality rate was about 30%. The prognosis depended mainly on pulmonary and spinal complications.</p> <p>Conclusion</p> <p>Aggressive vascular abnormalities of bone are extremely rare in childhood but are lifethreatening. The impact of anti-angiogenic drugs on pulmonary complications seems to be limited, but they may improve bone lesions.</p
Sur les rapports des instituteurs et de leurs chefs
Lepointe E.-L. Sur les rapports des instituteurs et de leurs chefs. In: La revue pédagogique, tome 59, Juillet-Décembre 1911. pp. 55-65
SynthÚse d'adamantylamines mono- et diphénylées antidépresseurs et bloquants potentiels de la recapture noradrénergique
Doctorat en Sciencesinfo:eu-repo/semantics/nonPublishe
A propos dâune circulaire controversĂ©e
Lepointe E.-L. A propos dâune circulaire controversĂ©e. In: Manuel gĂ©nĂ©ral de l'instruction primaire : journal hebdomadaire des instituteurs. 76e annĂ©e, tome 45, 1908. pp. 377-379
La littĂ©rature française Ă lâĂ©cole normale
Lepointe E. La littĂ©rature française Ă lâĂ©cole normale. In: Manuel gĂ©nĂ©ral de l'instruction primaire : journal hebdomadaire des instituteurs. 67e annĂ©e, tome 36, 1900. pp. 325-327
La « Culture » et les primaires
Lepointe E.-L. La « Culture » et les primaires. In: La revue pédagogique, tome 61, Juillet-Décembre 1912. pp. 101-112
La chanson des Nibelunge
Lepointe E. La chanson des Nibelunge. In: La revue pédagogique, tome 55, Juillet-Décembre 1909. pp. 170-181
Opinions de nos lecteurs
Lepointe E. Opinions de nos lecteurs. In: Manuel général de l'instruction primaire : journal hebdomadaire des instituteurs. 65e année, tome 34, 1898. p. 393